A5035398354- Landslides and related hazards
- Rock Mechanics and Modeling
- Structural Engineering and Vibration Analysis
- Geotechnical Engineering and Underground Structures
- Concrete and Cement Materials Research
- Coal Properties and Utilization
- Hydrology and Sediment Transport Processes
- Groundwater flow and contamination studies
- CAR-T cell therapy research
- Aeolian processes and effects
- Education, Safety, and Science Studies
- Elevator Systems and Control
- Advanced Computational Techniques and Applications
- Geotechnical Engineering and Analysis
- Infrastructure Maintenance and Monitoring
- Innovative concrete reinforcement materials
- Evacuation and Crowd Dynamics
- Geoscience and Mining Technology
- Winter Sports Injuries and Performance
- Civil and Geotechnical Engineering Research
- Advanced Data Processing Techniques
- Smart Materials for Construction
- Fluid Dynamics and Vibration Analysis
- Evaluation and Optimization Models
- Monoclonal and Polyclonal Antibodies Research
AbbVie (United States)
2024
PowerChina (China)
2020-2024
Hengshui University
2010-2011
Abstract Glucocorticoids are key components of the standard-of-care treatment regimens for B-cell malignancy. However, systemic glucocorticoid is associated with several adverse events. ABBV-319 a CD19-targeting antibody-drug conjugate engineered to reduce glucocorticoid-associated toxicities while possessing 3 distinct mechanisms action (MOA) increase therapeutic efficacy: (1) antibody-mediated delivery receptor modulator (GRM) payload activate apoptosis, (2) inhibition CD19 signaling, and...
The strain responses of asphalt pavement layer under vehicular loading are different from those falling weight deflectometer (FWD) loading, due to the discrepancies between two types loadings. This research aims evaluate and compare FWD Two full‐scale structures, namely, flexible semirigid pavement, were constructed instrumented with gauges. layers loadings measured analyzed. Except for field measurements, finite element (FE) models experimental pavements established simulate a wide range...
It has become a research hotspot to explore raw material substitutes of concrete. is important the mechanical properties self-compacting concrete (SCC) with slag powder (SP) and rubber particle (RP) replacing cement coarse aggregate, respectively. 12 kinds composite modified (CMSCC) specimens were prepared by using 10%, 20% 30% SP 30%, 40%, 50% 60% RP. The rheological properties, microstructure CMSCC investigated. Results indicate that workability, compressive strength, splitting tensile...
Abstract As China’s infrastructure continues to advance, tunnels will encounter increasingly complex geological conditions during construction. High geothermal heat seriously affects not only the normal construction of but also physical and mental health workers. Due existing cooling measures have poor effect high energy consumption, so ventilation system is neglected. This paper studies influence on temperature inside tunnel under different air supply volumes, distribution tunnel. The...
Traditionally, temperature control for massive concrete structures during the construction phase is based on experience instead of using advanced methods such as predictive method. In this paper, a method with hybrid data-based artificial neural network (ANN) model proposed. The main parameters numerical are identified data measured from site. Since limitation data, rich dataset generated by parameters. Finally, ANN predicting indicator developed. A case study in which real bridge anchorage...
Rockburst is a type of dynamic instability failure phenomenon and frequently brings huge losses to underground engineering projects such as mines tunnels. In order explore rockburst mechanisms predict rockbursts better, relying on the background Wulaofeng deep-buried highway tunnel, in situ stress measurement was performed using new wireless devices, mechanics tests surrounding rock samples taken from different burial depths were carried out. The mechanism explored microscopic perspective...
Flow around a round-ended caisson in the submerging process is investigated using k−ω SST turbulent model and volume of fluid (VOF) method present study. Six types vortex structures are identified, i.e. neck front cylinder near free surface, attached below end tip originating from end, spanwise on side U-shaped behind trailing wake. The influence bottom boundary vortexes analysed. physical generation mechanism vorticity surface discussed. Additionally, drag coefficient increases with Fr when...
Abstract Mudstone is a typical type of soft rocks. It stable and has high strength in its natural state. However, presence water the constituent minerals dissolve inter-grain bonds are weakened, which thereby greatly reduces mudstone. As one most prevailing geological formations southwestern China, understanding mechanical behaviour mudstone at different degrees disintegration great importance to practical engineering. This paper presents micro-mechanical analysis on using discrete element...
Water inrush and mud pose a serious threat to safe construction in underground engineering, but it is very difficult determine the distance of outburst prevention rock mass. Based on deep-buried tunnel this paper proposes method from water disaster between fault fracture zone. This combines numerical modeling backpropagation (BP) neural network. By means simulation, internal influence law pressure, lateral pressure coefficient, zone width, burial depth surrounding analyzed. The evolution...
. The relative elevation of the beginning and end Jianyuan Expressway exceed 1000m. In order to overcome impact large slope on traffic safety, a spiral tunnel was designed in middle expressway. length is 3970m radius 710~730m with its being up 2.08%. occurrence has great ventilation smoke during construction, but little research been done before. this paper, numerical simulation field test were used study effect diffusion characteristics pollutants. It found that as increased, wind speed CO...
Minimizing uncertainties is an important issue among the significant discussions pertaining to project design and planning. Usually, in subsurface projects arise from unknown ground conditions that may cause designer fail consider all potential issues prone occur during construction procedure. This paper presents a Bayesian framework predict before excavation. The state transition probability calculated by difference between simulation results observation data so model parameters gradually...
Abstract Bearing capacity of the composite beam is analysis with three nonlinear finite element methods in thesis, which Hognostand’s uniaxial compression equation and BKIN model was applied to represent constitutive relationship concrete steel consideration nonlinearity yield strengthening characteristics respectively. The interface slip between reasonably taken into account two methods. Those are compared according result, character those discussed verified experimental result.