A5004616175- Cystic Fibrosis Research Advances
- Pneumonia and Respiratory Infections
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neonatal Respiratory Health Research
- Respiratory viral infections research
Michigan State University
2021-2022
Idiopathic pulmonary fibrosis (IPF) is a pathological condition of unknown etiology that results from injury to the lung and an ensuing fibrotic response leads thickening alveolar walls obliteration space. The pathogenesis not clear, there are currently no effective therapies for IPF. Small airway disease mucus accumulation prominent features in IPF lungs, similar cystic disease.
Cystic fibrosis (CF) is caused by genetic mutations of the CF transmembrane conductance regulator (CFTR), leading to disrupted transport Cl- and bicarbonate lung disease featuring bacterial colonization chronic infection in conducting airways. pigs engineered mutating CFTR develop that mimics human CF, are well-suited for investigating therapeutics. Clinical data suggest small airways play a key role early pathogenesis disease, but few preclinical studies have focused on Efficient targeted...
Abstract Idiopathic Pulmonary Fibrosis (IPF) is a pathological condition of unknown etiology which results from injury to the lung and an ensuing fibrotic response that leads thickening alveolar walls obliteration space. The pathogenesis not clear there are currently no effective therapies for IPF. Small airway disease mucus accumulation prominent features in IPF lungs, similar Cystic (CF) disease. ATP12A gene encodes alpha-subunit non-gastric H + , K -ATPase, functions acidify surface fluid...