A5101568584- Viral-associated cancers and disorders
- Immune Cell Function and Interaction
- Lymphoma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Traditional Chinese Medicine Analysis
- Genetic factors in colorectal cancer
- Cancer Mechanisms and Therapy
- Cell death mechanisms and regulation
- Ectopic Pregnancy Diagnosis and Management
- Clusterin in disease pathology
- Colorectal Cancer Treatments and Studies
- Ferroptosis and cancer prognosis
- Gastric Cancer Management and Outcomes
- Silymarin and Mushroom Poisoning
- Cancer Cells and Metastasis
- Synthesis and bioactivity of alkaloids
- Drug Transport and Resistance Mechanisms
- Effects of Radiation Exposure
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Gestational Trophoblastic Disease Studies
- Ion channel regulation and function
- Hepatocellular Carcinoma Treatment and Prognosis
- Biological and pharmacological studies of plants
Qilu University of Technology
2024
Shandong Academy of Sciences
2024
Peking University
2022-2024
Peking University International Hospital
2022-2024
Hebei Medical University
2019-2024
Third Hospital of Hebei Medical University
2019-2024
Brigham and Women's Hospital
2015-2023
Harvard University
2015-2023
Pingjin Hospital
2020
Guangdong Academy of Medical Sciences
2020
Abstract The 2023 update of the Chinese Society Clinical Oncology (CSCO) Guidelines for Gastric Cancer focuses on standardizing cancer diagnosis and treatment in China, reflecting latest advancements evidence‐based medicine, healthcare resource availability, precision medicine. These updates address differences epidemiological characteristics, clinicopathological features, tumor biology, patterns, drug selections between Eastern Western gastric patients. Key revisions include a structured...
Epstein-Barr virus (EBV) infection of human primary resting B lymphocytes (RBLs) leads to the establishment lymphoblastoid cell lines (LCLs) that can grow indefinitely
Significance EBV infection causes African Burkitt's lymphoma; Hodgkin's disease; lymphomas in immune suppressed people, including HIV infected people; nasopharyngeal carcinoma; and ∼10% of gastric carcinomas. We recently found super-enhancer (ESE) to be critical for lymphoblastoid cell (LCL) growth survival. now identified an ESE constituent, enhancer RNA (eRNA), that is important function. These eRNAs were activated by viral transactivator, nuclear antigen 2 (EBNA2). MYC oncogene able...
Abstract X‐linked lymphoproliferative disease is characterized by immune dysregulation and uncontrolled lymphoproliferation on exposure to Epstein–Barr virus (EBV). This has been attributed mutations in the SAP gene (also denominated as SH2D1A or DSHP ). To delineate role of pathophysiology disease, a strain sap ‐deficient mice generated deleting exon 2 gene. After infection with murine gammaherpesvirus‐68, which homologous EBV, mutant exhibit more vigorous CD8 + T cell proliferation...
Abstract Epstein-Barr virus (EBV) immortalization of resting B lymphocytes (RBLs) to lymphoblastoid cell lines (LCLs) models human DNA tumor oncogenesis. RBL and LCL chromatin interaction maps are compared identify the spatial temporal genome architectural changes during EBV transformation. induces global reorganization where contact domains frequently merge or subdivide Repressed compartments in RBLs switch active A LCLs. LCLs gain 40% new domain boundaries. Newly gained boundaries have...
To explore the proteins regulated by cyclooxygenase-2 (COX-2) in gastric cancer, expression plasmid of COX-2siRNA was constructed and transfected into cancer cell line SGC7901. Then, two-dimensional electrophoresis PDQuest software analysis were applied to discover differentially expressed proteins. The differential protein spots analyzed matrix-assisted laser desorption/ionization time flight mass spectrometry. Fourteen between two lines identified. 15-Hydroxyprostaglandin dehydrogenase...
Ras homolog family member C (RHOC) is important during the progression of several types cancer, including prostate, breast and hepatocellular carcinoma. However, function RHOC in cholangiocellular carcinoma (CCC), a highly recurrent metastatic with poor prognosis, remains unclear. The aim present study was to investigate involvement CCC tumor progression. expression levels were examined tissues cells, adjacent nontumorous bile duct tissues. effects molecular mechanisms on cell migration...
Secreted clusterin (sCLU) has been shown to be overexpressed in metastatic hepatocellular carcinoma (HCC) tissue, and its overexpression HCC cells increases cell migration the formation of liver tumor nodules vivo. In this study, we tested hypothesis that sCLU plays a role invasiveness human may associated with spread. HCCLM3, line, was transiently transfected an antisense oligonucleotide (ASO) against (OGX-011). HepG2 were pc.DNA3.1-sCLU plasmid overexpress sCLU, subsequently evaluated for...
Epstein-Barr Virus (EBV) Nuclear Antigen 1 (EBNA1)-mediated origin of plasmid replication (oriP) DNA episome maintenance is essential for EBV-mediated tumorigenesis. We have now found that EBNA1 binds to Ribosome Protein L4 (RPL4). RPL4 shRNA knockdown decreased activation an oriP luciferase reporter, binding in lymphoblastoid cell lines, and EBV genome number per line. infection increased expression redistributed nuclei. Nucleolin (NCL) were a scaffold EBNA1-induced complex. The N terminus...
Pancreatic cancer is one of the leading causes cancer-related mortality in both developed and developing countries. The incidence pancreatic China accounts for about a quater global incidence, epidemiological characteristics therapeutic strategies differ due to social, economic, cultural, environmental, public health factors. Non-domestic guidelines do not reflect clinicopathologic treatment patterns Chinese patients. Thus, 2018, Society Clinical Oncology (CSCO) organized panel senior...
ABSTRACT Epstein-Barr virus nuclear antigen (EBNA) leader protein (EBNALP) is one of the first viral genes expressed upon B-cell infection. EBNALP essential for EBV-mediated immortalization. thought to function primarily by coactivating EBNA2-mediated transcription. Chromatin immune precipitation followed deep sequencing (ChIP-seq) studies highlight that frequently cooccupies DNA sites with host cell transcription factors (TFs), in particular, EP300, implicating a broader role regulation. In...
Treatment options for radiation-induced intestinal injury (RIII) are limited. Crocetin has been demonstrated to exert antioxidant, antiapoptotic, and anti-inflammatory effects on various diseases. Here, we investigate the of crocetin RIII in vitro. Materials Method. IEC-6 cells exposed 10 Gy radiation were treated with different doses (0, 0.1, 1, 10, 100 μM), cell viability was assessed by CCK-8. The levels superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx),...
Ras homologous (Rho) family GTPases play a pivotal role in the regulation of numerous cellular functions associated with malignant transformation and metastasis. To evaluate these colorectal cancer, mRNA expression levels matched sets tumor non-tumor tissues from surgical specimens were analyzed. The relationship between to clinicopathological features was also assessed.A total 68 patients carcinoma recruited RhoA RhoC transcripts paratumoral normal characterized by quantitative real-time...
The topic of radiation always provokes public debate, and the uses for therapeutic other purposes have been associated with some anxiety. Salvia miltiorrhiza Bunge has widely used treatment various diseases including cerebrovascular diseases, coronary artery myocardial infarction. Salvianolic acid A (SAA) d (+)-(3,4-dihydroxyphenyl) lactic is principal effective, watersoluble constituent Bunge. In our present study, radiation-induced DNA damage apoptosis in human intestinal epithelial cells...
Silymarin, the main flavonoid constituent element extracted from Silybum marianum possessing antioxidant activity, is already known to be able block NF-κB activation process and result in cell apoptosis, implicating silymarin's potential control cancer growth.In this study, based upon above assumption, silymarin was administered a highly metastatic lung line Anip973 test role proliferation.Silymarin had significant inhibitory effects on proliferation of cells dose-dependent time-response...
There is an increasing use of herbal medicines worldwide, and the extracts from root Salvia miltiorrhiza are widely used in treatment angina stroke. In this study, we investigated mechanism for intestinal absorption tanshinone IIB (TSB), a major constituent S. miltiorrhiza. The oral bioavailability TSB was about 3% rats with less proportional increase its maximum plasma concentration (Cmax) area under concentration–time curve (AUC) dosage. time to Cmax (Tmax) prolonged at higher single pass...