A5032705127- Liver Disease Diagnosis and Treatment
- Infant Nutrition and Health
- Ferroptosis and cancer prognosis
- Neonatal Respiratory Health Research
- MicroRNA in disease regulation
- Health disparities and outcomes
- Cancer, Lipids, and Metabolism
- Glioma Diagnosis and Treatment
- Intergenerational Family Dynamics and Caregiving
- Cancer-related molecular mechanisms research
- Cancer Risks and Factors
- Aging and Gerontology Research
- Thermal Regulation in Medicine
- Diet, Metabolism, and Disease
- Advanced Glycation End Products research
- Circular RNAs in diseases
- Biofield Effects and Biophysics
- Cancer, Stress, Anesthesia, and Immune Response
- Alcohol Consumption and Health Effects
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Botulinum Toxin and Related Neurological Disorders
- Epigenetics and DNA Methylation
- Protein Kinase Regulation and GTPase Signaling
- Cerebral Palsy and Movement Disorders
- Extracellular vesicles in disease
Hubei Provincial Hospital of Traditional Chinese Medicine
2020-2025
Second Military Medical University
2025
Shanghai Sixth People's Hospital
2021-2024
Shanghai Jiao Tong University
2024
Third Affiliated Hospital of Sun Yat-sen University
2022-2024
Sun Yat-sen University
2022-2024
Hubei University of Chinese Medicine
2021-2023
Guangdong Academy of Medical Sciences
2018-2022
Guangdong Provincial People's Hospital
2020-2022
Key Laboratory of Guangdong Province
2022
Abstract Acetaminophen (APAP) stands as the predominant contributor to drug-induced liver injury (DILI), and limited options are available. β-Arrestin1 (ARRB1) is involved in numerous diseases. However, role of ARRB1 APAP-induced remained uncertain. Wild-type (WT) knockout (KO) mice were injected with APAP sacrificed at indicated times. The histological changes, inflammation, endoplasmic reticulum (ER) stress, apoptosis then evaluated. Hepatic cell lines AML-12 primary hepatocytes used for...
With the world's population increasing in age, there has been a significant rise prevalence of cognitive impairment and dementia among individuals. This study aims to investigate association between grandparenting function middle-aged older Chinese using data from 2011 2018 China Health Retirement Longitudinal Study (CHARLS). Additionally, seeks explore potential mediating effect intergenerational support children on this relationship, CHARLS database.
Abstract Treatment options for necrotizing enterocolitis (NEC) remain inadequate. Here we examined if and how prolyl hydroxylase 2 (PHD2) silencing enhances the paracrine effects of bone-marrow-derived mesenchymal stem cells (BM-MSCs) on NEC. In this study, BM-MSCs were transduced with lentiviruses containing GFP (GFP-MSC) or shPHD2-GFP constructs (PHDMSC), followed by intraperitoneal injection PHDMSC-conditioned medium (PHDMSC-CM) GFP-MSC-conditioned (MSC-CM) into a rat pup model Our...
Glioblastoma multiforme (GBM) is one of the most malignant tumors in brain with high morbidity and mortality. Mitophagy plays a significant role carcinogenesis, metastasis, invasion. In our study, we aim to construct mitophagy-related risk model predict prognosis GBM.RNA-seq data combined clinical information were downloaded from TCGA. The 4-gene nomograph was then constructed validated external cohort. Evaluation immune infiltration, functional enrichment tumor microenvironment (TME)...
Content and aims: Ginsenoside RG1 (RG1) is thought to enhance proliferation differentiation of stem cell, however, its role on paracrine efficacy cell remains unclear. Here we examined if how enhances the effects bone marrow-derived mesenchymal cells (BM-MSCs) radiation induced intestinal injury (RIII).Irradiated rats randomly received intraperitoneal injection conditioned medium (CM) derived from non-activated BM-MSCs (MSC-CM) or pre-activated by RG-1 (RG1-MSC-CM). Intestinal samples were...
Treatment options for radiation-induced intestinal injury (RIII) are limited. Crocetin has been demonstrated to exert antioxidant, antiapoptotic, and anti-inflammatory effects on various diseases. Here, we investigate the of crocetin RIII in vitro. Materials Method. IEC-6 cells exposed 10 Gy radiation were treated with different doses (0, 0.1, 1, 10, 100 μM), cell viability was assessed by CCK-8. The levels superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx),...
Emerging evidence suggested that mitophagy may play an important role in the progression of hepatocellular carcinoma (HCC), whereas association between mitophagy-related genes and HCC patients’ prognosis remains unknown. In this study, we aimed to investigate potential prognostic values (MRGs) on patients at genetic level. According median immunoscore, categorized from TCGA cohort into two immune score groups, while 39 differential expression MRGs were identified. By using univariate...
Abstract Bioactive constituents from Rhodiola rosea L. (RRL) exhibit multiple pharmacological effects on diverse diseases. However, whether they are suitable for the treatment of radiation‐induced intestinal injury (RIII) remains unclear. This study aims to investigate their roles and mechanisms in RIII rat model. The radioprotective four bioactive RRL (salidroside, herbacetin, rosavin arbutin) were evaluated by cell viability irradiated IEC‐6 cells. Intestinal tissues collected histological...
To review the conversion therapy for initially unresectable hepatocellular carcinoma (HCC) patients and suitable timing subsequent salvage surgery.A PubMed search was undertaken from 1987 to 2017 identify articles using keywords including "unresectable" "hepatocellular carcinoma", "hepatectomy", "conversion therapy", "resection", "salvage surgery" "downstaging". Additional studies were investigated through a manual of references articles. The exclusion criteria duplicates, case reports,...
A total of 37 cases thyroid tumors with pathological features suggestive DICER1 gene mutation were selected to detect the and BRAF using Sanger sequencing. 10 patients (27.0%) exhibited all whom female an age [
Glioma is a primary, malignant, and aggressive brain tumor in adults. To develop new therapeutic strategies for glioma, we must determine its underlying mechanisms. In the present study, aimed to investigate potential role of miR-1272-ADAM9-CDCP1 signaling progression glioma. We found that ectopic expression miR-1272 produced significant inhibitory effects on cell proliferation migration was associated with cycle G0/G1 arrest A172 SHG44 glioma cells. Using luciferase reporter assay,...
Abstract Background Excessive alcohol intake with hepatitis B virus (HBV) infection accelerates chronic liver disease progression and patients HBV are more susceptible to alcohol-induced disease. Hepatitis X protein (HBx) plays a crucial role in pathogenesis, while its specific alcoholic (ALD) has not yet been elucidated. Here, we studied the of HBx on development ALD. Methods HBx-transgenic (HBx-Tg) mice their wild-type littermates were exposed plus binge feeding. Primary hepatocytes, cell...
The risk of fall seriously affects the health and quality life middle-aged elderly people, especially injury disability caused by which imposes a huge burden on family social medical care. Baduanjin exercise may be an effective intervention to enhance muscle strength stability lower limbs, improve balance ability gait reduce incidence falls, life, promote people. aim this study is summarize evidence systematically review efficacy safety function in people.We conducted systematic search...
Colon cancer (CC) is one of the most common cancers with high morbidity globally. Ubiquitination involved in characterization multiple biological processes, and some ubiquitinated enzymes are associated prognosis CC. However, prognostic model ubiquitination-related genes (URGs) for CC unavailable.Gene expression data, somatic mutations, transcriptome profiles, microsatellite instability status (MSI) status, clinical information were obtained from The Cancer Genome Atlas (TCGA) dataset. Seven...
Aim: It is to be elucidated the risk-predictive role of differentially expressed fatty acid metabolism related genes (DE-FRGs) in dilated cardiomyopathy (DCM) and myocardial infarction. Materials & methods: Four gene enrichment analyses defined DE-FRGs' biological functions pathways. Three strategies were applied identify risk biomarkers construct a nomogram. The 4-DE-FRG correlation with immune cell infiltration, drugs, ceRNA was explored. Results: DE-FRGs enriched lipid metabolism. A...
Objective: To investigate the clinical, radiological, histological and molecular features differential diagnosis of fibrocartilaginous mesenchymoma (FM). Methods: Four cases FM diagnosed in Department Pathology, Sixth People's Hospital Affiliated to Shanghai Jiaotong University School Medicine from 2020 2022 were analyzed. Related literature was also reviewed. Results: Case 1 a 10-year-old girl with bone destruction sacrum L5 articular processes revealed by CT scan. 2 7-year-old an...