A5103044387- Gastroesophageal reflux and treatments
- Ferroptosis and cancer prognosis
- Helicobacter pylori-related gastroenterology studies
- Liver Disease Diagnosis and Treatment
- Pneumonia and Respiratory Infections
- Cancer, Lipids, and Metabolism
- Inflammatory Bowel Disease
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- Eating Disorders and Behaviors
- Glioma Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Infant Nutrition and Health
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Obesity, Physical Activity, Diet
- Epigenetics and DNA Methylation
- Obesity and Health Practices
- Inflammasome and immune disorders
- Cancer Immunotherapy and Biomarkers
- Pharmacological Effects of Medicinal Plants
- Colorectal Cancer Treatments and Studies
- Phytoestrogen effects and research
- Heme Oxygenase-1 and Carbon Monoxide
- Respiratory Support and Mechanisms
South China University of Technology
2021-2025
Guangdong Academy of Medical Sciences
2020-2025
Southern Medical University
2023-2025
Guangdong Provincial People's Hospital
2020-2025
University of California, Los Angeles
2024
Shantou University
2024
Shantou University Medical College
2024
VA Sepulveda Ambulatory Care Center
2024
Fujian University of Traditional Chinese Medicine
2020-2023
Bioscience (China)
2022
Abstract Background In the post-pandemic era, a wide range of COVID-19 sequelae is growing health concern. However, risks digestive diseases in long COVID have not been comprehensively understood. To investigate long-term risk among patients. Methods this large-scale retrospective cohort study with up to 2.6 years follow-up (median follow-up: 0.7 years), group ( n = 112,311), contemporary comparison 359,671) and historical 370,979) predated outbreak were built using UK Biobank database. Each...
Background: Emerging evidence has proven that ferroptosis plays an important role in the development of acute myeloid leukemia (AML), whereas exact ferroptosis-associated genes AML patients' prognosis remained unclear. Materials and Methods: Gene expression profiles corresponding clinical information cases were obtained from TCGA (TCGA-LAML), GEO (GSE71014), TARGET databases (TARGET-AML). Patients cohort well-grouped into two clusters based on ferroptosis-related genes, differentially...
Observational studies have indicated associations between inflammatory bowel disease (IBD) and neurodegenerative diseases, including Parkinson's (PD).To evaluate the causal of IBD with PD other selected disorders using updated data.Bidirectional two-sample Mendelian randomization genome-wide association summary statistics PD.We found a lack evidence for on (odds ratio [OR], 1.014; 95% confidence interval [CI], 0.967-1.063; P = 0.573). Reverse analysis also no effect (OR, 0.978; CI,...
Rationale:The therapeutic benefits of bilirubin in the treatment ulcerative colitis (UC) are considerable, whereas underlying mechanism on UC remains unclear unexplored.In addition, weak hydrophilicity and toxicity have limited its translational applications.Methods: We developed a colon dual-targeting nanoparticle, for orally delivering through hydrogel encapsulation hyaluronic acid (HA)-modified poly (lactic-co-glycolic acid) (PLGA) nanoparticles (HA-PLGABilirubin).Confocal microscopy vivo...
Abstract Background Emerging evidence suggests that Rho GTPases play a crucial role in tumorigenesis and metastasis, but their involvement the tumor microenvironment (TME) prognosis of hepatocellular carcinoma (HCC) is not well understood. Methods We aim to develop prediction system called GTPases-related gene score (RGPRG score) using GTPase signaling genes further bioinformatic analyses. Results Our work found HCC patients with high RGPRG had significantly worse survival increased...
Mitophagy is a conserved cellular process that plays vital role in maintaining homeostasis by selectively removing dysfunctional mitochondria. Notwithstanding growing evidence suggests mitophagy implicated pancreatic tumorigenesis, the effect of mitophagy-related genes on cancer (PC) prognosis and therapeutic response remains largely unknown. In this study, we sought to construct gene signature assessed its ability predict survival, immune activity, mutation status, chemotherapy PC patients....
Clear cell renal carcinoma (ccRCC), the most prevalent cancer subtype, is frequently associated with poor prognosis. RHO-GTPase signaling genes have been implicated in tumor aggressiveness and unfavorable survival, but their potential risk stratification therapeutic guidance for ccRCC patients remains unexplored. Univariate regression identified prognostically relevant genes, followed by consensus clustering subtype classification. LASSO selected key to construct a six-gene model. The model...
Adverse effects of proton pump inhibitors (PPIs) have raised wide concerns. The association PPIs with influenza is unexplored, while that pneumonia or COVID-19 remains controversial. Our study aims to evaluate whether PPI use increases the risks these respiratory infections. current included 160,923 eligible participants at baseline who completed questionnaires on medication use, which histamine-2 receptor antagonist (H2RA), from UK Biobank. Cox proportional hazards regression and propensity...
Emerging observational studies have indicated the association between autism spectrum disorder (ASD) and IBD, including Crohn's disease (CD) ulcerative colitis (UC), whereas causality remains unknown. Summary-level data from large-scale genome-wide (GWAS) of IBD ASD were retrieved. Mendelian randomisation analyses performed with a series sensitivity tests. Genetic predisposition to was not associated risk (odds ratio [OR] = 0.99, 95% confidence interval [CI 0.91-1.06, p 0.70; OR [95% CI]:...
Glioblastoma multiforme (GBM) is one of the most malignant tumors in brain with high morbidity and mortality. Mitophagy plays a significant role carcinogenesis, metastasis, invasion. In our study, we aim to construct mitophagy-related risk model predict prognosis GBM.RNA-seq data combined clinical information were downloaded from TCGA. The 4-gene nomograph was then constructed validated external cohort. Evaluation immune infiltration, functional enrichment tumor microenvironment (TME)...
Published observational studies have revealed the connection between neurodegenerative disorders and inflammatory bowel disease (IBD), whereas causal association remains largely unclear. Our study aims to assess causality identify shared genetic architecture IBD. Two-sample Mendelian randomization analyses were performed IBD (amyotrophic lateral sclerosis [ALS], Alzheimer's [AD], Parkinson's [PD], multiple [MS]). Shared loci, functional interpretation, transcriptomic profiles further...
Treatment options for radiation-induced intestinal injury (RIII) are limited. Crocetin has been demonstrated to exert antioxidant, antiapoptotic, and anti-inflammatory effects on various diseases. Here, we investigate the of crocetin RIII in vitro. Materials Method. IEC-6 cells exposed 10 Gy radiation were treated with different doses (0, 0.1, 1, 10, 100 μM), cell viability was assessed by CCK-8. The levels superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx),...
Energy metabolism plays a crucial role in the improvement of heart dysfunction as well development failure (HF). The current study is designed to identify energy metabolism-related diagnostic biomarkers for predicting risk HF due myocardial infarction. Transcriptome sequencing data patients and non-heart (NF) people (GSE66360 GSE59867) were obtained from gene expression omnibus (GEO) database. differentially expressed genes (DEGs) screened between NF samples. subtyping consistency analysis...
Emerging evidence suggested that mitophagy may play an important role in the progression of hepatocellular carcinoma (HCC), whereas association between mitophagy-related genes and HCC patients’ prognosis remains unknown. In this study, we aimed to investigate potential prognostic values (MRGs) on patients at genetic level. According median immunoscore, categorized from TCGA cohort into two immune score groups, while 39 differential expression MRGs were identified. By using univariate...
Esophageal adenocarcinoma (EAC) is a highly malignant type of digestive tract cancers with poor prognosis despite therapeutic advances. Pyroptosis an inflammatory form programmed cell death, whereas the role pyroptosis in EAC remains largely unknown. Herein, we identified pyroptosis-related five-gene signature that was significantly correlated survival patients The Cancer Genome Atlas (TCGA) cohort and independent validation dataset. In addition, nomogram based on constructed novel...
Introduction Crohn’s disease is characterized of dysregulated inflammatory and immune reactions. The role the NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome in remains largely unknown. Methods microarray-based transcriptomic data corresponding clinical information GSE100833 GSE16879 were obtained from Gene Expression Omnibus (GEO) database. Identification NLRP3 inflammasome-related genes construction LASSO regression model. Immune landscape analysis was evaluated...
Inflammatory bowel diseases (IBD) are chronic inflammatory disorders affecting the digestive tract, including ulcerative colitis and Crohn’s disease. Ruscogenin, a prominent steroidal sapogenin present in radix ophiopogon japonicus, has shown protective effect on attenuating response associated with diseases, but efficacy of ruscogenin IBD remains unclear. The aim this study is to explore intestinal barrier dysfunction responses as well underlying mechanism colitis. A dextran sulfate sodium...