A5044535902- RNA modifications and cancer
- Galectins and Cancer Biology
- Cancer Research and Treatments
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Ubiquitin and proteasome pathways
- Glycosylation and Glycoproteins Research
- Autophagy in Disease and Therapy
- Esophageal and GI Pathology
- Medical Imaging and Pathology Studies
- Cancer-related gene regulation
- Monoclonal and Polyclonal Antibodies Research
- Hippo pathway signaling and YAP/TAZ
- Occupational and environmental lung diseases
- Head and Neck Surgical Oncology
- Hereditary Neurological Disorders
- HER2/EGFR in Cancer Research
- Tracheal and airway disorders
- Cancer-related Molecular Pathways
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Lipid metabolism and disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Function and Risk Factors
- Reconstructive Surgery and Microvascular Techniques
Shaanxi University of Chinese Medicine
2025
Second Military Medical University
2025
Sahlgrenska University Hospital
2024
Region Västra Götaland
2024
University of Gothenburg
2017-2024
Affiliated Hospital of North Sichuan Medical College
2010-2024
The University of Texas MD Anderson Cancer Center
2019
Quest Diagnostics (United States)
2015
VA Greater Los Angeles Healthcare System
2014
Memorial Sloan Kettering Cancer Center
2010-2014
Recent single-arm studies involving neoadjuvant camrelizumab, a PD-1 inhibitor, plus chemotherapy for resectable locally advanced esophageal squamous cell carcinoma (LA-ESCC) have shown promising results. This multicenter, randomized, open-label phase 3 trial aimed to further assess the efficacy and safety of camrelizumab followed by adjuvant compared alone. A total 391 patients with thoracic LA-ESCC (T1b-3N1-3M0 or T3N0M0) were stratified clinical stage (I/II, III IVA) randomized in 1:1:1...
LBA244 Background: Neoadjuvant chemotherapy or chemoradiotherapy followed by surgery is the standard of care for resectable locally advanced esophageal squamous cell carcinoma (LA-ESCC). However, recurrence post-surgery remains a concern. Recent single-arm studies with neoadjuvant camrelizumab plus showed promising results. This multicenter, randomized, open-label, phase III study aims to evaluate role adjuvant camrelizumab, versus alone LA-ESCC. Methods: Patients thoracic LA-ESCC...
Understanding tumor-induced angiogenesis is a challenging problem with important consequences for the diagnosis and treatment of cancer. In this study, we define novel function epithelial membrane protein-2 (EMP2) in control angiogenesis. EMP2 functions as an oncogene endometrial cancer, its expression has been linked to decreased survival. Using cancer xenografts, modulation resulted profound changes tumor microvasculature. Under hypoxic conditions, upregulation promoted vascular...
Despite significant advances in biology and medicine, the incidence mortality due to breast cancer worldwide is still unacceptably high. Thus, there an urgent need discover new molecular targets. In this article, we show evidence for a novel target human cancer, tetraspan protein epithelial membrane protein-2 (EMP2). Using tissue tumor arrays, expression of EMP2 was measured found be minimal normal mammary tissue, but it upregulated 63% invasive tumors 73% triple-negative tested. To test...
Endometrial cancer is the most common gynecologic malignancy diagnosed among women in developed countries. One recent biomarker strongly associated with disease progression and survival epithelial membrane protein-2 (EMP2), a tetraspan protein known to associate modify surface expression of certain integrin isoforms. In this study, we show using xenograft model system that EMP2 necessary for efficient endometrial tumor formation, have started characterize mechanism by which contributes...
Abstract Purpose: The tetraspan protein epithelial membrane protein-2 (EMP2) has been shown to regulate the surface display and signaling from select integrin pairs, it was recently identified as a prognostic biomarker in human endometrial cancer. In this study, we assessed role of EMP2 ovarian Experimental Design: We examined expression within population women with cancer using tissue microarray assay technology. evaluated efficacy EMP2-directed antibody therapy fully recombinant bivalent...
Abstract Purpose: Endometrial cancer is the most common gynecologic malignancy. One promising biomarker epithelial membrane protein 2 (EMP2), and its expression an independent prognostic indicator for tumors with poor clinical outcome expression. The present study assesses suitability of EMP2 as a therapeutic target. Experimental Design: Human monovalent anti-EMP2 antibody fragments were isolated from human phage display library engineered bivalent (diabodies) specificity avidity to both...
The aim of this study was to examine the effects esophageal cancer-related gene 4 (ECRG4) expression levels on chemotherapeutic sensitivity gastric cancer cells. A SGC-7901 cell system with tetracycline-inducible ECRG4 (SGC-7901/ECRG4) successfully established. mRNA and protein were detected using quantitative reverse transcription polymerase chain reaction Western blotting, respectively. Chemosensitivity 5-fluorouracil (5-FU) examined by proliferation assay apoptosis assay. significantly...
As imaging of the cell surface tetraspan protein epithelial membrane protein-2 (EMP2) expression in malignant tumors may provide important prognostic and predictive diagnostic information, goal this study is to determine if antibody fragments EMP2 be useful for positive tumors. The normal tissue distribution was evaluated by immunohistochemistry found discretely expressed both mouse human tissues. To detect tumors, a recombinant anti-EMP2 minibody (scFv-hinge-CH3 dimer; 80 kDa) designed...
In this study, we investigated whether COL4A3 mRNA expression levels were associated with clinical outcomes after treatment a combination of gemcitabine (Gem)/cis-diamminedichloroplatinum(II) (CDDP) regimen for patients advanced stage non-small cell lung cancer (NSCLC). Response and survival correlated the level in 58 (stage IIIb or IV) NSCLC treated as part multicenter randomized trial Gem 1,250 mg/m(2) on days 1 8 plus CDDP 100 day every 3 weeks. was isolated from paraffin-embedded...
To compare the differences in dietary status and knowledge of esophageal cancer (EC) between residents high- low-incidence areas. We investigated conditions EC among low-EC incidence areas (Yanting Qingzhen counties). Residents Yanting consumed more pickled vegetables, salted meat barbecued food (P < 0.05). Analysis past ten-year trend fresh vegetables/fruits, beans, sauerkraut, hot food, had gradually increased, was less than that County. However, gradual increasing consumption meat, spicy...
The current treatment strategies for borderline resectable esophageal squamous cell carcinoma remain controversial. This study aimed to evaluate the efficacy and safety of programmed death 1 inhibitors combined with chemotherapy, followed by conversion surgery, carcinoma. Patients treated induction immunochemotherapy from January 1, 2020 July 2023 at our hospital were retrospectively analyzed. primary outcome was R0 resection rate. Secondary outcomes included progression-free survival (PFS),...
To develop an assay to quantify serum immunoglobulin (IgG, IgM, IgA) levels using dried blood spots (DBS) obtained on collection cards be used as a tool for targeted screening hypogammaglobulinemia. DBS samples, along with simultaneous were collected from 107 healthy individuals (11 months 57 years of age). After eluting proteins DBS, IgG, and IgA quantified by enzyme-linked immunosorbent (ELISA). The Ig-DBS was validated through calibration curve performance, intra- inter-assay precision,...
Variations in the course and distribution of common palmar digital nerves arteries are rare. A classic defined as concomitant. During routine dissection classes to undergraduate medical students we observed formation each nerve divided into 2 or 3 branches formed a ring enclosing corresponding artery. Knowledge anatomical variations is crucial for safe successful hand surgery.
Minimally invasive McKeown esophagectomy (MIE McKeown) with cervical anastomosis is a widely used approach for the treatment of esophageal cancer (EC). Anastomotic leak one most serious complications following esophagectomy. This study aimed to summarize procedure and assess clinical outcomes our modified layered hand-sewn end-to-side during MIE McKeown.We retrospectively reviewed data 508 consecutive EC patients who underwent using between June 2016 2020.The incidence anastomotic leakage in...
Abstract Background Heart failure remains a significant health burden, characterized by disabling symptoms and mortality rates comparable to cancer. Mineralocorticoid antagonists (MRAs), pivotal in treating heart with reduced ejection fraction (HFrEF), are underutilized due concerns of hyperkalemia. Sodium Zirconium Cyclosilicate (SZC) enables optimized MRA therapy reducing However, prospective studies on the efficacy safety SZC patients HFrEF high hyperkalemia risk lacking, particularly...
Abstract Background There is a paucity of data on the long-term outcomes heart failure (HF) patients in China. We aimed to investigate incidence cardiovascular (CV) death or rehospitalization due worsening HF (WHF) and other among different subtypes with chronic Methods Data from China National registry (CN-HF) during period 1 February 2013–31 October 2015 were analyzed. Patients categorized into three groups based their left ventricular ejection fraction (LVEF): reduced (HFrEF, LVEF≤40%),...
The incidence and mortality rates of early pulmonary embolism (PE) after thoracic surgery are high. Thrombolytic therapy is the basic treatment PE. aim this study to explore safety efficacy thrombolytic for patients with postoperative