Many countries and regions have experienced male fertility problems due to various influencing factors, especially in less developed countries. Unlike female infertility, infertility receives insufficient attention. Understanding the changing patterns of world, different is crucial for assessing global reproductive health.We obtained data on prevalence, years life lived with disability (YLD), age-standardized rates prevalence (ASPR) YLD rate (ASYR) from Global Burden Disease Study 2019. We...

Melatonin is a critical regulator of biological rhythms across organisms, transducing light signals into neuroendocrine that facilitate reproductive regulation in response to environmental cues. However, the precise mechanisms through which melatonin regulates reproduction fish require further investigation. In this study, we employed molecular and organizational techniques examine expression patterns its five receptor subtypes (LcMTNR1A1, LcMTNR1A2, LcMTNR1B1, LcMTNR1B2, LcMTNR1C) various...

Background In recent times, reports have emerged suggesting that a variety of autoimmune disorders may arise after the coronavirus disease 2019 (COVID-19) vaccination. However, causality and underlying mechanisms remain unclear. Methods We collected summary statistics COVID-19 vaccination 31 diseases from genome-wide association studies (GWAS) as exposure outcome, respectively. Random-effects inverse variance weighting (IVW), MR Egger, weighted median, simple mode, mode were used analytical...

Women with obesity usually need larger doses of FSH for ovarian stimulation, resulting in poor outcomes; however, the mechanism is still unclear. To investigate molecular regulation receptor (FSHR) expression associated obesity. Case-control study to improve vitro fertilization (IVF) outcomes. (82) and women who were overweight (457) undergoing IVF 1790 age-matched controls normal weight from our reproductive medicine center. FSHR was decreased parallel body mass index (BMI), whereas...

Perioperative neurocognitive disorders have been widely recognized as common adverse events after surgical intervention. Aging is one of the most important independent risk factors for worsened cognitive outcome, and this deterioration linked to exacerbated microglia-mediated neuroinflammation in aged brain. Under pathological stimulation, microglia are capable polarizing toward proinflammatory M1 anti-inflammatory M2 phenotypes. In present study, we examined how aging affects microglial...

Infertility is a multifaceted condition influenced by metabolic and biochemical factors. Uric acid (UA) high-density lipoprotein cholesterol (HDL-C) may individually affect reproductive health. The UA-to-HDL-C ratio (UHR), an emerging indicator of chronic inflammation status, be associated with infertility because its connections to disorders, disrupted processes, other related Nevertheless, evidence the relationship between UHR remains limited controversial. Therefore, potential...

Breast cancer remains a significant global health challenge, with lung metastasis presenting critical barriers to effective treatment and patient survival. This study conducts the first comprehensive bibliometric visualized analysis of research in breast from 2000 2024, illustrating evolving trends collaboration patterns this area. Utilizing data Web Science Core Collection, we employed tools such as VOSviewer CiteSpace assess publication trends, international collaborations, influential...

Breast cancer is the most common gynecological malignancy and leading cause of cancer-related deaths in women. P-element induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are novel non-coding whose abnormal expressions have been closely associated with multiple cancers. This study explored roles possible mechanisms piRNA-31106 breast cancer.The expression tissues cells was detected by reverse transcription polymerase chain reaction (RT-PCR). The pcDNA vector containing...

Introduction Polycystic ovary syndrome (PCOS) is a common metabolic and endocrine disorder prevalent among women of reproductive age. Recent studies show that autophagy participated in the pathogenesis PCOS, including anovulation, hyperandrogenism, disturbances. This study was designed to screen autophagy-related genes (ATGs) may play pivotal role providing potential biomarkers identifying new molecular subgroups for therapeutic intervention. Methods Gene expression profiles PCOS control...

Endometriosis (EMs) is a life-long endocrine disorder and common cause for female infertility pelvic pain. The key characteristics of eutopic endometrium EMs patients are high proliferative migratory potentials. Cuproptosis recently identified copper- and-mitochondrial-dependent regulated cell death. Regretfully, its role in remains unclear. In this study, Kyoto Encyclopedia Genes Genomes analyses differentially expressed genes (DEGs) indicated strong activation the PI3K-Akt-mTOR pathway...

Propofol is a short-acting intravenous anesthetic agent with potential neuroprotective effect. In this study, we aim to investigate whether delayed propofol treatment protective against lipopolysaccharide (LPS)-stimulated inflammatory responses in microglial cells. Cultured BV2 cells were exposed at various time points after initiation of LPS stimulation. Nitrite production and cell viability assessed stimulation for 24 h. The effect on mRNA levels cyclooxygenase-2 (Cox-2), interleukin-6...

Although epilepsy is one of the most common neurologic disorders, there still a lack effective therapeutic drugs for it. Recently, we synthesized novel hydrogen sulfide (H2S) donor, which found to reduce seizures in animal models effectively. But it remains be determined its mechanism. In present study, that H2S donor could pilocarpine-induced mice. It alleviated epileptic behavior, hippocampal electroencephalography (EEG) activity seizures, and damage neurons status epilepticus addition,...

Colon cancer (CC) is one of the most common cancers with high morbidity globally. Ubiquitination involved in characterization multiple biological processes, and some ubiquitinated enzymes are associated prognosis CC. However, prognostic model ubiquitination-related genes (URGs) for CC unavailable.Gene expression data, somatic mutations, transcriptome profiles, microsatellite instability status (MSI) status, clinical information were obtained from The Cancer Genome Atlas (TCGA) dataset. Seven...

: Locally advanced breast cancer, which is defined as a malignant tumor that invades or adheres to the surrounding tissue, characterized by invasion of chest wall and skin surface tumor. Multiple lymph nodes are invaded fuse into mass, causing extensive axillary node metastasis. However, locally cancer does not exhibit distant At present, in most hospitals China rest world, this type primarily managed through systematic local treatments. consensus concerning optimal surgical method for...

Aim: It is to be elucidated the risk-predictive role of differentially expressed fatty acid metabolism related genes (DE-FRGs) in dilated cardiomyopathy (DCM) and myocardial infarction. Materials & methods: Four gene enrichment analyses defined DE-FRGs' biological functions pathways. Three strategies were applied identify risk biomarkers construct a nomogram. The 4-DE-FRG correlation with immune cell infiltration, drugs, ceRNA was explored. Results: DE-FRGs enriched lipid metabolism. A...

Shengchao Huang, Pu Qiu, Zhongzeng Liang, Zeming Yan, Kangwei Luo, Baoyi Liyan Yu, Julie Crèvecoeur, Alec Anthony Winder, Yuanqi Zhang, Haiping Jiang

Abstract Aims It is well established that exposure of common anesthetic isoflurane in early life can induce neuronal apoptosis and long‐lasting cognitive deficit, but the underlying mechanisms were not understood. The cell cycle protein Cyclin B1 plays an important role survival postmitotic neurons. In present study, we investigated whether cyclin B1‐mediated activation pathway a contributing factor developmental neurotoxicity. Methods Postnatal day 7 mice exposed to 1.2% for 6 hours. CR 8...

Chronic radiative chest wall ulcers are common in patients undergoing radiation therapy. If not treated early, then symptoms such as erosion, bleeding and infection will appear on the skin. In severe cases, invade ribs pleura, presenting a mortality risk. Small can be repaired with pedicle flaps. Because radioactive often thorax, surgeons need to remove large areas of skin muscle, sometimes ribs. Repairing defects challenge for surgeons.A 74-year-old female patient was admitted our...

In recent years, breast cancer is the most common malignancy in women. The traditional method of surgery to remove a woman's completely, which has negative impact on her work and life. Today, women have fiery pursuit maintain their perfect figure, forced surgeon find new surgical approach shape after surgery.This study systematically analyzed summarized incision design repair glandular defects early-stage patients by oncoplastic techniques. By summarizing methods (OBS) different quadrants,...

Misplacement of a left internal jugular vein puncture into the subclavian in patient with ECMO: case reportWeiqiang Huang1,Chuchu Yuan2,Baoyi Huang3,Xiaofeng Zhong1,Yadong Yang4,Xudong Liu1,Ming Hu1（Weiqiang Huang and Chuchu Yuan should be considered joint first author）Department Critical Care Medicine, Wuhan Pulmonary Hospital, Wuhan, Hubei, ChinaDepartment Tuberculosis Ward III, Anesthesiology, Yuebei People’s Shaoguan, Guangdong, Huanggang Central Hospital Yangtze University,Huanggang,...