A5102759206- Ferroptosis and cancer prognosis
- Inflammatory Bowel Disease
- Eating Disorders and Behaviors
- Obesity, Physical Activity, Diet
- CAR-T cell therapy research
- Obesity and Health Practices
- Cancer-related molecular mechanisms research
- Sports injuries and prevention
- Plant Gene Expression Analysis
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Glioma Diagnosis and Treatment
- Algal biology and biofuel production
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Helicobacter pylori-related gastroenterology studies
- Autophagy in Disease and Therapy
- Artificial Intelligence in Healthcare
- Immune cells in cancer
- Ginseng Biological Effects and Applications
- Multiple Myeloma Research and Treatments
- Consumer Attitudes and Food Labeling
- COVID-19 diagnosis using AI
- Nerve injury and regeneration
- Seaweed-derived Bioactive Compounds
Yancheng Central Blood Station
2025
Jilin University
2025
First Hospital of Jilin University
2025
Anhui University of Traditional Chinese Medicine
2022-2024
Beijing Technology and Business University
2021-2024
First Affiliated Hospital of Wannan Medical College
2023-2024
Southern Medical University
2023
Guangdong Provincial People's Hospital
2021-2023
Guangdong Academy of Medical Sciences
2021-2023
East China Normal University
2023
Inducing a full antitumor immune response in the tumor microenvironment (TME) is essential for successful cancer immunotherapy. Here, we report that an oncolytic adenovirus carrying mIL-15 (Ad-IL15) can effectively induce and inhibit growth mouse model of cancer. We found Ad-IL15 facilitated activation infiltration cells, including dendritic cells (DCs), T natural killer (NK) TME. Unexpectedly, observed also induced vascular normalization tertiary lymphoid structure formation Moreover,...
To evaluate the clinical value of association rule analysis for influencing factors donation related vasovagal reaction (DRVR), using Logistic regression as reference. A retrospective study was conducted on 10 000 unpaid blood donors from Zhangjiakou Central Blood Station June 2019 to 2021. Their baseline data collected. were divided into test group with DRVR (n=386) and control without (n=9614). performed all donors. The independent risk factor prediction established DRVR. Association...
Glioblastoma multiforme (GBM) is one of the most malignant tumors in brain with high morbidity and mortality. Mitophagy plays a significant role carcinogenesis, metastasis, invasion. In our study, we aim to construct mitophagy-related risk model predict prognosis GBM.RNA-seq data combined clinical information were downloaded from TCGA. The 4-gene nomograph was then constructed validated external cohort. Evaluation immune infiltration, functional enrichment tumor microenvironment (TME)...
Emerging evidence suggested that mitophagy may play an important role in the progression of hepatocellular carcinoma (HCC), whereas association between mitophagy-related genes and HCC patients’ prognosis remains unknown. In this study, we aimed to investigate potential prognostic values (MRGs) on patients at genetic level. According median immunoscore, categorized from TCGA cohort into two immune score groups, while 39 differential expression MRGs were identified. By using univariate...
Energy metabolism plays a crucial role in the improvement of heart dysfunction as well development failure (HF). The current study is designed to identify energy metabolism-related diagnostic biomarkers for predicting risk HF due myocardial infarction. Transcriptome sequencing data patients and non-heart (NF) people (GSE66360 GSE59867) were obtained from gene expression omnibus (GEO) database. differentially expressed genes (DEGs) screened between NF samples. subtyping consistency analysis...
Introduction Crohn’s disease is characterized of dysregulated inflammatory and immune reactions. The role the NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome in remains largely unknown. Methods microarray-based transcriptomic data corresponding clinical information GSE100833 GSE16879 were obtained from Gene Expression Omnibus (GEO) database. Identification NLRP3 inflammasome-related genes construction LASSO regression model. Immune landscape analysis was evaluated...
To investigate the risk factors and construct a prediction model of chronic atrophic gastritis (CAG) patients with intestinal metaplasia or dysplasia.The clinical data 450 CAG who were diagnosed treated in Department Gastroenterology Second Affiliated Hospital Anhui University Traditional Chinese Medicine from June 2016 to February 2022 collected. Single multiple logistic regression analysis used explore dysplasia training cohort. Then, we constructed predict onset based on cohort, following...
Background: Gastric intestinal metaplasia (IM) is the key link of gastric precancerous lesions. Ferroptosis a novel form programmed cell death. However, its impact on IM unclear. The focus this study to identify and verify ferroptosis-related genes (FRGs) that may be involved in by bioinformatics analysis. Materials methods: Differentially expressed (DEGs) were obtained from microarray dataset GSE60427 GSE78523 downloaded Gene Expression Omnibus (GEO) database. (DEFRGs) overlapping DEGs FRGs...
Phycocyanin, derived from marine algae, is known to have noteworthy antineoplastic properties. However, the underlying mechanism involved in phycocyanin-mediated anti-growth function on non-small cell lung cancer (NSCLC) cells still ambiguous. Here, we investigated of action phycocyanin H1299, A549, and LTEP-a2 cells. According results obtained, insulin receptor substrate 1 (IRS-1) expression was reduced by phycocyanin. Cell phenotype tests showed that siRNA knockdown IRS-1 significantly...
Non-small cell lung cancer (NSCLC) remains a leading cause of mortality worldwide. Phycocyanin, type marine food additives, has been reported to exert antineoplastic effects in NSCLC. The aim this study was investigate roles autophagy the anticancer process phycocyanin Results showed that increased LC3-II/LC3-I ratio and decreased p62 level NSCLC cells dose- time-dependent manner. Laser scanning confocal observation autophagic LC3 puncta promotes flux cells. In addition, AMPK signaling...
As a type of functional food additives, phycocyanin is well-known for its extraordinary antineoplastic activity in non-small cell lung cancer (NSCLC). Previously, high-throughput miRNA sequencing was employed to excavate miRNAs altered by A549 cells, while the in-depth regulatory mechanism inadequate. In this work, three significant up-regulated phycocyanin-treated cells are identified first time, including miR-3150a-3p, miR-6883-3p and miR-627-5p. Overexpression obviously diminished growth...
Abstract Objectives This study aims to evaluate the effect of coronavirus disease 2019 (COVID-19) on long-term risk digestive diseases in general population. Design Large-scale population-based cohort based a prospective cohort. Setting UK Biobank linked multiple nationwide electronic health records databases. Participants The consisted 112,311 individuals who survived initial 30 days following severe acute respiratory syndrome 2 (SARS-CoV-2) infection, as well two control groups:...
Background Gastric intestinal metaplasia(GIM) is an independent risk factor for GC, however, its pathogenesis still unclear. Ferroptosis a new type of programmed cell death, which may be involved in the process GIM. The purpose this study was to analyze expression ferroptosis-related genes (FRGs) GIM tissues and explore relationship between ferroptosis Method results tissue full transcriptome sequencing were downloaded from Gene Expression Omnibus(GEO) database. R software (V4.2.0) packages...
Head and neck squamous cell carcinoma (HNSC) is a dangerous cancer that represents an important threat to human health. Niclosamide anti-helminthic drug has received FDA approval. In repurposing screens, niclosamide was found inhibit proliferative activity for range of tumor types. Its functional effects in HNSC, however, have yet be established.
Abstract Background:The distribution of mucin phenotypes and its relationship with clinicopathological features in early differentiated gastric adenocarcinomas among the Chinese cohort is unknow. We aim to investigate analyze between features, especially biological behavior, from endoscopic specimens a cohort.Methods:Immunohistochemical staining CD10, MUC2, MUC5AC, MUC6 was performed 257 patients adenocarcinomas. Tumor location, gross type, tumor size, histological depth invasion,...
<title>Abstract</title> <bold>Background</bold>: Thirty-three synthetic driver genes of T-cell proliferation have recently been identified through genome-scale screening. However, the tumor microenvironment (TME) cell infiltration, prognosis, and response to immunotherapy mediated by multiple T proliferation-related (TRGs) in patients with head neck squamous carcinoma (HNSC) remain unclear. <bold>Methods</bold>: This study examined genetic transcriptional changes 771 HNSC analyzing TRGs from...