A5022069770- Pneumonia and Respiratory Infections
- Immune Response and Inflammation
- Bacterial biofilms and quorum sensing
- Cancer-related molecular mechanisms research
- interferon and immune responses
- Immune cells in cancer
- Nosocomial Infections in ICU
- Antimicrobial Peptides and Activities
- Respiratory Support and Mechanisms
- Influenza Virus Research Studies
- Renal Diseases and Glomerulopathies
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Viral Infections and Vectors
- COVID-19 Clinical Research Studies
- Viral Infections and Outbreaks Research
- Genomics, phytochemicals, and oxidative stress
- Immunotherapy and Immune Responses
- Inflammatory mediators and NSAID effects
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- Peptidase Inhibition and Analysis
- Probiotics and Fermented Foods
- Esophageal and GI Pathology
- Hepatitis B Virus Studies
Zhejiang University
2012-2025
Second Affiliated Hospital of Zhejiang University
2016-2025
Xi'an Jiaotong University
2021-2025
Qilu Hospital of Shandong University
2024
Nanjing University
2010-2024
Nanjing General Hospital of Nanjing Military Command
2010-2024
Hangzhou City University
2024
Dalian Medical University
2016-2024
China Medical University
2014-2024
Suzhou Municipal Hospital
2024
BackgroundThe progression of diabetic nephropathy (DN) is frequently determined by clinical parameters; however, the predictive value histologic lesions remains largely unknown. Our aim was to evaluate relationship between changes and renal outcome in patients with type 2 diabetes mellitus (T2DM).
Abstract A polarized macrophage response is presumed to have a pivotal role in variety of immunological pathophysiology. However, the molecular mechanism underlying functional shaping remains largely unknown. In this study, we reveal miR-127 development and thereby pathogenesis inflammation lung injury. particular, was demonstrated be prominently induced upon TLR engagement repressed by M2-prone cytokines. Enforced expression macrophages resulted significantly increased production...
Acute lung injury (ALI) is associated with excessive inflammatory response, leading to acute respiratory distress syndrome (ARDS) without timely treatment. A fewer effective drugs are available currently treat the ALI/ARDS. Herein, a therapeutic nanoplatform reactive oxygen species (ROS)-responsiveness was developed for regulation of inflammation. Dexamethasone acetate (Dex) encapsulated into poly(thioketal) polymers form polymeric nanoparticles (NPs) (PTKNPs@Dex). The NPs were composed...
Acute methicillin resistant Staphylococcus aureus (MRSA) pneumonia is one of the most frequently seen lung infection diseases with high morbidity and mortality. It urgent to explore an efficient antibacterial strategy owing increase drug resistance, virulence, pathogenicity MRSA. was found that Fe3O4 can induce ferroptosis in MRSA, but its effect inhibited by glutathione (GSH) a certain extent, while cinnamaldehyde (CA) enhance consuming GSH. As bacterial quorum sensing (QS) inhibitor, CA...
Recently, numerous evidence has revealed that excessive reactive oxygen species (ROS) production and mitochondrial disruption during acute lung injury (ALI) its most severe form, respiratory distress syndrome (ARDS) will aggravate the inflammatory process. To identify whether antioxidation can be one of treatment strategies this progress, we chose mitoQ, a mitochondria-targeted antioxidant was proved to effective in reducing ROS generated mitochondria, as scavenger investigate role ALI. We...
Abstract The widespread use of antibiotics has caused the rapid emergence antibiotic‐resistant bacterial strains and antibiotic resistance genes in past few decades. Photocatalytic inactivation, a promising approach for killing pathogens, efficiently avoids problems induced by antimicrobial drugs. However, traditional photocatalysts usually have some disadvantages, such as high costs raw materials, ultraviolet ray excitation, potential leaching toxic metals. Here, metal‐free heterojunction...
Abstract Non‐antibiotic strategies are desperately needed to treat post‐traumatic osteomyelitis (PTO) due the emergence of superbugs, complex inflammatory microenvironments, and greatly enriched biofilms. Previously, growing evidence indicated that quorum sensing (QS), a chemical communication signal among bacterial cells, can accelerate resistance under evolutionary pressure. This study aims develop medical dressing PTO by inhibiting QS regulating microenvironment, which includes severe...
Abstract The emergence of antibiotic‐resistant bacteria has exacerbated the challenge treating infectious diseases. Quorum sensing (QS), a bacterial communication system regulating virulence and biofilm formation, presents target for novel therapies. Cuproptosis death is innovation mode death, however, this effect may be partially inhibited by glutathione (GSH). Buthionine sulfoximine (BSO) responsible GSH biosynthesis been identified as potential promoter cuproptosis death. Here, Cu 2 O‐BSO...
Macrophage polarization is critical for dictating host defense against pathogens and injurious agents. Dysregulation of macrophage differentiation has been implicated in infectious inflammatory diseases. Here, we show that protein kinase B/Akt1 signaling induced by Staphylococcus aureus essential shifting macrophages from an antimicrobial phenotype (M1) to a functionally inert signature. Akt1−/−mice consistently had enhanced bacterial clearance greater survival, compared with their wild-type...
Obesity-related glomerulopathy (ORG) is an increasing cause of end-stage renal disease, but evidence concerning the effects treatments rather limited. This study was aimed at exploring renoprotective weight loss on patients with ORG.A total 63 biopsy-proven ORG had food and exercise intervention in physician-supervised program were divided into three groups basis percentage change from baseline to follow-up: significant (>3% reduction body mass index [BMI]), stable weight, or gain increase)....
Aim: Allopurinol is widely used as an effective urate-lowering drug and one of the most frequent causes cutaneous adverse reactions (cADRs). Recently, a strong association HLA-B*58:01 with allopurinol-induced severe cADRs was identified. This study investigated predisposition to different types allopurinol-cADRs conferred by HLA-B*5801 in Han population from mainland China. Patients & methods:HLA-B genotyping performed on 38 Chinese patients 2008 2011. Results: All allopurinol-cADR carried...
Secondary bacterial pneumonias are a frequent complication of influenza and other respiratory viral infections, but the mechanisms underlying viral-induced susceptibility to infections poorly understood. In particular, it is unclear whether host's response against infection, independent injury caused by virus, results in impairment antibacterial host defense. Here, we sought determine induction an "antiviral" immune state using various recognition receptor ligands was sufficient result...
Aim of this study was to develop a new simpler and more effective severity score for community-acquired pneumonia (CAP) patients. A total 1640 consecutive hospitalized CAP patients in Second Affiliated Hospital Zhejiang University were included. The effectiveness different scores predict mortality compared, the performance validated on an external cohort 1164 with admitted teaching hospital Italy. Using age ≥ 65 years, LDH > 230 u/L, albumin < 3.5 g/dL, platelet count 100 × 10(9)/L,...
We have previously demonstrated that exosomes from dendritic cells (DCs) secreting TGF‐β1 (sTGF‐β1‐EXOs) delay the development of murine inflammatory bowel disease (IBD). In this study, we isolated DCs expressing membrane‐associated (mTGF‐β1‐EXOs) and found mTGF‐β1‐EXOs had more potent immunosuppressive activity than sTGF‐β1‐EXOs in vitro. Treatment mice with inhibited progression myelin oligodendrocyte glycoprotein (MOG) peptide‐induced EAE even after onset. also impaired Ag‐specific Th1...
Abstract Low T3 syndrome was previously reported to be linked poor clinical outcomes in critically ill patients. The aim of this study evaluate the predictive power low for patients with community-acquired pneumonia (CAP). Data 503 were analyzed retrospectively and primary end point 30-day mortality. intensive care unit (ICU) admission rate mortality 8.3% 6.4% respectively. prevalence differed significantly between survivors nonsurvivors (29.1% vs 71.9%, P < 0.001) associated a remarkable...
Bacterial pneumonia is one of the most challenging global infectious diseases with high morbidity and mortality. Considering antibiotic abuse resistance bacterial biofilms, a variety metal-based materials have been developed. However, due to oxygen environment lungs, some aerobic infection bacteria tolerance ROS, based on ROS may not achieve good therapeutic effects. Inspired by sensitivity cuproptosis respiratory cells, we designed copper composite antibacterial nanoparticle found that it...
Accumulating data suggested that functional expression of Toll-like receptors (TLRs) in tumor cells was involved progression. Our previous study demonstrated TLR9 signaling could enhance the progression human lung cancer vitro and vivo. We further showed miR-574-5p mostly up-regulated miRNA under by array analysis. Here we characterized potential role miRNA-574-5p enhanced induced cancer. confirmed effectively elevated cells. Notably, found down-regulation using inhibitor or sponge vivo...
Multifunctional antimicrobial strategies are urgently needed to treat methicillin-resistant Staphylococcus aureus (MRSA) caused pneumonia due its increasing resistance, enhanced virulence, and high pathogenicity. Here, we report that lysostaphin, a bacteriolytic enzyme, encapsulated within poly(lactic-co-glycolic acid) microspheres (LyIR@MS) specially treats planktonic MRSA bacteria, mature biofilms, related pneumonia. Optimized LyIR@MS with suitable diameters could deliver sufficient amount...