A5020192808- Chromatography in Natural Products
- Phytochemistry and biological activity of medicinal plants
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Bioactive Compounds and Antitumor Agents
- Cancer Mechanisms and Therapy
- Immune cells in cancer
- Advanced Welding Techniques Analysis
- Flavonoids in Medical Research
- Welding Techniques and Residual Stresses
- Healthcare and Venom Research
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- TGF-β signaling in diseases
- Hepatitis B Virus Studies
- Tryptophan and brain disorders
- Cancer, Lipids, and Metabolism
- Aldose Reductase and Taurine
- Nanoplatforms for cancer theranostics
- Traditional Chinese Medicine Studies
- Forensic Fingerprint Detection Methods
- Sphingolipid Metabolism and Signaling
- Systemic Lupus Erythematosus Research
- Cancer, Stress, Anesthesia, and Immune Response
Second Military Medical University
2016-2025
Changhai Hospital
2016-2023
Ming Chi University of Technology
2022
Background: Hypoxia plays an important role in the lung metastasis of hepatocellular carcinoma (HCC). However, process by which hypoxia promotes formation a pre-metastatic niche (PMN) and its underlying mechanism remain unclear. Methods: Exosomes derived from normoxic hypoxic HCC cells were collected to induce fibroblast activation vitro PMN vivo. The micro RNA (miR) profiles exosomes sequenced identify differentially expressed miRNAs. Gain- loss-of-function analyses performed investigate...
In this study, we investigated whether melittin could suppress hypoxia-induced vasculogenic mimicry (VM) formation in liver cancer and explored the underlying mechanisms. Melittin significantly inhibited proliferation of cells with or without CoCl2 presence. also CoCl2-induced migration, invasion, VM cells. treatment suppressed expression E-cadherin elevated N-cadherin Vimentin. reversed changes protein mRNA levels these epithelial-mesenchymal transition (EMT) markers. accumulation HIF-1α...
A hypoxic microenvironment may induce angiogenesis and promote the development of hepatocellular carcinoma (HCC). The aim this study was to evaluate whether ursodeoxycholic acid (UDCA) inhibit HCC cell-induced possible mechanisms.
Emodin, an anthraquinone derivative from the root and rhizome of Rheum palmatum L., was found to have antitumor effects in different types cancer by regulating multi-molecular targets. The aim present study explore effect emodin on migration invasion MHCC-97H human hepatocellular carcinoma cells underlying molecular mechanisms. Firstly, it demonstrated that can inhibit cell proliferation induce apoptosis a time- dose-dependent manner, using MTT assay flow cytometry, respectively. However,...
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. In China, traditional Chinese herb medicine has been widely used in treatment HCC. Jiedu Recipe (JR) a prescription which shown good results against However, exact mechanisms JR are still unknown. Therefore, we investigated efficacy on HCC current study. inhibited cell viability both SMMC-7721 and Huh7 cells time- dose-dependent manners. Transwell assay revealed that decreased number migrated cells....
Transcatheter arterial chemoembolization (TACE) is one of the effective treatment methods for hepatocellular carcinoma (HCC) in middle and late phases. However, TACE-induced hypoxia may promote angiogenesis section some cytokines, such as IL-8, and, thereby, lead to tumor metastasis. Therefore, we investigated effect Jiedu Recipe (JR), which has been demonstrated an Traditional Chinese Medicine (TCM) recipe on HCC, cytokines upregulation hypoxia-induced angiogenesis. A total 88 patients...
In order to find the predictive indexes for metabolic syndrome (MS), a data mining method was used identify significant physiological and traditional Chinese medicine (TCM) constitutions.The annual health check-up including physical examination data; biochemical tests Constitution in Medicine Questionnaire (CCMQ) measurement from 2014 2016 were screened according inclusion exclusion criteria. A matrix established by longitudinal of three consecutive years. TreeNet machine learning algorithm...
Ginsenosides Rb1, Rh1, Rg1 and Rg3 are known as the main active components extracted from roots of Panax ginseng C.A. Meyer, were reported to have immunoregulatory effects. Disruption B-cell immune regulation during pathogenesis systemic lupus erythematosus (SLE) may lead production large amounts antibodies. The present study investigated effects four ginsenoside monomers on observed that they inhibited proliferation secretion B cells induced by LPS, caused an upregulation expression...
The assessment of fingerprint image quality is critical for most applications. It has an impact on the performance and compatibility recognition, authentication, built-in cryptosystems. This paper developed improved derived from power spectrum approach combined it with Prewitt filter weighting method. conventional our proposed were implemented accuracy reliability tests using good, faulty, blurred images. experimental results showed algorithm accurately identified sharpness images average...
Emodin is one of the main active ingredient Rheum palmatum, and has anti-inflammatory, anti-bacterial, anti-viral other effects. In recent years, it arouse concern since a significant anti-tumor effect with low toxicity. this paper we mainly report anti-cancer effects emodin according to studies past five including four parts such as inhibit tumor growth, migration invasion, enhance efficacy combination therapy, increase chemosensitivity attenuated side We hope that our work may provide...
Copper/steel dissimilar tube joint has been widely used in manufacturing industries due to the combination of high tensile strength and heat conductivity. In this paper, experimental numerical methods are carried out analyze interface formation defect elimination mechanism during electromagnetic pulse welding T2 304L tube. The research shows that morphology is divided into four zones containing end unwelded zone, first welded central second zone different impact speed angle initial process,...