A5090901464- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Immune cells in cancer
- Sphingolipid Metabolism and Signaling
- Plant-based Medicinal Research
- Genomics, phytochemicals, and oxidative stress
- RNA and protein synthesis mechanisms
- Tryptophan and brain disorders
- CRISPR and Genetic Engineering
- interferon and immune responses
- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Toxin Mechanisms and Immunotoxins
- Molecular Biology Techniques and Applications
- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
- Hepatitis B Virus Studies
- Cancer Mechanisms and Therapy
- Virus-based gene therapy research
- Cervical Cancer and HPV Research
- Phagocytosis and Immune Regulation
- Liver Disease Diagnosis and Treatment
- Phytochemical compounds biological activities
- Neuroinflammation and Neurodegeneration Mechanisms
Second Military Medical University
2017-2023
Changhai Hospital
2017-2020
VCU Massey Comprehensive Cancer Center
2010
Max Delbrück Center
2002
Background: Hypoxia plays an important role in the lung metastasis of hepatocellular carcinoma (HCC). However, process by which hypoxia promotes formation a pre-metastatic niche (PMN) and its underlying mechanism remain unclear. Methods: Exosomes derived from normoxic hypoxic HCC cells were collected to induce fibroblast activation vitro PMN vivo. The micro RNA (miR) profiles exosomes sequenced identify differentially expressed miRNAs. Gain- loss-of-function analyses performed investigate...
High risk human papillomaviruses (HPVs) are central to the development of cervical cancer and deregulated expression high HPV oncogenes is a critical event in this process. Here, we find that cell protein nucleolin binds sequence-specific manner HPV18 enhancer. The DNA binding activity primarily S phase specific, much like transcription E6 E7 oncoproteins cells. Antisense inactivation blocks oncogene selectively decreases HPV18+ growth. Furthermore, controls chromatin structure In contrast,...
Iron overload (IO) is accompanied by hepatic inflammation. The chemokine (C-C motif) ligand 2 (CCL2) mediates inflammation, and its overexpression associated with IO. However, whether IO results in CCL2 the liver underlying mechanisms are unclear.We subjected mice to administering intraperitoneal injections of dextran-iron or feeding a 3% diet observe effects on miR-122/CCL2 expression through real-time qPCR Western blot analysis. We also used indicators, including inflammatory cytokine,...
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and, in its advanced stages, has a 5-year survival rate only 3% to 5%. Despite novel mechanisms and treatments being uncovered over past few years, effective strategies for HCC are currently limited. Previous studies have proven that aconite can suppress tumor growth progression prevent recurrence metastasis multiple cancers, but underlying molecular largely unknown. In this study, different doses were applied...
Hematopoietic gene delivery, such as hematopoietic stem/progenitor cells (HSPCs), is a promising treatment for both inherited and acquired diseases, hemophilia. Recently, combined strategy to achieve more than 90% transduction efficiency was documented using recombinant adeno-associated virus serotype 6 (rAAV6) vectors. However, the mechanisms of enhanced vector in are largely unknown. In this manuscript, we first reported that proteasome inhibitors, which well-known facilitate rAAV...