A5103139495- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Insect symbiosis and bacterial influences
- Gastric Cancer Management and Outcomes
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Ginseng Biological Effects and Applications
- Cancer Immunotherapy and Biomarkers
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Insect-Plant Interactions and Control
- Economic and Financial Impacts of Cancer
- Lipid metabolism and disorders
- Neuroblastoma Research and Treatments
- Pain Management and Placebo Effect
- Liver Disease Diagnosis and Treatment
- Complementary and Alternative Medicine Studies
- Natural product bioactivities and synthesis
- PARP inhibition in cancer therapy
- Melanoma and MAPK Pathways
- Algal biology and biofuel production
- Biosimilars and Bioanalytical Methods
- Cholinesterase and Neurodegenerative Diseases
- Renal cell carcinoma treatment
81th Hospital of PLA
2016-2022
Nanjing University of Chinese Medicine
2015-2022
Jinling Institute of Technology
2020
Nanjing General Hospital of Nanjing Military Command
2020
Nanjing Agricultural University
2017-2018
Columbia University
2015
University of Zurich
2009
The aggregation of the amyloid-β (Aβ) peptide plays a pivotal role in pathogenesis Alzheimer9s disease, as soluble oligomers are intimately linked to neuronal toxicity and inhibition hippocampal long-term potentiation (LTP). In C-terminal region Aβ there three consecutive GxxxG dimerization motifs, which we could previously demonstrate play critical generation Aβ. Here, show that glycine 33 (G33) central interaction motif within hydrophobic sequence is important for dynamics peptide....
Abstract Background HER3 (ErbB3), a member of the human epidermal growth factor receptor family, is frequently overexpressed in various cancers. Multiple HER3-targeting antibodies and antibody–drug conjugates (ADCs) were developed for solid tumor treatment, however none agent has been approved therapy yet. We DB-1310, ADC composed novel humanized anti-HER3 monoclonal antibody covalently linked to proprietary DNA topoisomerase I inhibitor payload (P1021), evaluate efficacy safety DB-1310...
Ginsenoside Rg3, a natural compound, has been reported to function as an anticancer agent for hepatoma carcinoma, while the mechanisms underlying effects are not clear. Therefore, objective of our study was explore impact RG3 on cell migration and invasion by regulating lncRNA HOX antisense intergenic (HOTAIR) expression involving PI3K/AKT signaling pathway. qRT-PCR utilized measure mRNA HOTAIR. Furthermore, HOTAIR overexpression plasmids were transfected SMMC-7721 SK-Hep-1 cells....
Background: EGFR and HER3 are co-overexpressed in a spectrum of tumors, including lung, breast, gastrointestinal, renal cell, ovarian, bladder, prostate cancers. Importantly, expression is further enhanced upon inhibition EGFR, suggesting that simultaneous targeting both could enhance tumor selectivity improve therapeutic efficacy tyrosine kinase inhibitors resistant tumors. This hypothesis has been supported by the clinical data BL-B01D1, bispecific ADC currently development. Here, we...
Introduction: B cell maturation antigen (BCMA) overexpression has been found on the surface of malignant plasma cells in bone marrow multiple myeloma (MM) patients. In recent years, innovative medicines targeting BCMA such as antibody-drug conjugates (ADC), T-cell engager and CAR-T have made great progress treatment MM Among them, belantamab mafodotin approved by FDA. However, a significant fraction patients does not respond, or respond for short period time, to mafodotin. Thus, there...
The present study aims to investigate the effects of ginsenoside Rg3 combined with oxaliplatin on proliferation and apoptosis hepatocellular carcinoma cells related mechanism. In this study, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was applied examine rate cell SMMC-7721 different treatment. Flow cytometry performed Immunofluorescence Western blot methods were used evaluate expressions proliferating nuclear antigen (PCNA) cyclin D1 in groups. We found that...
Immune checkpoint inhibitor (ICI)-associated myocarditis is a rare and potentially fatal immune-related adverse event (irAE). The study aimed to observe the occurrence of caused by ICIs.The clinical manifestations, diagnosis, treatment immune were explored through retrospective analysis detailed data typical ICI-associated from our center literature review.From January 1, 2018, December 31, 2019, total 283 patients treated with PD-1 or PD-L1 monoclonal antibodies (McAbs) alone combination...
Pancreatic cancer is one of the leading causes cancer-related mortality in both developed and developing countries. The incidence pancreatic China accounts for about a quater global incidence, epidemiological characteristics therapeutic strategies differ due to social, economic, cultural, environmental, public health factors. Non-domestic guidelines do not reflect clinicopathologic treatment patterns Chinese patients. Thus, 2018, Society Clinical Oncology (CSCO) organized panel senior...
Delta-like ligand 3 (DLL3) is highly expressed on the cell surface of small lung cancer (SCLC), one most lethal malignancies, but minimally or not in normal tissues, making it an attractive target for SCLC. However, none DLL3-targeting antibody-drug conjugates (ADCs) have been approved SCLC therapy yet. We developed DB-1314, new anti-DLL3 ADC composed a novel humanized monoclonal antibody (DB131401) conjugated with eight molecules P1021 (topoisomerase I inhibitor), and described its...
Abstract In laboratories, the parasitism rate of Ostrinia furnacalis (Güenée) (Lepidoptera: Crambidae) eggs by Trichogramma dendrolimi Matsumura (Hymenoptera: Trichogrammatidae) is low; however, efforts to control O. with T. in field have been successful. this study, effects number attacks against and diet larva on wasp development were investigated. The results indicated that more increased significantly not only successful , but also percentage host failed develop into either larvae or ....
Endostar, a modified recombinant human endostatin, inhibits the growth of variety tumors by suppressing neovascularization. Vascular endothelial factor (VEGF) has an important role in malignant ascites formation. In order to determine whether Endostar can suppress formation and prolong survival times, mouse models were established using S180 H22 tumor cells. The experimental mice randomly divided into four groups: three treatment groups received different doses (4, 8 16 mg/kg), control group...
Abstract Objectives Blood dendritic cell antigen 2 (BDCA2) is exclusively expressed on plasmacytoid cells (pDCs) whose uncontrolled production of type I IFN (IFN-I) crucial in pathogenesis SLE and other autoimmune diseases. Although anti-BDCA2 antibody therapy reduced disease activity patients, its clinical efficacy needs further improvement. We developed a novel glucocorticoid receptor agonist used it as payload to conjugate with an form BDCA2 antibody–drug (BDCA2-ADC). The activation...
Objective . To explore whether acupuncture and moxibustion can prevent disease progression of advanced gastric cancer patients completing second‐line chemotherapy and, if so, the related mechanism. Method Progression‐free survival (PFS) overall (OS) were main outcome measures. The real‐time quantitative PCR was used to detect expression genes including T‐bet, IFN‐ γ , GATA3, IL‐4 in peripheral blood mononuclear cells (PBMCs). IL‐4, IL‐6, Ca199, CRP, plasma levels checked. Results 170...
The aim of this study was to observe the efficacy and safety apatinib combined with toptecan therapy in multiline treatment platinum-resistant recurrent ovarian cancer patients. clinical records three patients treated were analyzed followed up for 3 months, related literatures reviewed. achieved partial response tumor marker CA125 levels decreased significantly as an outcome treatment. Major adverse reactions hypertension, hand-foot skin reaction, anemia, which manageable medication....
The identification of Trichogramma (Hymenoptera: Trichogrammatidae) species is problematic due to their small size and lack distinct morphological characters. In this study, we combined characters the male genitalia molecular methods using mitochondrial cytochrome oxidase I (COI) gene as a marker identify eight from 16 geographic populations: T. evanescens Westwood, cacoeciae Marchal, ostriniae Pang et Chen, chilonis Ishii, japonicum Ashmead, brassicae Bezdenko, bilingensis He Pang,...
Abstract Background: HER3 (ErbB3), a member of the human epidermal growth factor receptor family, is frequently overexpressed in various cancers. Its high expression associated with poor prognosis several solid tumors. Many anti-Her3 antibodies have been developed for cancer therapy. To date, only patritumab deruxtecan (U3-1402) showed clinical efficacy both NSCLC and breast among all Her3-targeting therapies. DB-1310 ADC composed novel humanized immunoglobulin G1 (IgG1) monoclonal antibody,...
Abstract Study Objective: BDCA2 is specifically expressed on plasmacytoid dendritic cells (pDCs), whose overproduction of type I IFN crucial in SLE pathogenesis. Combining anti-BDCA2 mAB with glucocorticoids (GCs) has shown clinical efficacy. Previous studies revealed superior anti-inflammatory effects antibody‒drug conjugate (ADC), motivating the development DB-2304, an ADC using a novel glucocorticoid receptor agonist as payload. This study assessed preclinical efficacy and safety DB-2304....
Abstract Introduction: B7-H3 (CD276) is an immunomodulatory protein of the B7 superfamily molecules, it overexpressed in a wide range solid tumors. overexpression often correlates with poor survival and higher tumor grade, has become attractive target for development novel cancer therapies recently. targeting antibody-drug conjugates (ADCs), such as MGC018 DS7300a, have shown preliminary clinical efficacy. DB-1311 ADC comprised humanized antibody conjugated to DNA topoisomerase I inhibitor...