A5100735904- Mesoporous Materials and Catalysis
- Zeolite Catalysis and Synthesis
- Nanoparticles: synthesis and applications
- Metal-Organic Frameworks: Synthesis and Applications
- Graphene and Nanomaterials Applications
- Cancer Research and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Advanced Cellulose Research Studies
- Wound Healing and Treatments
- Catalytic Processes in Materials Science
- Chemical Synthesis and Characterization
- Berberine and alkaloids research
- Parasites and Host Interactions
- Advanced ceramic materials synthesis
- Nanoplatforms for cancer theranostics
- Cell death mechanisms and regulation
- Catalysis and Hydrodesulfurization Studies
- Surface Modification and Superhydrophobicity
- Autophagy in Disease and Therapy
- Natural product bioactivities and synthesis
- Nanocomposite Films for Food Packaging
- Block Copolymer Self-Assembly
- Pharmacogenetics and Drug Metabolism
- Carbon and Quantum Dots Applications
- Plant biochemistry and biosynthesis
China Pharmaceutical University
2015-2025
Hubei University of Arts and Science
2024
Xiangyang Central Hospital
2024
Huazhong University of Science and Technology
2024
Hubei University of Education
2024
Hefei University of Technology
2024
Nanjing General Hospital of Nanjing Military Command
2020-2023
State Key Laboratory of Natural Medicine
2021-2023
Nanjing University
2011-2023
Jinling Institute of Technology
2023
In this work, we report a facile and green approach to prepare uniform silver nanoparticles (AgNPs) decorated graphene oxide (GO) nanocomposite (GO-Ag). The was fully characterized by transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectra, ultraviolet–visible (UV–vis) absorption X-ray photoelectron spectroscopy (XPS), which demonstrated that AgNPs with diameter of approximately 22 nm were uniformly compactly deposited on GO. To investigate the ion release...
In this study, we report the design and fabrication of a novel biocompatible sponge with excellent antibacterial property, making it promising material for wound dressings. The is formed by grafting amoxicillin onto regenerated bacterial cellulose (RBC). It was observed that grafted RBC could enhance activity against fungus, Gram-negative, Gram-positive bacteria. morphology strains treated fluorescent stain results further demonstrated ability fabricated sponge. Moreover, cytocompatibility...
Bacterial cellulose/graphene oxide composites have excellent anti-bacterial activities and good compatibility.
γ-Fe2O3 nanotube/porous reduced graphene oxide (rGO) composites were prepared using a controllable method. Uniform nanotubes with diameter of about 85 nm and length 230 are well distributed between porous rGO sheets. Compared the nanorod/porous nanotube/nonporous rGO, both unique hollow structure show an advantage for attenuation microwaves. The appropriate dielectric loss magnetic result in good impedance matching. minimum reflection composite reaches −34.20 dB thickness 2.0 mm, absorption...
The aim of this study was to prepare nonleaching chitosan based wound dressings via chemical modification. A green and facile method applied fabricate ampicillin grafted (CSAP) sponges. morphology, porosity, swelling behavior CSAP sponges were analyzed. Specifically, the antibacterial activity toward Staphylococcus aureus, Candida albicans, Escherichia coli assessed using a series assays, including bacterial growth curve, nucleic acids leakage, live/dead staining. As expected, exhibit...
The weakened tumour colonization of attenuated Salmonella has severely hampered its clinical development.In this study, we investigated whether an anti-inflammation and antiangiogenesis compound triptolide could improve the efficacy VNP20009, a highly strain, against mice melanoma.By comparing effects conventional VNP20009 monotherapy combination therapy that uses both found significantly improved by reducing number infiltrated neutrophils in melanoma, which led to larger necrotic area...
mediated cancer therapy has achieved remarkable anti-tumor effects in experimental animal models, but the detailed mechanism remains unsolved. In this report, active involvement of host immune response process was confirmed by comparing tumor-suppressive Salmonella immunocompetent and immunodeficient mice bearing melanoma allografts. Since flagella are key inducers during bacterial infection, were genetically disrupted to analyse their Salmonella-mediated therapy. The results showed that...
Attenuated Salmonella typhimurium ( S. ) strains can selectively grow and express exogenous genes in tumors for targeted therapy. We engineered strain VNP20009 to secrete tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) under the control of a hypoxia‐induced nirB promoter examined efficacy Salmonella‐ mediated expression TRAIL mice bearing melanoma TRAIL‐resistant RM‐1 tumor. found that VNP preferentially accumulated tissues effectively drove TRAIL. Compared with recombinant...
Artemisinins have been reported to diverse functions, such as antimalaria, anticancer, anti-inflammation, and immunoregulation activities. DC32, a dihydroartemisinin derivative possessing potent immunosuppressive properties, was found in our previous study. In this study, the antirheumatic effect underlying mechanisms of DC32 were investigated. The results showed that could markedly alleviate footpad inflammation, reduce cartilage degradation, activate Nrf2/HO-1 signaling pathway, increase...
Silicalite-1 monolayers on α-Al2O3 supported polymer thin films with strong zeolite-polymer bonding, high surface coverage, uniform orientation in b-axis, and easy control of assembly could be manufactured by the stacking sonication or simpler manual (see figure). The methodology can further applied to monolayer various nano- micro-sized particles hydroxyl groups porous solid films. Supporting information for this article is available WWW under...
Bone cancer pain is a challenge for its not completely clarified mechanism and broad clinical morbidity. Therefore, novel more effective drugs are urgent needed improvement of patients' quality life. Glutamate receptors have been associated with the development central sensitization chronic pain. Inhibition N-methyl-d-aspartate (NMDA) metabotropic glutamate (mGlu) can effectively attenuate bone pain, respectively. Herein, our results indicated that levo-Corydalmine (l-CDL), compound from...
Abstract Dihydroartemisinin (DHA) and its analogs are reported to possess selective anticancer activity. Here, we a novel DHA derivative DHA-37 that exhibited more potent activity on the cells tested. Distinct from DHA-induced apoptosis, triggered excessive autophagic cell death, became main contributor DHA-37-induced A549 death. Incubation of with but not produced increased dots distribution GFP-LC3 expression ratio LC3-II/LC3-I, enhanced formation vacuoles as revealed by TEM. Treatment...
Immune checkpoint inhibitor (ICI)-associated myocarditis is a rare and potentially fatal immune-related adverse event (irAE). The study aimed to observe the occurrence of caused by ICIs.The clinical manifestations, diagnosis, treatment immune were explored through retrospective analysis detailed data typical ICI-associated from our center literature review.From January 1, 2018, December 31, 2019, total 283 patients treated with PD-1 or PD-L1 monoclonal antibodies (McAbs) alone combination...