A5101984724- Cancer Research and Treatments
- Nanoplatforms for cancer theranostics
- Virus-based gene therapy research
- Cancer, Hypoxia, and Metabolism
- CAR-T cell therapy research
- Cancer Genomics and Diagnostics
- Parallel Computing and Optimization Techniques
- Immune cells in cancer
- Genomics and Phylogenetic Studies
- Congenital Diaphragmatic Hernia Studies
- Cytokine Signaling Pathways and Interactions
- Parasites and Host Interactions
- Adenosine and Purinergic Signaling
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Chemokine receptors and signaling
- Drug Transport and Resistance Mechanisms
- Reproductive Biology and Fertility
- Reproductive Health and Technologies
- Phytase and its Applications
- Renal and related cancers
- Parasitic Infections and Diagnostics
- Molecular Biology Techniques and Applications
- Hepatitis Viruses Studies and Epidemiology
- Chronic Kidney Disease and Diabetes
Powerchina Huadong Engineering Corporation (China)
2024
PowerChina (China)
2024
Nanjing University
2009-2021
First Affiliated Hospital of Nanchang University
2021
Nanchang University
2021
Kunming Medical University
2020
Taian City Central Hospital
2016
Army Medical University
2012
Southwest Hospital
2012
Pharmaceutical Biotechnology (Czechia)
2009-2011
The weakened tumour colonization of attenuated Salmonella has severely hampered its clinical development.In this study, we investigated whether an anti-inflammation and antiangiogenesis compound triptolide could improve the efficacy VNP20009, a highly strain, against mice melanoma.By comparing effects conventional VNP20009 monotherapy combination therapy that uses both found significantly improved by reducing number infiltrated neutrophils in melanoma, which led to larger necrotic area...
mediated cancer therapy has achieved remarkable anti-tumor effects in experimental animal models, but the detailed mechanism remains unsolved. In this report, active involvement of host immune response process was confirmed by comparing tumor-suppressive Salmonella immunocompetent and immunodeficient mice bearing melanoma allografts. Since flagella are key inducers during bacterial infection, were genetically disrupted to analyse their Salmonella-mediated therapy. The results showed that...
Tumor-associated macrophages (TAMs) in the tumor microenvironment contribute to poor prognosis gastric cancer (GC). However, underlying mechanism by which TAMs promote GC progression and metastasis remains elusive. Expression of POU1F1 was detected 60 matched GC-normal tissue pairs using qRT-PCR immunohistochemistry (IHC) analysis. The correlation between clinical-pathological factors patients were further assessed. Cell proliferation monitored CCK-8, colony formation,...
Attenuated Salmonella typhimurium ( S. ) strains can selectively grow and express exogenous genes in tumors for targeted therapy. We engineered strain VNP20009 to secrete tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) under the control of a hypoxia‐induced nirB promoter examined efficacy Salmonella‐ mediated expression TRAIL mice bearing melanoma TRAIL‐resistant RM‐1 tumor. found that VNP preferentially accumulated tissues effectively drove TRAIL. Compared with recombinant...
Tumor-targeting bacteria have been developed as powerful anticancer agents. Salmonella typhimurium VNP20009, a representative tumor-targeting strain, has systemically administered single-agent therapy at doses of 1 x 10(6) to 3 colony-forming unit (cfu)/mouse, or in combination with other antitumor agents 10(4) 2 10(5) cfu/mouse. Recently, we reported that oral delivery VNP20009 the dose 10(9) cfu/mouse induced significant effects comparable by systemic administration this strain To further...
Solid tumors often contain hypoxic and necrotic areas that can be targeted by attenuated Salmonella typhimurium VNP20009 (VNP). We sought to develop a hypoxia- inducible promoter system based on the tumor-specific delivered strain VNP confine expression of therapeutic gene specifically or selectively within tumor microenvironment. A hypoxia-inducible - adhE was screened from hypoxia-regulated endogenous proteins through two-dimensional gel electrophoresis matrix-assisted laser desorption...
Background Schistosomiasis japonica is a zoonotic parasitic disease and oral vaccine delivery system would be benefit for prevention of this disease. Although attenuated salmonella has been used as an antigen expression vector development, the membrane-bound vacuoles in which bacteria reside hinders presentation expressed heterologous antigens to major histocompatibility complex (MHC) molecules. The present work Salmonella typhimurium strain VNP20009 secretory Sj23LHDGST bivalent from...
Attenuated Salmonella typhimurium (S. typhimurium) strain VNP20009 has been employed as a powerful anticancer agent due to its selective accumulation in tumors for targeted therapy. S. demonstrated constitute delivery tool carrying antiangiogenic or proapoptotic genes that treat cancer. The hydrodynamic tail vein (HTV) injection of naked plasmid DNA developed an effective gene strategy, which successfully used vivo. aim this study was develop combination therapy and HTV interleukin-21...
Immunotherapy with tumor lysate-pulsed dendritic cells (DCs) is one of the breakthrough strategies used in treatment cancer. However, DC-based immunotherapies for osteosarcoma are limited. In present study, preclinical studies a C3H mouse model (produced by subcutaneous injection LM8 murine cells) validated concept that cell bone marrow-derived DCs may evoke more potent immune response compared have been matured using polyinosinic:polycytidylic acid (poly I:C). A cytotoxic T lymphocyte (CTL)...
e13655 Background: The reactivation of telomerase reverse transcriptase ( TERT) is one the characters that make cancer cells immortal. TERT expression has been shown in various human cancers.However, landscape alterations Chinese patients with solid tumors still remains unclear. Here, we illustrated profile variations tumor by using next generation sequencing (NGS)-based targeted sequencing. Methods: Formalin fixed, paraffin embedded (FFPE) tissues and matching blood samples were collected...