A5012890681- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Mechanisms of cancer metastasis
- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Geochemistry and Geologic Mapping
- Circular RNAs in diseases
- Gallbladder and Bile Duct Disorders
- Geological and Geochemical Analysis
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Cell Adhesion Molecules Research
- HER2/EGFR in Cancer Research
- Cancer Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Advanced Drug Delivery Systems
- Head and Neck Cancer Studies
- Pancreatic and Hepatic Oncology Research
- COVID-19 epidemiological studies
- Hepatitis B Virus Studies
- Vaccine Coverage and Hesitancy
- COVID-19 Pandemic Impacts
Kunming Medical University
2011-2025
Wuhan University
2005-2025
Zhongnan Hospital of Wuhan University
2020-2025
Sun Yat-sen University Cancer Center
2024
Affiliated Hospital of Qingdao University
2017-2024
Qingdao University
2017-2024
Sun Yat-sen University
2024
Hefei Institute of Technology Innovation
2024
Shenzhen Institutes of Advanced Technology
2024
Chinese Academy of Sciences
2024
Background/Aims: Doublecortin-like kinase 1 (DCLK1) is emerging as a tumor-specific stem cell marker in pancreatic cancer (PC). MicroRNA-195 (miR-195) plays an important role many types of tumors. However, the roles DCLK1 and miRNAs that directly regulate have not been elucidated. The goal this study to assess effects miR-195 on inhibiting clarify regulating mechanism miR-195-DCLK1 PC cells. Methods: expression protein tissues adjacent healthy was detected by Western blot quantitative...
Abstract Aberrant expression and activation of EGF receptor (EGFR) has been implicated in the development progression many human cancers. As such, targeted therapeutic inhibition EGFR, for example by antibodies, is a promising anticancer strategy. The overall efficacy antibody therapies results from complex interplay between affinity, valence, tumor penetration retention, signaling inhibition. To gain better insight into this relationship, we studied panel EGFR single-chain Fv (scFv)...
Tumor-associated macrophage (TAM) is a major component of tumor microenvironment (TME) and plays critical role in the progression cancer metastasis. However, TAM-mediated regulation gallbladder (GBC) has not been fully characterized. Here, we found that exosomes derived from GBC cell polarized to M2 phenotype, which then facilitated invasion migration cells. We discovered leptin was enriched cell-derived exosomes. Exosomal levels promoted GBC-SD The inhibition only attenuated polarization...
Rockfall, as a more common form of geological disaster in mountainous areas, is caused by structure, formation lithology, topography and other factors, usually appears natural slopes, artificially excavated road slope areas. According to the accumulated experience research on rolling stone movement highway recent years, order reduce adverse impact falling rocks traffic safety, people will set up protective facilities around effectively intercept stones down hillside. From practical point...
To compare the efficacy of two one-handed face mask ventilation techniques. Secondarily, we also assessed effect hand size on performance both these Eighty subjects were randomized into EO group and EC group. After receiving training, they carried out a simulation model according to order technique-EC technique or technique-EO technique, performed each for five consecutive ventilations. The primary outcomes time first chest undulation total number undulations in operations. A questionnaire...
Abstract Recent reports show that B7-H4 is highly expressed in a variety of tumor cells, functions as negative regulator T cells and then promotes progression. However, its expression role intrahepatic cholangiocarcinoma (ICC) remain unclear. In present study, ICC peritumoral tissues was determined at the level mRNA protein, bioactivity studied after modification expression. Then, mechanism related to progression induced by explored. Finally, clinical significance patients further analyzed....
Abstract Hepatocellular carcinoma (HCC) is a malignant tumor and threatens human life worldwide, whereas the etiology pathogenesis of HCC have not been fully determined. In past few years, many microRNAs (miRNAs) proved to important roles in tumorigenesis HCC. this study, we found that miR-23b was significantly upregulated tissues patients. Functional tests showed could promote cell proliferation metastasis vitro vivo . Then, mechanistic investigations suggested ST7L direct target involved...
Abstract Cervical cancer is one of the most prevalent gynecological malignancies. Although functions long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) and c-Myc in tumorigenesis have been acknowledged, roles lncRNA-PVT1 proliferation cervical are still unclear. Our study designed to demonstrate regulatory network involving cancer. Quantitative real-time PCR western blot assays were performed our research estimate expression levels proteins. CCK8 applied viability HeLa...
Intrahepatic cholangiocarcinoma (ICC) is an aggressive type of cancer, and its incidence mortality rates are increasing worldwide. Mortalin a highly conserved chaperone protein involved in multiple pathological physiological processes, including anti-apoptosis, carcinogenesis metastasis. The Bcl-2 family proteins can be divided into pro-survival pro-apoptotic members, B-cell lymphoma 2 (Bcl-2) Bcl-2-like 4 (Bax). aim the present study was to investigate association between mortalin, Bax, as...
// Sheng Dong 1 , Xiang Ma Zusen Wang Bing Han Hao Zou Zehua Wu Yunjin Zang 2 and Likun Zhuang Department of Hepatobiliary Pancreatic Surgery, The Affiliated Hospital Qingdao University, Qingdao, 266003, China Institute Transplantation Science, Correspondence to: Zhuang, email: zlk0823@163.com Zang, zangyunjin12@163.com Keywords: YY1, HDAC1, HDAC inhibitor, HCC, drug sensitivity Received: February 20, 2017 Accepted: April 05, Published: 18, ABSTRACT YY1 is a DNA-binding transcription factor...
Emerging evidence has shown that leptin, an adipocyte-derived cytokine is closely associated with obesity, play a significant role in carcinogenesis and tumorigenesis. However, its impact on gallbladder cancer (GBC) remains unclear. In this study, we firstly found leptin functional receptor OB-Rb were significantly co-expressed human GBC tissues cell lines, the content of which higher than those normal tissues. Treatment promoted proliferation, migration invasion cells, attenuated by shRNA....