A5100670482- Aortic Disease and Treatment Approaches
- Cardiac Structural Anomalies and Repair
- Cardiovascular Issues in Pregnancy
- Cardiomyopathy and Myosin Studies
- Gut microbiota and health
- Mechanical Circulatory Support Devices
- Congenital Heart Disease Studies
- Regional Economic and Spatial Analysis
- Pancreatitis Pathology and Treatment
- Cardiovascular Function and Risk Factors
- Trace Elements in Health
- Statistical Methods in Clinical Trials
- CAR-T cell therapy research
- Obstructive Sleep Apnea Research
- Ferroptosis and cancer prognosis
- Lipid metabolism and biosynthesis
- Maternal and fetal healthcare
- Health Systems, Economic Evaluations, Quality of Life
- Drug Transport and Resistance Mechanisms
- Peroxisome Proliferator-Activated Receptors
- Bladder and Urothelial Cancer Treatments
- SARS-CoV-2 detection and testing
- Aortic aneurysm repair treatments
- Urinary and Genital Oncology Studies
- Monoclonal and Polyclonal Antibodies Research
Second Affiliated Hospital of Nanjing Medical University
2017-2025
Nanjing Medical University
2025
First Affiliated Hospital of Xiamen University
2019-2025
University of Science and Technology Beijing
2024-2025
University College London
2020-2024
Royal Statistical Society
2024
ZheJiang Academy of Agricultural Sciences
2023-2024
University of Edinburgh
2024
University of Cambridge
2024
Qingdao Binhai University
2024
Abstract The duck gastrointestinal tract (GIT) harbors an abundance of microorganisms that play important role in health and production. Here, we constructed the first relatively comprehensive gut microbial gene catalog (24 million genes) 4437 metagenome‐assembled genomes using 375 GIT metagenomic samples from four different breeds across five intestinal segments under two distinct rearing conditions. We further characterized region‐specific taxonomy their assigned functions, as well...
Sudden cardiac death (SCD) is the most common mode of in childhood hypertrophic cardiomyopathy (HCM). The newly developed HCM Risk-Kids model provides clinicians with individualized estimates risk. aim this study was to externally validate a large independent, multi-centre patient cohort.
Risk-prediction models for health outcomes are used in practice as part of clinical decision-making, and it is essential that their performance be externally validated. An important aspect the design a validation study choosing an adequate sample size. In this paper, we investigate size requirements studies with binary to estimate measures predictive (C-statistic discrimination calibration slope large). We aim sufficient precision estimated measures. addition, achieve power detect difference...
Risk prediction models are routinely used to assist in clinical decision making. A small sample size for model development can compromise performance when the is applied new patients. For binary outcomes, calibration slope (CS) and mean absolute error (MAPE) two key measures on which calculations of risk have been based. CS quantifies degree overfitting while MAPE assesses accuracy individual predictions.
Abstract Aims The 12-lead electrocardiogram (ECG) is routinely performed in children with hypertrophic cardiomyopathy (HCM). An ECG risk score has been suggested as a useful tool for stratification, but this not independently validated. This aim of study was to describe the phenotype childhood HCM large, international, multi-centre cohort and investigate its role prediction arrhythmic events. Methods results Data from 356 patients mean age 10.1 years (±4.5) were collected retrospective,...
Background Inflammatory bowel disease (IBD) is a chronic inflammation of the gastrointestinal tract that co-occurs with gut microbiota dysbiosis; however, its etiology remains unclear. MicroRNA (miRNA)-microbiome interactions play an essential role in host health and disease.
It is of great significance to explore the dynamic variations in vegetation cover and identify its driving factors for restoration sustainable development regional ecological environment. Based on MODIS NDVI data from 2000 2020 contemporaneous meteorological, DEM, land use type, other data, spatiotemporal variation characteristics Greater Khingan Mountains forest-steppe ecotone were deeply analyzed, future evolution pattern was predicted by using methods Sen+Mann-Kendall trend analysis Hurst...
The dissemination of antibiotic resistance genes (ARGs) poses a substantial threat to environmental safety and human health. Herein, we present longitudinal paired study across the swine lifetime from birth market, coupled with metagenomic sequencing explore dynamics ARGs their health risk in fecal microbiome.We systematically characterized composition distribution among different growth stages. In total, 829 ARG subtypes belonging 21 types were detected, which tetracycline, aminoglycoside,...
Universities play a key role in university-industry-government interactions and are important innovation ecosystem studies. also expected to engage with industries governments contribute economic development. In the age of artificial intelligence (AI), have introduced relevant policies regarding AI-enabled universities. Previous studies not focused on provision dynamic capabilities perspective such an based policy analysis. This research work takes China as case provides framework guide how...
The prevalence of metabolic diseases has become a severe public health problem. Previously, we reported that Interleukin-22 (IL-22) was independently associated with type 2 diabetes mellitus and cardiovascular disease, could protect endothelial cells from glucose- lysophosphatidylcholine-induced injury. activity IL-22 is strongly regulated by IL-22-binding protein (IL-22BP). aim this investigation to determine the effect IL-22/IL-22BP axis on glucolipid metabolism. Serum IL-22BP expression...
We aimed to investigate whether uncomplicated type B intramural hematoma (IMHB) patients with known evolution predictors could benefit from more aggressive therapy.Retrospective analysis was performed in IMHB between January 2001 and August 2018. Cox proportional hazard models were constructed identify the specific factors associated aorta-related mortality.A total of 226 acute included. The conventional therapy group included 187 patients, other 39 received therapy. Aorta-related mortality...
Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling leading to right ventricular hypertrophy (RVH) and failure. Peroxisome proliferator-activated receptor γ (PPARγ), a member of nuclear receptors, has been proved ameliorate PAH. However, its effect on PAH-induced failure (RVF) remains unknown. Therefore, we investigated the therapeutic potential PPARγ in preventing monocrotaline (MCT)-induced RV dysfunction. The PAH model was induced MCT administration....