A5070271846- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Ocular Surface and Contact Lens
- Ophthalmology and Visual Impairment Studies
- Corneal surgery and disorders
- Neurological Disorders and Treatments
- SARS-CoV-2 detection and testing
- Healthcare Systems and Reforms
- Healthcare Systems and Public Health
- Visual perception and processing mechanisms
- Dermatology and Skin Diseases
- Acute Ischemic Stroke Management
- SARS-CoV-2 and COVID-19 Research
- Intensive Care Unit Cognitive Disorders
- Health and Wellbeing Research
- Dental Research and COVID-19
- Ginkgo biloba and Cashew Applications
- Obesity, Physical Activity, Diet
- Retinal Development and Disorders
- Family and Patient Care in Intensive Care Units
- Drug-Induced Ocular Toxicity
- Diagnosis and Treatment of Venous Diseases
- Skin Protection and Aging
Allergan (United States)
2012-2021
AbbVie (United States)
2020-2021
Allergan (Ireland)
2021
AbbVie (Ireland)
2021
University College London Hospitals NHS Foundation Trust
2020
University College London
2020
National Hospital for Neurology and Neurosurgery
2020
Ninewells Hospital
2020
Newport (United States)
2018-2019
Health Outcomes Solutions (United States)
2014
To determine whether early visual acuity response to ranibizumab in diabetic macular edema is associated with long-term outcome.Post hoc analysis of randomized controlled trial data.Pooled data from the plus prompt and deferred laser treatment arms Diabetic Retinopathy Clinical Research Network's Protocol I study were used explore relationship between (week 12) late (weeks 52-156) (mean change baseline best-corrected [CFB BCVA]; categorized improvement [<5, 5-9, or ≥10 Early Treatment Study...
To examine the utilization of bevacizumab and ranibizumab disease monitoring in patients with branch or central retinal vein occlusion (BRVO/CRVO) diabetic macular edema (DME) clinical practice.This retrospective claims analysis included newly diagnosed one more injections. Bevacizumab was assessed by year first injection: 2008-2010 cohorts (12-month follow-up), January to June 2011 cohort (6-month follow-up). The main outcome measures were mean annual numbers injections, ophthalmologist...
To determine monitoring and treatment patterns vision outcomes in real-world patients initiating anti-vascular endothelial growth factor (anti-VEGF) therapy for diabetic macular edema (DME).Retrospective interventional cohort study.Setting: Electronic medical record analysis of Geisinger Health System data.A total 110 (121 study eyes) intravitreal ranibizumab or bevacizumab DME during January 2007‒May 2012, with baseline corrected visual acuity 20/40 to 20/320, ≥1 ophthalmologist visit...
Background and Purpose— Incidence, prevalence, mortality for stroke vary by race ethnicity with higher rates blacks compared non-Hispanic whites. Little information is available regarding differences in postacute care outcomes racial ethnic groups after a stroke. Methods— A retrospective analysis was conducted of 161 692 patients from the Uniform Data System Medical Rehabilitation who received inpatient medical rehabilitation first 2002 2003. Multivariable models examined effects on length...
This post hoc analysis explores the relationship between early retinal anatomical response and long-term visual outcomes with ranibizumab in center-involved diabetic macular edema.Eyes randomized to plus prompt laser deferred treatment arms Protocol I study were categorized according their proportional reduction (<20 vs. ≥20%) central thickness (CRT) after 12 weeks. Adjusted unadjusted analyses assessed association (Week 12) (Weeks 52 156) best-corrected acuity outcomes.Of 335 eyes, 118...
Selective laser trabeculoplasty (SLT) is a common treatment option for managing glaucoma and ocular hypertension. We assessed the real-world effectiveness of SLT baseline factors associated with success in United Kingdom.Retrospective observational study de-identified electronic medical records (Medisoft Glaucoma module [Medisoft Ltd, Leeds, UK]) from 5 UK ophthalmology teaching centers.Adult patients undergoing their first recorded SLT. For bilateral (same day), analyses included 1 randomly...
Modeling of visual field and pharmacy data (Kaiser Permanente, 2001 to 2014) from open-angle/pseudoexfoliation glaucoma patients in clinical practice indicated a significant inverse association between the level medication adherence rate progression.The aim was quantify effect nonadherence topical hypotensive on glaucomatous progression practice.Retrospective analysis combined Kaiser Permanente Southern California's HealthConnect electronic health record database. Patients with diagnosis...
Abstract Background/objectives This post hoc analysis explores the relationship between residual oedema exposure after ranibizumab treatment initiation and long-term visual acuity outcome in eyes with centre-involved diabetic macular (DMO). Subjects/methods Eyes randomised to + prompt or deferred laser arms Protocol I trial observed central retinal thickness (CRT) readings at baseline ≥1 follow-up visits ( n = 367) were stratified by 1) duration (number of study CRT ≥ 250 µm during first 52...
PurposeTo assess anti-vascular endothelial growth factor (VEGF) management patterns and anatomic visual acuity (VA) outcomes among patients with neovascular age-related macular degeneration (nAMD) in United States clinical practice.DesignRetrospective observational cohort study.ParticipantsPatients (N = 30 106) initiating intravitreal anti-VEGF treatment for nAMD between October 2009 November 2016.MethodsAnalysis of longitudinal electronic health records from USRetina.Main Outcome...
To provide updated estimates of the clinical and economic burden in patients with ocular hypertension (OHT) or open-angle glaucoma (OAG) by disease severity United States to estimate incremental costs associated progression.Retrospective cohort study.Patients 1 more International Classification Diseases, 10th Revision, Clinical Modification, diagnoses for OAG OHT who are 40 years age older.Patients were identified from IQVIA's PharMetrics Plus database during index period (October 1, 2015,...
BACKGROUND AND OBJECTIVE: Diabetic macular edema (DME) is a leading cause of blindness for non-elderly adults; however, health care-associated burden data from this population lacking. The authors describe in patients with DME compared to those diabetes and no DME. PATIENTS METHODS: In retrospective, large-cohort study examines enrollment care claims (2007 2011) national database insured aged 18 63 years (mean: 51). Comorbidity utilization differences between (n = 24,326) matched controls...
BACKGROUND: New treatment alternatives have revolutionized the management of nAMD. However, there is limited evidence on clinical and economic burden nAMD in commercially insured US patients. OBJECTIVES: To examine patients with by disease status patient population to identify drivers nAMD-related costs. METHODS: Patients at least 1 International Classification Diseases, 10th Revision Clinical Modification (ICD-10-CM) diagnosis for were identified from IQVIA PharMetrics Plus database between...
To assess health care utilization and vision outcomes over 2 years in patients receiving bevacizumab treatment clinical practice for diabetic macular edema.Patients with newly diagnosed edema who received an intravitreal injection within 12 months of initial diagnosis were identified from Kaiser Permanente's 350,000 diabetes mellitus treated between 2008 2013. Snellen best-corrected visual acuity (BCVA), number injections, patient characteristics abstracted the electronic record. The main...
Background: Effective control of intraocular pressure is predicated upon patient compliance with pharmacotherapy. We compared adherence and persistence two new ocular hypotensive formulations, using real-world utilization data. Methods: This observational cohort study employed pharmacy claims data from the Source ® Lx (Wolters Kluwer Pharma Solutions) database. Patients an initial (index) prescription for topical bimatoprost 0.01% or travoprost Z (April to June 2011) no claim ophthalmic...
To study and characterize the stratum corneum (SC) of dandruff scalp using in vivo Raman spectroscopy, to how it compares with non-dandruff see effect treatment a zinc pyrithione (ZnPTO)-based anti-dandruff shampoo.The skin was measured recently developed probe. This method allows inherent molecular components SC be confocally depth, particular levels natural moisturizing factors (NMF), lipids, lactic acid, urea water.Depth-profile data for are shown first time. The has lower NMF than (0.16...
BACKGROUND AND OBJECTIVE: Patients with neovascular age-related macular degeneration (AMD) require frequent follow-up and regular anti-VEGF injections for optimal outcomes. Although studies suggest that injection frequency is suboptimal in clinical practice, monitoring this setting unclear. This study evaluates annual patterns between 2008 2011. PATIENTS METHODS: retrospective claims analysis included newly diagnosed AMD patients at least one intravitreal bevacizumab or ranibizumab (8,811...
Precis: Incremental addition of intraocular pressure–lowering topical drops is associated with shorter-lasting benefit and higher health-related costs each additional agent, suggesting a need for new treatment options to improve disease control reduce burden. Purpose: The purpose this study was evaluate intensification as driver clinical economic burden in patients receiving glaucoma medications open-angle glaucoma/ocular hypertension. Methods: This retrospective analysis administrative...
To characterize newly diagnosed primary open-angle glaucoma (OAG) patients and to describe their treatment journey in United States clinical practice according the use of topical therapy, laser trabeculoplasty, surgical procedures. Retrospective claims database study. Patients with at least 2 diagnoses OAG 7 days or more apart within 1 year, first (index) diagnosis 2010, 30 months continuous enrollment before index no medication (exception for ocular hypertension diagnosis), 48 enrollment....
Objective:To compare patient adherence and persistence with bimatoprost 0.01%, a new formulation that offers equivalent intraocular pressure-lowering efficacy to 0.03% improved tolerability, of the original formulation.
Psoriasis is a chronic, multisystem inflammatory disease, predominantly affecting the skin and joints, which present in 2−3% of world's population. Narrow band ultraviolet B (NB-UVB) Psoralen + A (PUVA) are recognised, effective and, case UVB, economical second-line treatments for psoriasis where topical therapies fail to control disease or an impracticable option due extent involvement. This article examines history phototherapy photochemotherapy looks at current used psoriasis. It...
Presbyopia is a progressive, age-related visual condition that characterized by reduced ability to focus on near/close objects, causing impacts individuals' daily function and health-related quality of life. The Impact Coping Questionnaire (PICQ) new patient-reported outcome (PRO) instrument assesses presbyopia impact use coping behaviors among presbyopic individuals.To document the associated behaviors, concept elicitation (CE) interviews were conducted with 20 participants. Results from CE...