A5031849145- Hepatitis B Virus Studies
- Enhanced Recovery After Surgery
- Mosquito-borne diseases and control
- Cardiac, Anesthesia and Surgical Outcomes
- Viral Infections and Outbreaks Research
- Viral Infections and Vectors
- Influenza Virus Research Studies
- Vaccine Coverage and Hesitancy
- SARS-CoV-2 and COVID-19 Research
- Hepatitis C virus research
- interferon and immune responses
- Dietary Effects on Health
- Patient Satisfaction in Healthcare
- Hemodynamic Monitoring and Therapy
- Intensive Care Unit Cognitive Disorders
- Adolescent and Pediatric Healthcare
- Respiratory Support and Mechanisms
- Ophthalmology and Visual Impairment Studies
- Anesthesia and Pain Management
- Diabetes Management and Research
- Retinal Diseases and Treatments
- Childhood Cancer Survivors' Quality of Life
- Bacteriophages and microbial interactions
- Botulinum Toxin and Related Neurological Disorders
- Family and Patient Care in Intensive Care Units
SUNY Upstate Medical University
2022-2025
Baruch S. Blumberg Institute
2016-2024
Trillium Health Centre
2020-2023
MD Precision (Canada)
2021-2023
AbbVie (United States)
2022-2023
Commonwealth Medical College
2023
AbbVie (Japan)
2022
Lockheed Martin (United States)
2022
McMaster University
2021
Hepatitis B Foundation
2016-2020
To determine whether early visual acuity response to ranibizumab in diabetic macular edema is associated with long-term outcome.Post hoc analysis of randomized controlled trial data.Pooled data from the plus prompt and deferred laser treatment arms Diabetic Retinopathy Clinical Research Network's Protocol I study were used explore relationship between (week 12) late (weeks 52-156) (mean change baseline best-corrected [CFB BCVA]; categorized improvement [<5, 5-9, or ≥10 Early Treatment Study...
The test-negative design is commonly used to estimate influenza and coronavirus disease 2019 (COVID-19) vaccine effectiveness (VE). In these studies, correlated COVID-19 behaviors may introduce a confounding bias where controls are included with the other vaccine-preventable acute respiratory illness (ARI). We quantified impact of this on VE estimates in studies not addressed.We simulated study populations under varying vaccination probabilities, VE, proportions ARI. Mean was calculated as...
The objective was to examine the association between mobile media device use and communication delays in 18-month-old children.A cross-sectional study conducted from September 2011 December 2015 within TARGet Kids! primary care research network. Children were included if parents reported their child's completed a validated questionnaire for delay at 18-month well child visit. Mobile measured using parent-reported survey instrument. Daily calculated as weighted average of typical weekday...
Patients with post-stroke spasticity (PSS) commonly experience pain in affected limbs, which may impact quality of life.To assess onabotulinumtoxinA for patients PSS from the BOTOX(®) Economic Spasticity Trial, a multicenter, randomized, double-blind, placebo-controlled trial.Patients (N = 273) were randomized to 22- 34-week double-blind treatment + standard care (SC) or placebo injection SC and eligible receive open-label up 52 weeks. Assessments included change baseline on 11-point numeric...
Stimulator of interferon genes (STING) is an integral ER-membrane protein that can be activated by 2'3'-cGAMP synthesized cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) upon binding double-stranded DNA. It activates (IFN) and inflammatory cytokine responses to defend against infection microorganisms. Pharmacologic activation STING has been demonstrated induce antiviral state boost antitumor immunity. We previously reported a cell-based high-throughput-screening assay...
ABSTRACT Although a highly effective vaccine is available, the number of yellow fever cases has increased over past 2 decades, which highlights pressing need for antiviral therapeutics. In high-throughput screening campaign, we identified an acetic acid benzodiazepine (BDAA) compound potently inhibits virus (YFV). Interestingly, while treatment YFV-infected cultures with μM BDAA reduced virion production by greater than logs, was not active against 21 other viruses from 14 different viral...
Hepatitis B virus (HBV) core protein is a small with 183 amino acid residues and assembles the pregenomic (pg) RNA viral DNA polymerase to form nucleocapsids. During last decades, several groups have reported HBV allosteric modulators (CpAMs) distinct chemical structures. CpAMs bind hydrophobic HAP pocket located at dimer–dimer interface induce conformational changes in subunits. While Type I CpAMs, heteroaryldihydropyrimidine (HAP) derivatives, misdirect dimers assemble noncapsid polymers,...
Flavivirus infection of cells induces massive rearrangements the endoplasmic reticulum (ER) membrane to form viral replication organelles (ROs) which segregates RNA intermediates from cytoplasmic sensors. Among other nonstructural (NS) proteins, available evidence suggests for a prominent role NS4B, an ER protein with multiple transmembrane domains, in formation ROs and evasion innate immune response. We previously reported benzodiazepine compound, BDAA, specifically inhibited yellow fever...
Abstract Galantamine, a centrally acting acetylcholinesterase inhibitor, has been shown to attenuate inflammation and insulin resistance in patients with metabolic syndrome. We investigated the effects of galantamine on glycemic control development diabetic nephropathy (DN) Lepr db/db mice. Galantamine significantly reduced food intake, body weight, blood glucose HbA1c levels. Insulin (HOMA-IR, QUICKI), HOMA-β elevations plasma inflammatory cytokine levels (TNF-α, IL-6 HMGB-1) were all...
Introduction: We hypothesized extracellular vesicles (EVs) from preconditioned human-induced pluripotent stem cell-derived mesenchymal cells (iMSCs) attenuate LPS-induced acute lung injury (ALI) and endotoxemia. Methods: iMSCs were incubated with cell stimulation cocktail (CSC) EVs isolated. iMSC-EVs characterized by size EV markers. Biodistribution of intratracheal (IT), intravenous, intraperitoneal injection in mice was examined using IVIS. Uptake tissue, alveolar macrophages, RAW264.7...
Early postoperative ambulation is associated with enhanced functional recovery, particularly in the postpartum population, but questionnaires are limited by recall bias. This observational study aims to objectively quantify after neuraxial anesthesia and analgesia for cesarean delivery vaginal delivery, respectively, using activity tracker technology. The hypothesis was that greater during first 24 h postdelivery, compared delivery.Parturients having first/second under spinal or epidural...
Results of previous studies are mixed regarding the economic implications a Roux-en-Y gastric bypass (RYGB).To assess 5-year incremental health care use and expenditures after RYGB.This population-based cohort study conducted in Ontario, Canada, used difference-in-differences approach to compare between patients who underwent publicly funded RYGB from March 1, 2010, 31, 2013, propensity score-matched control individuals did not undergo surgical bariatric procedure. The period allowed for...
Quality of recovery (QOR) instruments measure patients' ability to return baseline health status after surgery. Whether, and the extent which, postoperative ambulation contributes QOR is unclear, in part due lack valid tools clinical settings. This cohort study cesarean delivery surgical model examines accuracy reliability activity trackers quantifying early investigates correlation between QOR.A prospective 200 parturients undergoing July 2015 June 2017 was fitted with wrist-worn...
Abstract Objective To examine the impact of our new rapid refeeding protocol on patients with anorexia nervosa (AN) in Eating Disorders Program. We hypothesize that would lead to a more weight gain and shorter length stay, no effect medical complications or program completion. Method This cohort design included consecutive inpatients day hospital admitted BMI <18 kg/m 2 diagnosis AN between 2007 2020; N = 326 patients. Main outcomes measured were rate stay. Safety indicators electrolyte...
Our aim in this study was to determine whether participating an integrated stepped care model for adolescents with type 1 diabetes (T1D) would lead improvements overall quality of life (QoL), diabetes-related (DRQoL) and glycated hemoglobin (A1C) levels compared usual care.A nonrandomized, 2-group, pre/post, delayed-intervention design used study. The Mind Youth Questionnaire (MY-Q) assess QoL DRQoL. Adolescents attending the clinic using formed intervention group (n=77). These completed...
IHVR-19029 (6) is a lead endoplasmic reticulum α-glucosidases I and II inhibitor, which efficiently protected mice from lethal Ebola Marburg virus infections via injection route, but suffered low bioavailability off-target interactions with gut glucosidases when administered orally. In an effort to improve efficacious exposure levels avoid side effects, we designed synthesized ester prodrugs. Not only were the prodrugs stable in simulated gastric intestinal fluids inactive against they also...
Background: The kidney is the most common extrapulmonary organ injured in sepsis. current study examines ability of aerosolized nanochemically modified tetracycline 3 (nCMT-3), a pleiotropic anti-inflammatory agent, to attenuate acute injury (AKI) caused by intratracheal LPS. Methods: C57BL/6 mice received nCMT-3 (1 mg/kg) or saline, followed LPS (2.5 induce lung injury-induced AKI. Tissues were harvested at 24 h. effects and on AKI assessed plasma/tissue levels serum urea nitrogen,...
ABSTRACT Background: Intratracheal (IT) lipopolysaccharide (LPS) causes severe acute lung injury (ALI) and systemic inflammation. CMT-3 has pleiotropic anti-inflammatory effects including matrix metalloproteinase (MMP) inhibition, attenuation of neutrophil (PMN) activation, elastase release. CMT-3's poor water solubility limits its bioavailability when administered orally for treating ALI. We developed a nano-formulation (nCMT-3) to test the hypothesis that activities IT nCMT-3 can attenuate...
Health-care systems around the world are striving to be patient-centered, and there is growing evidence that engaging patients families in their care, as well efforts redesign services, contributes improved outcomes experiences for providers. This patient-oriented care movement includes improve quality of information communication between health-care professionals caregivers. Whiteboards have emerged a best practice hospitals promote engagement communication, yet with limited empirical...