A5061387798- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Intraocular Surgery and Lenses
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Retinal and Macular Surgery
- Ocular Diseases and Behçet’s Syndrome
- Connexins and lens biology
- Vascular Malformations Diagnosis and Treatment
- Retinal Development and Disorders
- Ocular Infections and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Corneal surgery and disorders
- Ophthalmology and Visual Impairment Studies
- Health Systems, Economic Evaluations, Quality of Life
- Systemic Lupus Erythematosus Research
- Ocular Disorders and Treatments
- Optical Imaging and Spectroscopy Techniques
- Ocular and Laser Science Research
- Cerebral Venous Sinus Thrombosis
- Ocular Surface and Contact Lens
- Medical Malpractice and Liability Issues
- Peripheral Artery Disease Management
- Intracranial Aneurysms: Treatment and Complications
- Ginkgo biloba and Cashew Applications
Roche (Switzerland)
2024-2025
Pepose Vision Institute
2014-2024
Midwest Cardiovascular Research Foundation
2024
Washington University in St. Louis
2007-2020
Retina Institute
2003-2017
Alimera Sciences (United States)
2016
University of Missouri–St. Louis
2004-2014
King George's Medical University
2000
University of Lucknow
2000
University of Washington
1998
To determine whether early visual acuity response to ranibizumab in diabetic macular edema is associated with long-term outcome.Post hoc analysis of randomized controlled trial data.Pooled data from the plus prompt and deferred laser treatment arms Diabetic Retinopathy Clinical Research Network's Protocol I study were used explore relationship between (week 12) late (weeks 52-156) (mean change baseline best-corrected [CFB BCVA]; categorized improvement [<5, 5-9, or ≥10 Early Treatment Study...
Objective: To investigate the rate and mechanism of oxygen consumption by vitreous.Methods: Oxygen was measured with a microrespirometer.Vitreous ascorbate spectrophotometrically gas chromatography-mass spectrometry.Vitreous degeneration related to concentration in samples obtained during vitrectomy.Results: Prolonged exposure or treatment oxidase eliminated vitreous.Adding restored consumption.Oxygen persisted after boiling treating vitreous chelating agents EDTA deferoxamine.In patients...
Vitrectomy, when followed by cataract surgery, increases the risk of open-angle glaucoma. This study was conducted in patients to determine whether these procedures are associated with increased exposure trabecular meshwork oxygen.Oxygen distribution recorded a fiberoptic probe undergoing surgery for cataract, glaucoma, or retinal disease. pO(2) measured beneath central cornea, mid-anterior chamber, and anterior chamber angle. In who were pseudophakic scheduled extraction, also posterior...
To examine the utilization of bevacizumab and ranibizumab disease monitoring in patients with branch or central retinal vein occlusion (BRVO/CRVO) diabetic macular edema (DME) clinical practice.This retrospective claims analysis included newly diagnosed one more injections. Bevacizumab was assessed by year first injection: 2008-2010 cohorts (12-month follow-up), January to June 2011 cohort (6-month follow-up). The main outcome measures were mean annual numbers injections, ophthalmologist...
To determine monitoring and treatment patterns vision outcomes in real-world patients initiating anti-vascular endothelial growth factor (anti-VEGF) therapy for diabetic macular edema (DME).Retrospective interventional cohort study.Setting: Electronic medical record analysis of Geisinger Health System data.A total 110 (121 study eyes) intravitreal ranibizumab or bevacizumab DME during January 2007‒May 2012, with baseline corrected visual acuity 20/40 to 20/320, ≥1 ophthalmologist visit...
To validate the performance of Notal Vision Home OCT (NVHO) system for daily self-imaging at home and characterize retinal fluid dynamics patients with neovascular age-related macular degeneration (nAMD). Prospective observational study. Fifteen participants who had least 1 eye nAMD underwent anti-VEGF treatments. The performed using NVHO 3 months. scans were uploaded to cloud, analyzed Analyzer (NOA), evaluated by human experts presence, compared in-office scans. Weekly self-scan rate,...
Excessive exposure to oxygen has been proposed be a risk factor for nuclear cataracts. For better understanding of the metabolism in eye, distribution was mapped intraocular fluids, and rate consumption by lens rabbits breathing different levels calculated.Young albino were anesthetized, intubated, exposed normoxic, hypoxic, or hyperoxic conditions. The hemoglobin saturation blood monitored with pulse oximeter, arterial measured gas analyzer. A fiberoptic optical sensor (optode) used...
Vitrectomy is associated with the rapid progression of nuclear cataracts. This study was conducted to test hypothesis that age-related liquefaction vitreous gel may also be lens opacification.Lenses from eye bank eyes were graded for nuclear, cortical, and posterior subcapsular opacities, amount liquid measured.Nuclear sclerosis (NS) grade, percent liquefaction, age all correlated highly (P < 0.0001). After adjustment made age, correlation between NS 0.37 0.0001), after 0.57 stratified into...
PurposeTo better characterize visual function decline and geographic atrophy (GA) progression secondary to age-related macular degeneration (AMD).DesignProxima A (NCT02479386)/Proxima B (NCT02399072) were global, prospective, noninterventional, observational clinical trials.ParticipantsEligible patients aged ≥50 years. Patients in Proxima had bilateral GA without choroidal neovascularization (CNV) either eye (N = 295). CNV the study CNV±GA fellow (fellow cohort, n 168) or eye, no CNV/GA...
This post hoc analysis explores the relationship between early retinal anatomical response and long-term visual outcomes with ranibizumab in center-involved diabetic macular edema.Eyes randomized to plus prompt laser deferred treatment arms Protocol I study were categorized according their proportional reduction (<20 vs. ≥20%) central thickness (CRT) after 12 weeks. Adjusted unadjusted analyses assessed association (Week 12) (Weeks 52 156) best-corrected acuity outcomes.Of 335 eyes, 118...
Neovascular age-related macular degeneration (nAMD) and diabetic edema (DME) patients treated with intravitreally injected anti-vascular endothelial growth factor (anti-VEGF) monotherapies achieve lower vision improvements compared in clinical trials. This qualitative research study aimed to better understand the real-world anti-VEGF treatment experience from nAMD DME patients', caregivers', retina specialists' perspectives.One-time, semi-structured, individual interviews were conducted...