A5064364106- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Retinal Development and Disorders
- Neuroblastoma Research and Treatments
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Cancer, Hypoxia, and Metabolism
- Retinal and Optic Conditions
- Neurobiology and Insect Physiology Research
- RNA modifications and cancer
- Molecular Communication and Nanonetworks
- Evolution and Paleontology Studies
- Vestibular and auditory disorders
- TGF-β signaling in diseases
- interferon and immune responses
- Pain Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Cancer-related gene regulation
- Memory and Neural Mechanisms
- Neurological diseases and metabolism
- Homelessness and Social Issues
- Light effects on plants
- Genetic factors in colorectal cancer
- Peroxisome Proliferator-Activated Receptors
Astellas Pharma (United States)
2025
University of North Carolina at Chapel Hill
2003-2021
NGM Biopharmaceuticals (United States)
2021
University of North Carolina Health Care
2018-2019
Roche (United States)
2016-2019
Roche (Switzerland)
2016
Novartis (Switzerland)
2016
Carl Zeiss (United States)
2016
Doheny Eye Institute
2016
Vanderbilt University
2003-2009
The phase 2 MAHALO clinical trial shows that lampalizumab reduces geographic atrophy secondary to age-related macular degeneration and implicates complement dysregulation in disease pathogenesis.
To assess visual function outcomes to 48 weeks in patients with bilateral geographic atrophy (GA) secondary age-related macular degeneration included 2 interventional clinical trials: relationship baseline lesion size, by characteristic subgroups, and correlation of GA area.The Chroma Spectri studies (ClinicalTrials.gov identifiers, NCT02247479 NCT02247531, respectively) were identically designed phase 3, double-masked, multicenter, randomized, sham injection-controlled trials that evaluated...
Abstract Lateral somatosensory areas have not been explored in detail rats, and theories on the organization of this region are based largely anatomical tracing experiments. We investigated topography by using microelectrode recordings, which were related to flattened cortical sections processed for cytochrome oxidase (CO). Two lateral identified, each containing a complete representation body. A larger, more medial formed mirror image S1 along rostrocaudal axis head corresponding previously...
Androgen receptor (AR) activity is required for prostate cancer development and progression. Thus, there a major impetus to understand the regulation of AR action. We others have previously shown that transactivation potential dependent on presence an active SWI/SNF chromatin remodeling complex. However, mechanisms underlying remained unsolved. show here BAF57 subunit, accessory component complex, critical regulator function. expressed in luminal epithelia AR-dependent prostatic...
PurposeTo better characterize visual function decline and geographic atrophy (GA) progression secondary to age-related macular degeneration (AMD).DesignProxima A (NCT02479386)/Proxima B (NCT02399072) were global, prospective, noninterventional, observational clinical trials.ParticipantsEligible patients aged ≥50 years. Patients in Proxima had bilateral GA without choroidal neovascularization (CNV) either eye (N = 295). CNV the study CNV±GA fellow (fellow cohort, n 168) or eye, no CNV/GA...
SUMMARY Naked mole-rats have a eusocial colony structure consisting of non-reproductive workers and reproductively active caste where single,dominant queen 1-3 males produce all the offspring. Well-established queens elongated bodies that characterize their caste. Worker females retain ability to transform into queens, however trigger time course for this physical transformation remain mystery. Here, we show direct link between periods pregnancy vertebral lengthening in nascent queens. Adult...
Light-inducible optogenetic systems offer precise spatiotemporal control over a myriad of biologic processes. Unfortunately, current are inherently limited by their dependence on external light sources for activation. Further, the utility laser/LED-based illumination strategies often constrained need invasive surgical procedures to deliver such devices and local heat production, photobleaching phototoxicity that compromises cell tissue viability. To overcome these limitations, we developed...
The incidence of human papilloma virus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) is increasing implicated in more than 60% all oropharyngeal carcinomas (OPSCCs). Although whole-genome, transcriptome, proteome analyses have identified altered signaling pathways HPV-induced HNSCCs, additional tools are needed to investigate the unique pathobiology OPSCC. Herein, bioinformatics HPV(+) HNSCCs revealed that tumors express full-length E6 molecular subtypes based on relative E7...
To evaluate the safety and tolerability of single multiple intravitreal injections NGM621 in patients with geographic atrophy (GA) to characterize pharmacokinetics immunogenic potential.Multicenter, open-label, single- multiple-dose phase 1 study.Fifteen enrolled at 4 sites United States. Participants had GA secondary age-related macular degeneration, lesion size ≥2.5 mm2, best-corrected visual acuity 54 letters (20/80 20/800 Snellen equivalent) study eye, no history choroidal...
Abstract Multiunit electrophysiology was combined with histological analysis of cortical sections to investigate the organization somatosensory areas in naked mole‐rat. We provide new details for primary cortex (S1) and identify modules barrels that correspond representations different body parts. In addition, location secondary (S2) are reported, evidence a third representation, likely parietal ventral area (PV), is provided discussed. S1 contained complete systematic representation...
Abstract Naked mole‐rats ( Heterocephalus glaber ) have a large cortical representation of their behaviorally important front teeth, accounting for 30% primary somatosensory cortex (SI). Here we investigated the plasticity this dental after extraction single lower tooth. The contralateral incisor normally accounts ∼15% in mole‐rats. In five right was extracted on either postnatal day 7 or 21. After 5–8 months deprived tooth zone S1 with multiunit microelectrode recordings. results revealed...
Abstract We investigated the distribution of cortical, callosal, and thalamic connections from primary somatosensory area (S1) in naked mole‐rats, concentrating on lower incisor forelimb representations. A neuronal tracer (WGA‐HRP) was injected into center each respective representation under guidance microelectrode recordings activity. The locations cells terminals were determined by aligning plots labeled with flattened cortical sections reacted for cytochrome oxidase. S1 found to have...
Mucoepidermoid carcinoma (MEC) is a life-threatening salivary gland cancer that driven primarily by transcriptional coactivator fusion composed of cyclic AMP-regulated 1 (CRTC1) and mastermind-like 2 (MAML2). The mechanisms which the chimeric CRTC1/MAML2 (C1/M2) oncoprotein rewires gene expression programs promote tumorigenesis remain poorly understood. Here, we show C1/M2 induces activation non-canonical peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) splice...
Abstract In this study, we examined the topography of projections from facial afferents to trigeminal brainstem nuclear complex (TBNC) in naked mole‐rats using neuronal tracer CTB‐HRP. Tracer injections were made a ventral dorsal sequence that included tooth pulp and dental ligament, buccal pad, vibrissae, forehead. Labeled terminals identified throughout rostrocaudal extent TBNC, including principal nucleus (Pr5), pars oralis (Sp5O), interpolaris (Sp5I), caudalis (Sp5C) spinal nucleus....
Abstract Mutations of the Smad4 gene, a member group TGF‐β signal transduction components, occur in several types cancer suggesting that its inactivation significantly affects responsiveness these tumors. To further investigate role with respect to signaling and carcinogenesis, we re‐expressed gene Smad4‐deficient cell line FaDu by microcell‐mediated chromosome transfer (MMCT) retroviral infection closely approximate physiological protein levels. The Smad4‐expressing clones were then...
To perform a retrospective post hoc subgroup analysis of the FOCUS trial to assess visual acuity outcomes and treatment benefits for patients receiving combination therapy who, at time enrollment, were naive verteporfin photodynamic (PDT) or had previously received PDT.In this 24-month data from trial, PDT-naive PDT-treated (n = 162) included. Patients randomized in 2:1 ratio receive 0.5 mg ranibizumab monthly plus PDT alone. We retrospectively identified who not prior 12- outcomes.For...
SUMMARY Mucoepidermoid carcinoma (MEC) is a life-threatening salivary gland cancer that driven primarily by the transcriptional co-activator fusion CRTC1-MAML2. The mechanisms which chimeric CRTC1-MAML2 oncoprotein rewires gene expression programs promote tumorigenesis remain poorly understood. Here, we show induces activation of non-canonical PGC-1α splice variant PGC-1α4, regulates PPARγ-dependent IGF-1 expression. This mitogenic circuitry consistent across cell lines and primary tumors....