A5081031986- Eosinophilic Esophagitis
- Eosinophilic Disorders and Syndromes
- Neuroblastoma Research and Treatments
- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
- Antifungal resistance and susceptibility
- Inflammatory Bowel Disease
- Viral-associated cancers and disorders
- Cancer, Hypoxia, and Metabolism
- Fungal Infections and Studies
- Tumors and Oncological Cases
- IL-33, ST2, and ILC Pathways
- Bladder and Urothelial Cancer Treatments
- RNA modifications and cancer
- Urologic and reproductive health conditions
- Head and Neck Anomalies
- Cancer Diagnosis and Treatment
- Teratomas and Epidermoid Cysts
- TGF-β signaling in diseases
- Soft tissue tumor case studies
- Cardiac tumors and thrombi
- Sarcoma Diagnosis and Treatment
- Microscopic Colitis
- Cytomegalovirus and herpesvirus research
- Peroxisome Proliferator-Activated Receptors
University of North Carolina at Chapel Hill
2017-2024
University of North Carolina Health Care
2018
Mortality rates associated with C. gattii infections are estimated to be between 13% and 33%, depending on an individual’s predisposition, has caused at least 39 deaths in the PNW region. There have been four other international travel cases reported patients from Europe Asia history PNW, but this report describes first North American traveler who acquired deuterogattii infection presenting within United States case of a outbreak anti-GM-CSF autoantibodies. Early accurate diagnoses important...
Abstract Background Peripheral and mucosal eosinophilia may be associated with more aggressive disease in inflammatory bowel (IBD) patients. Vedolizumab blocks T lymphocytes, eosinophil adhesion, extravasation the gastrointestinal tract. It is not known if a predictor for therapeutic efficacy of vedolizumab. Methods This was retrospective cohort study IBD patients ileal or colonic biopsies who were off steroids before starting Biopsies rereviewed by pathologists, mean density quantified....
Mucoepidermoid carcinoma (MEC) is a life-threatening salivary gland cancer that driven primarily by transcriptional coactivator fusion composed of cyclic AMP-regulated 1 (CRTC1) and mastermind-like 2 (MAML2). The mechanisms which the chimeric CRTC1/MAML2 (C1/M2) oncoprotein rewires gene expression programs promote tumorigenesis remain poorly understood. Here, we show C1/M2 induces activation non-canonical peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) splice...
Abstract Background DNA sequencing panels can simultaneously quantify human and viral tumor markers in blood. We explored changes levels of plasma following surgical resection head neck carcinoma. Methods In preresection postresection plasmas, targeted quantified variants 28 cancer genes oncogenic pathogens (human papillomavirus [HPV], Epstein‐Barr virus [EBV], Helicobacter pylori ) from 21 patients with squamous cell Results Preresection, 11 (52%) had detectable plasma, most commonly TP53...
SUMMARY Non-dysphagia symptoms, such as heartburn and dyspepsia, are poorly characterized in adults with eosinophilic esophagitis (EoE). It is unclear if treatment improves these symptoms. The aim of this paper was to assess (i) dyspepsia symptom severity adult EoE patients using validated measures; (ii) change symptoms after treatment; (iii) association endoscopic histologic features. In a prospective cohort who were not responsive proton pump inhibitor therapy, non-dysphagia assessed items...
•Angiosarcoma is a rare endothelial malignancy associated with radiation exposure.•Very rarely, angiosarcoma has been reported to arise in the uterine cervix.•We report first case of post-radiation cervix.
Abstract Mucoepidermoid carcinoma (MEC) is the most frequently occurring salivary gland (SG) malignancy. Treatments for high grade (HG) MEC are lacking due to a limited understanding of its diverse histological and clinical features. Consequently, patients with non-resectable HG often treated adjuvant radiotherapy suffer from increased rates recurrence metastasis poor 5-year survival (30-50%) as compared low (LG) (76-95%). We previously demonstrated role IGF-1 signaling, an important...
Abstract Though the primary diagnostic utility of urine cytology is in detection high grade urothelial carcinoma, malignancies other than those urinary tract origin may also be present. Direct invasion bladder by an adjacent neoplasm, metastasis from a distant primary, or inadvertent contamination during specimen collection all result nonurothelial tumor cells being present specimen. Here, we report case endometrial adenocarcinoma that was first identified voided collected for routine...
SUMMARY Mucoepidermoid carcinoma (MEC) is a life-threatening salivary gland cancer that driven primarily by the transcriptional co-activator fusion CRTC1-MAML2. The mechanisms which chimeric CRTC1-MAML2 oncoprotein rewires gene expression programs promote tumorigenesis remain poorly understood. Here, we show induces activation of non-canonical PGC-1α splice variant PGC-1α4, regulates PPARγ-dependent IGF-1 expression. This mitogenic circuitry consistent across cell lines and primary tumors....
Introduction: Patients with esophageal eosinophilia are currently categorized into two distinct entities, namely eosinophilic esophagitis (EoE) or proton pump inhibitor (PPI) responsive (PPI-REE). This categorization depends on whether the eosinophil count is more less than 15 eosinophils per high power field (15/HPF) after an 8-week trial of PPI. However, we have observed that some patients classified as having EoE can also a decline in PPI trial, but to level above arbitrary cut-off...
Abstract The Pacific Northwest (PNW), Vancouver Island, Oregon, and Washington have been the location of an ongoing Cryptococcus gattii outbreak since 1990s, there is evidence that expanding along West Coast into California. Here we report a clinical case 69-year-old, HIV-negative man from North Carolina who was diagnosed with fungal brain mass by magnetic resonance imaging (MRI) pathology. He had traveled to Seattle three years earlier Costa Rica four months prior presentation. Phenotypic...
Abstract Introduction: The presence of the t(11;19) chromosomal translocation and its CRTC1-MAML2 (C1/M2) fusion product occurs frequently in salivary mucoepidermoid carcinoma (MEC) has been correlated with a favorable prognosis. Recently, whole-exome sequencing studies found genomic alterations MEC to be infrequent, which supports role C1/M2 as an early driver event. However, when present, TP53 PIK3CA may represent alternative mutations fusion-negative cases. To better understand...