Hans Herfarth
A5079998509- Inflammatory Bowel Disease
- Microscopic Colitis
- Eosinophilic Esophagitis
- Helicobacter pylori-related gastroenterology studies
- Diverticular Disease and Complications
- Autoimmune and Inflammatory Disorders
- Celiac Disease Research and Management
- Immunodeficiency and Autoimmune Disorders
- Immune Response and Inflammation
- Colorectal Cancer Screening and Detection
- Gut microbiota and health
- Liver Diseases and Immunity
- Gastrointestinal disorders and treatments
- Autoimmune and Inflammatory Disorders Research
- IL-33, ST2, and ILC Pathways
- Colorectal Cancer Surgical Treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastrointestinal motility and disorders
- Pancreatitis Pathology and Treatment
- Mycobacterium research and diagnosis
- Immune cells in cancer
- Clostridium difficile and Clostridium perfringens research
- Immune Cell Function and Interaction
- Esophageal and GI Pathology
- Pancreatic and Hepatic Oncology Research
University of North Carolina at Chapel Hill
2016-2025
University Gastroenterology
1994-2023
Mount Sinai Hospital
2023
University of Toronto
2023
Princess Margaret Cancer Centre
2023
Cancer Research And Biostatistics
2023
Minnesota Gastroenterology
2022
Crohn's and Colitis Foundation
2021
Indiana University School of Medicine
2014-2018
Medical University of Vienna
2016
Genetic and environmental factors are important in the pathogenesis of clinical experimental chronic intestinal inflammation. We investigated influence normal luminal bacteria several groups selected bacterial strains on spontaneous gastrointestinal systemic inflammation HLA-B27 transgenic rats. Rats maintained germfree for 3-9 mo were compared with littermates conventionalized specific pathogen-free bacteria. Subsequently, rats colonized five to eight that either facultative or strictly...
Colitis-associated cancer (CAC) is a major complication of inflammatory bowel diseases. We show that components the inflammasome are protective during acute and recurring colitis CAC in dextran sulfate sodium (DSS) azoxymethane + DSS models. Mice lacking adaptor protein PYCARD (ASC) caspase-1 demonstrate increased disease outcome, morbidity, histopathology, polyp formation. The tumor burden correlated with attenuated levels IL-1β IL-18 at site. To decipher nucleotide-binding domain,...
### 1.1 Introduction Ulcerative colitis is a life long disease arising from an interaction between genetic and environmental factors, but observed predominantly in the developed countries of world. The precise aetiology unknown therefore medical therapy to cure not yet available. Within Europe there North–South gradient, incidence appears have increased Southern developing recent years.1,2 Patients may live with considerable symptom burden despite treatment (66% describe interference work...
It is well established that the intestinal microbiota plays a key role in pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC) collectively referred to as inflammatory bowel (IBD). Epidemiological studies have provided strong evidence IBD patients bear increased risk for development colorectal cancer (CRC). However, impact on colitis-associated (CAC) remains largely unknown. In this study, we new model CAC using azoxymethane (AOM)-exposed, conventionalized-Il10(-/-) mice explored...
Background & AimsWe evaluated the efficacy and safety of upadacitinib, an oral selective Janus kinase 1 inhibitor, in a randomized trial patients with Crohn's disease (CD).MethodsWe performed double-blind, phase 2 adults moderate to severe CD inadequate response or intolerance immunosuppressants tumor necrosis factor antagonists. Patients were randomly assigned (1:1:1:1:1:1) groups given placebo; 3 mg, 6 12 24 mg upadacitinib twice daily; once daily by ileocolonoscopy at weeks 16 induction...
Experimental studies have shown that luminal antigens are involved in chronic intestinal inflammatory disorders such as Crohn's disease and ulcerative colitis. Alteration of the microflora by antibiotic or probiotic therapy may induce maintain remission. The aim this randomized, placebo-controlled trial was to determine effect oral Lactobacillus GG (L. GG) medically induced Eleven patients with moderate active were enrolled receive either L. (2 × 109 CFU/day) placebo for six months. All...
Abstract Articular adipose tissue is a ubiquitous component of human joints, but its local functions are largely unknown. Because recent studies revealed several links between tissue, adipocytokines, and arthritis, we investigated the expression adipocytokine adiponectin functional role in articular synovium patients with different arthritides. In contrast to protective endocrinological vascular diseases, was found be involved key pathways inflammation matrix degradation joint. The effects...
Anemia is a frequent complication in patients with inflammatory bowel disease (IBD). The optimal route for iron supplementation to replenish stores has not been determined so far. We therefore evaluated the efficacy and safety of intravenous sucrose as compared oral sulfate treatment deficiency anemia (IDA) IBD.A randomized, prospective, open-label, multicenter study was performed 46 transferrin saturation <or=20% and/or serum ferritin concentrations <or=20 microg/L. group received single...