A5101576389- Inflammatory Bowel Disease
- Microscopic Colitis
- Adolescent and Pediatric Healthcare
- Eosinophilic Esophagitis
- Colorectal Cancer Screening and Detection
- Pregnancy and Medication Impact
- Diverticular Disease and Complications
- Nutritional Studies and Diet
- Gastrointestinal disorders and treatments
- Gastric Cancer Management and Outcomes
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Genetic factors in colorectal cancer
- Cancer, Lipids, and Metabolism
- Autoimmune and Inflammatory Disorders Research
- Nutrition and Health in Aging
- Childhood Cancer Survivors' Quality of Life
- Autoimmune and Inflammatory Disorders
- Psoriasis: Treatment and Pathogenesis
- Gastrointestinal motility and disorders
- Gastroesophageal reflux and treatments
- Diet and metabolism studies
- Celiac Disease Research and Management
- Anorectal Disease Treatments and Outcomes
- Diagnosis and treatment of tuberculosis
University of North Carolina at Chapel Hill
2011-2020
Icahn School of Medicine at Mount Sinai
2018
IQVIA (United States)
2015
University of North Carolina Health Care
2013
Indiana University School of Medicine
2008-2012
University Gastroenterology
2005
Abstract The association between obesity and colorectal neoplasia may be mediated by inflammation. Circulating levels of C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) are elevated in the obese. Adipose tissue can produce release inflammatory cytokines that potentially procarcinogenic. We examined circulating CRP, IL-6, TNF-α relation to risk factors prevalence adenomas. Plasma were quantified 873 participants (242 adenoma cases 631 controls) a...
ABSTRACT Objectives: Eosinophilic esophagitis (EoE) is becoming increasingly more common, but the prevalence of other eosinophilic gastrointestinal disorders (EGIDs) unknown. Our objective was to estimate gastritis, gastroenteritis, and colitis in United States. Methods: We used IMS Health LifeLink PharMetrics Plus Claims Database, data representative a US national commercially insured population containing medical pharmaceutical claims for >75 million individuals. restricted our sample...
OBJECTIVES: Patients with inflammatory bowel disease (IBD) may be at increased risk for infections. We aimed to determine the pneumonia in IBD and how specific medications affect this risk. METHODS: performed a retrospective cohort nested case–control study using administrative data from IMS Health Inc., LifeLink Plan Claims Database. Limitations set include lack of clinical details validate exposures outcomes. In cohort, patients were matched four individuals without IBD. Pneumonia was...
OBJECTIVES: Isotretinoin is commonly prescribed for the treatment of severe acne. Although cases inflammatory bowel disease (IBD) have been reported in isotretinoin users, a causal association remains unproven. METHODS: We performed case–control study using large insurance claims database. Incident IBD were identified and matched to three controls on basis age, gender, geographical region, health plan, length enrollment. exposure was assessed 12-month period before case ascertainment....
OBJECTIVES: Depression is prevalent in inflammatory bowel disease (IBD) patients. The impact of depression on IBD not well-studied. It unknown how providers should assess depression. METHODS: We used data from the Sinai–Helmsley Alliance for Research Excellence cohort, to methods diagnosing and effects baseline activity at follow-up. A patient health questionnaire (PHQ-8) score ≥5 was consistent with mild Relapse defined as a modified Harvey–Bradshaw Index or Simple Clinical Colitis Activity...
Maintaining a gluten-free diet (GFD) without an underlying diagnosis of celiac disease has enjoyed widespread acceptance in the Unites States. We performed cross-sectional study using GFD questionnaire 1647 patients with inflammatory bowel diseases (IBD) participating CCFA Partners longitudinal Internet-based cohort. A and non-celiac gluten sensitivity were reported by 10 (0.6%) 81 (4.9%) respondents, respectively. Three hundred fourteen (19.1%) participants having previously tried 135...
Although exercise impacts quality of life in patients with inflammatory bowel disease, little is known about its role disease activity. Among remission, we aimed to evaluate the association between and subsequent active disease. We performed a prospective study using Crohn's Colitis Foundation America Partners' internet-based cohort individuals self-reported identified participants defined as short activity index <150 or simple clinical colitis ≤2. The primary exposure was status, measured...
BackgroundThe widespread use of the Internet allows for unique research opportunities. We aimed to develop and follow an Internet-based cohort (e-cohort) patients with self-reported inflammatory bowel diseases (IBD) over time.
African American patients with colorectal cancer show higher mortality than their Caucasian counterparts. Biology might play a partial role, and prior studies suggest prevalence for microsatellite instability (MSI) among cancers from Americans, albeit MSI have improved survival over non-MSI cancers, counter to the outcome observed patients. CD8+ T cell infiltration of colon is postively correlated tumors, also related outcome. Here, we utilized 503-person, population-based cohort comprising...
Previous studies suggest that disease activity alone does not reliably predict hospital readmission among patients with inflammatory bowel diseases (IBDs). Using a national database, we aimed to further describe the burden of readmissions for IBD and identify modifiable risk factors.We performed retrospective cohort study using 2013 data from Nationwide Readmission Database (NRD). International Classification Diseases, ninth Revision, Clinical Modification (ICD-9-CM) codes, identified adult...
As traditional methods have become increasingly difficult, the Internet offers a mechanism for conducting survey research quickly and efficiently. However, validity of this depends on ability respondents to accurately report health status. We used large Internet-based inflammatory bowel disease (IBD) cohort validate self-reported IBD against physician reports.Between June 22, 2012, April 01, 2013, all participants CCFA Partners (n = 6681) were invited participate, 450 selected by random...
BackgroundFunctional health literacy is essential for the self-management of chronic diseases and preventive behaviors. Patients with cancer who have a low level may be at greater risk poor care outcomes. MethodsWe assessed using Short Test Functional Health Literacy in Adults 347 participants colorectal were nested within prospective observational study system, provider, participant characteristics influencing ResultsHaving adequate increased likelihood that stage 3/4 disease received...
There has been growing interest in social media use managing chronic illnesses. The aim of this study was to assess usage a large sample patients with inflammatory bowel disease (IBD). We performed cross-sectional within the Crohn's and Colitis Foundation's IBD Partners' internet-based cohort. used bivariate analyses compare patient characteristics by various factors associated utilization. logistic regression models determine independently using obtain IBD-related information. A total 1960...
INTRODUCTION: We conducted a cohort study on the impact of obesity disease activity and Patient-Reported Outcomes Measurement Information System (PROMIS) measures in inflammatory bowel (IBD) Partners cohort. METHODS: performed cross-sectional longitudinal within IBD Partners, an internet-based >15,000 patients living with Crohn's (CD) ulcerative colitis (UC). included adult IBD, recorded body mass index (BMI), at least 6 months follow-up, excluding BMI < 18.5 kg/m 2 . evaluated...
Restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) has become the standard surgical treatment for majority of patients inflammatory bowel disease (IBD) who require colectomy. We evaluated prevalence pouch-related symptoms among Crohn's and Colitis Foundation America Partners cohort effect on Patient-Reported Outcome Measurement Information System measures.We performed analyses nested in cohort. used bivariate to compare demographics medication use ulcerative colitis or...