A5075032970- Inflammatory Bowel Disease
- Microscopic Colitis
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Immunodeficiency and Autoimmune Disorders
- Renal Transplantation Outcomes and Treatments
- Stoma care and complications
- Autoimmune and Inflammatory Disorders
- Diverticular Disease and Complications
- Diet and metabolism studies
- Clinical Nutrition and Gastroenterology
- Transplantation: Methods and Outcomes
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Nutrition and Health in Aging
- Inflammatory mediators and NSAID effects
- Dermatology and Skin Diseases
- Diagnosis and treatment of tuberculosis
- Hidradenitis Suppurativa and Treatments
- Orthopedic Infections and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Blood Coagulation and Thrombosis Mechanisms
- Cutaneous lymphoproliferative disorders research
- Gastrointestinal motility and disorders
- Protease and Inhibitor Mechanisms
University of Michigan
2019-2024
Michigan Medicine
2020-2024
University of Missouri–Kansas City
2024
A. Alfred Taubman Health Care Center
2023
Massachusetts General Hospital
2018-2021
Harvard University
2018-2021
Harvard University Press
2020
Washington University in St. Louis
2012-2019
Rush University Medical Center
2007
University of Calgary
1998
Hidradenitis suppurativa (HS) is a debilitating chronic inflammatory skin disease characterized by abscess formation and development of multiple draining sinus tracts in the groin, axillae, perineum. Using proteomic transcriptomic approaches, we responses HS depth, revealing immune centered on IFN-γ, IL-36, TNF, with lesser contribution from IL-17A. We further identified B cells plasma cells, associated increases immunoglobulin production complement activation, as pivotal players...
OBJECTIVES: Depression is prevalent in inflammatory bowel disease (IBD) patients. The impact of depression on IBD not well-studied. It unknown how providers should assess depression. METHODS: We used data from the Sinai–Helmsley Alliance for Research Excellence cohort, to methods diagnosing and effects baseline activity at follow-up. A patient health questionnaire (PHQ-8) score ≥5 was consistent with mild Relapse defined as a modified Harvey–Bradshaw Index or Simple Clinical Colitis Activity...
The older patient group with inflammatory bowel diseases (IBD) is particularly vulnerable to consequences of disease and therapy-related side effects but little known about the best treatment options in this population.To compare safety efficacy tumor necrosis factor α antagonist (anti-TNF) or vedolizumab (VDZ) patients IBD >60 years age.This retrospective study included Crohn's (CD) ulcerative colitis (UC) initiating anti-TNF VDZ therapy ≥60 age at three sites. We examined occurrence...
Short-chain fatty acids (SCFAs), such as acetate, propionate, and butyrate, are bacterial metabolites generated via the fermentation of dietary fibers. Luminal SCFAs recognized a preferred energy substrate for colonic epithelium. As early 1980s, were observed to offer therapeutic benefit in some forms colitis.1 Since then, clinical trials have produced variable results confirming efficacy diversion colitis or inflammatory bowel disease (IBD)-associated colitis. Putative mechanistic...
Summary Background Clinical and endoscopic remission are treatment targets in ulcerative colitis (UC). The value of histologic healing altering clinical outcomes among patients with complete is not well established. Aim To quantify the association between activity relapse UC who were remission. Methods This study included from a prospective registry Histologic was quantified by senior gastrointestinal pathologist. defined as lack normalisation (Geboes score > 0) histologically active...
Acute severe ulcerative colitis [ASUC] affects one in four patients with UC. Clinical parameters perform modestly predicting the need for rescue therapy. Sarcopenia and visceral adiposity predict natural history Crohn's disease, but role of such metabolic factors on ASUC outcomes is unknown. The aim this study was to define effect sarcopenia ASUC. We studied hospitalized who underwent an abdominal CT scan during hospitalization. Quantification skeletal muscle mass performed by radiologists...
Fibrosis is the final common pathway to intestinal failure in Crohn's disease, but no medical therapies exist treat fibrosis. Activated myofibroblasts are key effector cells of fibrosis multiple organ systems, including intestine. AXL a receptor tyrosine kinase that has been implicated fibrogenic pathways involving myofibroblast activation. We aimed investigate as potential target for treatment fibrosis.To establish proof concept, we first analyzed gene expression 2 vivo models and 3 vitro...
Alpha-1 antitrypsin deficiency is caused by mutations in
We investigated the distribution and function of cannabinoid (CB) 1 receptors in submucosal plexus guinea pig ileum. CB were found on both types secretomotor neurons, colocalizing with VIP neuropeptide Y (NPY), noncholinergic cholinergic respectively. colocalized transient receptor potential vanilloid-1 paravascular nerves fibers plexus. In ganglia, these preferentially localized at periphery ganglia. denervated ileal segments, immunoreactivity neurons was not modified, but intraganglionic...
The role of nitric oxide (NO) derived from the inducible isoform NO synthase (iNOS) in epithelial transport dysfunction was studied a model colitis induced mice by intrarectal 2,4,6-trinitrobenzenesulfonic acid 30% ethanol. Expression iNOS mRNA determined RT-PCR. Electrolyte studies were conducted Ussing chambers which segments inflamed colon incubated with or without selective inhibitorl- N 6 -(1-iminoethyl)lysine (l-NIL). Seven days after induction colitis, colonic tissue exhibited...
We investigated proteinase-activated receptor-2 (PAR(2))-triggered signal transduction pathways causing increased prostaglandin E(2) (PGE(2)) formation in human lung-derived A549 epithelial cells. The PAR(2) agonist, SLIGRL-NH(2) (Ser-Leu-Ile-Gly-Arg-Leu-amide), evoked immediate cytosolic Ca(2+) mobilization and delayed (0.5-3 h) PGE(2) formation. PAR(2)-triggered was attenuated by inhibition of the following pathway enzymes: cyclooxygenases 1 2 (COX-1 COX-2, respectively), Ca(2+)-dependent...
Assessing risk of Crohn's disease (CD) recurrence following ileocolic resection (ICR) is necessary to optimize medical management and prevent long-term complications. This study aimed identify noninvasive markers that could predict postoperative activity.Inclusion criteria were a diagnosis CD, first ICR, interval colonoscopy, whole transcriptome array meeting quality control standards. Demographic clinical data obtained from the electronic record. RNA extraction human microarray performed on...
Abstract Background It is important to identify patients with inflammatory bowel disease [IBD] refractory anti-tumour necrosis factor [TNF] therapy, avoid potential adverse effects and adopt different treatment strategies. We aimed validate clinical genetic factors predict anti-TNF response in IBD. Materials Methods Mayo Clinic Washington University IBD association study cohorts were used as discovery replicate datasets, respectively. Clinical included sex, age at diagnosis, duration...
Abstract Introduction Ulcerative colitis (UC) associated with primary sclerosing cholangitis (PSC) is a rare phenotype. We aimed to assess patients UC-PSC or UC alone and describe differences in clinical phenotypic characteristics, antitumor necrosis factor (TNF) therapy, long-term outcomes. Methods This retrospective multicenter cohort study included who received diagnosis of from 1962 through 2015. evaluated factors vs assessed associations by using multivariable logistic regression...
The relative contributions of cyclooxygenase (COX)-1 and COX-2 in mediating prostaglandin (PG)-dependent chloride secretion were investigated segments mouse colon mounted Ussing-type diffusion chambers. mRNA protein constitutively expressed as shown by reverse transcription-polymerase chain reaction Western immunoblot, respectively. immunoreactivity was detected immunohistochemically cells lying subjacent to the crypt epithelial cells. In Ussing chambers, arachidonic acid caused a...
Abstract Background Inflammatory bowel disease (IBD) is associated with an increased risk of osteoporosis and bone fracture. The aims this study were to (1) confirm the association between IBD low density (2) test for shared variants across diseases. Methods cohort included patients from Michigan Genomics Initiative. Student’s t tests (continuous) chi-square (categorical) used univariate analyses. Multivariable logistic regression was performed effect on or osteopenia. Publicly available...