A5025478600- Statistical Methods in Clinical Trials
- Optimal Experimental Design Methods
- Health Systems, Economic Evaluations, Quality of Life
- CAR-T cell therapy research
- Colorectal Cancer Treatments and Studies
- Cancer Treatment and Pharmacology
- Pediatric Urology and Nephrology Studies
- Acute Myeloid Leukemia Research
- Lung Cancer Treatments and Mutations
- Advanced Causal Inference Techniques
- Urinary Tract Infections Management
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Statistical Methods and Inference
- Urological Disorders and Treatments
- Statistical Methods and Bayesian Inference
- Acute Lymphoblastic Leukemia research
- Meta-analysis and systematic reviews
- Computational Drug Discovery Methods
- Inflammatory Bowel Disease
- Cervical Cancer and HPV Research
- Cancer Genomics and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Endometrial and Cervical Cancer Treatments
University of North Carolina at Chapel Hill
2016-2025
UNC Lineberger Comprehensive Cancer Center
2013-2024
University of Oxford
2024
City Clinical Oncology Center
2016-2023
Voronezh State Medical Academy named after N.N. Burdenko
2022-2023
Institute of Genetics and Cytology of the National Academy of Sciences of Belarus
2022
Peter the Great St. Petersburg Polytechnic University
2022
Segeberger Kliniken
2021
Institute of Sociology
2021
North-Eastern Federal University
2020
Epidermal growth factor receptor (EGFR) is a targetable frequently overexpressed in basal-like breast cancer, which comprises most triple-negative cancers (TNBCs), the only subtype without established targeted therapy.In this randomized phase II trial, patients with metastatic TNBC received anti-EGFR antibody cetuximab (400 mg/m(2) load then 250 per week intravenously [IV]) alone, carboplatin (area under curve of 2, once IV) added after progression or as concomitant therapy from beginning....
Chimeric antigen receptor (CAR) T-cell therapy of B-cell malignancies has proved to be effective. We show how the same approach CAR T cells specific for CD30 (CD30.CAR-Ts) can used treat Hodgkin lymphoma (HL).
Epidemiologic and preclinical data suggest that higher intake serum levels of vitamin D calcium reduce the risk colorectal neoplasia. To further study chemopreventive potential these nutrients, we conducted a randomized, double-blind, placebo-controlled trial supplementation with D, calcium, or both for prevention adenomas.
OBJECTIVES: To identify risk factors for recurrent urinary tract infection (UTI) and renal scarring in children who have had 1 or 2 febrile symptomatic UTIs received no antimicrobial prophylaxis. METHODS: This 2-year, multisite prospective cohort study included 305 aged to 71 months with vesicoureteral reflux (VUR) receiving placebo the RIVUR (Randomized Intervention Vesicoureteral Reflux) 195 VUR observed CUTIE (Careful Urinary Tract Infection Evaluation) study. Primary exposure was...
Existing data regarding the association between delayed initiation of antimicrobial therapy and development renal scarring are inconsistent.To determine whether delay in for febrile urinary tract infections (UTIs) is associated with occurrence severity scarring.Retrospective cohort study that combined from 2 previously conducted longitudinal studies (the Randomized Intervention Children With Vesicoureteral Reflux trial Careful Urinary Tract Infection Evaluation Study). younger than 6 years a...
To compare duration of mechanical ventilation for patients randomized to receive lorazepam by intermittent bolus administration vs. continuous infusions propofol using protocols that include scheduled daily interruption sedation.A open-label trial enrolling from October 2001 March 2004.Medical intensive care units two tertiary medical centers.Adult expected require >48 hrs and who required > or =10 mg a infusion sedative achieve adequate sedation.Patients were maintain Ramsay score 2-3....
OBJECTIVE—Increasing rates of type 2 diabetes worldwide suggest that may be caused by environmental toxins. Cadmium is a widespread pollutant accumulates in the pancreas and exerts diabetogenic effects animals. To test hypothesis exposure to cadmium associated with impaired fasting glucose diabetes, we examined associations between urinary prevalence (prediabetes) Third National Health Nutrition Examination Survey (NHANES III). RESEARCH DESIGN AND METHODS—We analyzed data on 8,722 adults ≥40...
Summary. We derive the optimal allocation between two treatments in a clinical trial based on following optimality criterion: for fixed variance of test statistic, what minimizes expected number treatment failures? A sequential design is described that leads asymptotically to and compared with randomized play-the-winner rule, Neyman allocation, equal at similar power levels. find procedure generally results fewer failures than other procedures, particularly when success probabilities are smaller.
The interpretation of between-group comparisons is facilitated by the creation treatment groups that are similar to each other in baseline composition. To prevent effects from being confounded with time effects, most trials use restricted randomization force balance. An unintended consequence these restrictions they create patterns allow for prediction future allocations, and hence selection bias, especially unmasked trials. In fact, more restrictive allocation procedure, greater potential...
Little generalizable information is available on the outcomes of children diagnosed with bladder and bowel dysfunction (BBD) after a urinary tract infection (UTI). Our objectives were to describe clinical characteristics BBD examine effects patient in without vesicoureteral reflux (VUR).We combined data from 2 longitudinal studies (Randomized Intervention for Children With Vesicoureteral Reflux Careful Urinary Tract Infection Evaluation) which <6 years age first or second UTI followed years....
In kidney transplant recipients, cardiovascular disease (CVD) is the leading cause of death. The relationship function with CVD outcomes in recipients remains uncertain. We performed a post hoc analysis Folic Acid for Vascular Outcome Reduction Transplantation (FAVORIT) Trial to assess risk factors and mortality recipients. Following adjustment demographic, clinical characteristics, traditional factors, proportional hazards models were used explore association estimated GFR incident...
<h3>Objective</h3> Sentinel lymph node (SLN) mapping with indocyanine green (ICG) detected by robotic near infrared (NIR) imaging is a feasible technique. The optimal site of injection (cervical or endometrial) for endometrial cancer has yet to be determined. We prospectively evaluated SLN after cervical and injections ICG compare the detection rates patterns nodal distribution. <h3>Methods</h3> Twenty-nine subjects undergoing hysterectomy lymphadenectomy single surgeon received fluorescence...
Background and objectives The main of the Randomized Intervention for Children with Vesicoureteral Reflux (RIVUR) trial were to evaluate role antimicrobial prophylaxis in prevention recurrent urinary tract infection (UTI) renal scarring children vesicoureteral reflux (VUR). We present a comprehensive evaluation outcomes RIVUR participants. Design, setting, participants, & measurements This multicenter, randomized, placebo-controlled enrolled 607 aged 2–71 months grade 1–4 VUR diagnosed after...
Abstract Immune suppression, exhaustion, and senescence are frequently seen throughout disease progression in acute myeloid leukemia (AML). We conducted a phase II study of high-dose cytarabine followed by pembrolizumab 200 mg i.v. on day 14 to examine whether PD-1 inhibition improves clinical responses relapsed/refractory (R/R) AML. Overall responders could receive maintenance up 2 years. Among 37 patients enrolled, the overall response rate, composite complete remission (CRc) rate (primary...
Summary The objective of a Phase I trial with two agents is to find set maximum‐tolerated dose combinations that yield prespecified toxicity rate. In this article, we consider the case where several doses one agent are fixed and goal other be used in combination each one. We propose Bayesian design uses parsimonious working model for dose–toxicity relationship. show new more effective identifying than one‐dimensional designs applied at level agents.
The optimal BP level in kidney transplant recipients remains uncertain. This post hoc analysis of the Folic Acid for Vascular Outcome Reduction Transplantation (FAVORIT) trial cohort assessed associations with a pooled cardiovascular disease (CVD) outcome and all-cause mortality. In 3474 prevalent patients, mean age was 52±9 years, 63% were men, 76% white, 20% had history CVD, 40% diabetes mellitus, median time since 4.1 years (25th to 75th percentiles, 1.7-7.4); systolic 136±20 mmHg...