A5035905546- Histone Deacetylase Inhibitors Research
- Immunotherapy and Immune Responses
- Chronic Lymphocytic Leukemia Research
- Cancer Immunotherapy and Biomarkers
- Immune Cell Function and Interaction
- Protein Degradation and Inhibitors
- Epigenetics and DNA Methylation
- CAR-T cell therapy research
- Immune Response and Inflammation
- Advanced Chemical Sensor Technologies
- Peptidase Inhibition and Analysis
- Sensory Analysis and Statistical Methods
- Lymphoma Diagnosis and Treatment
- Immune cells in cancer
- Meat and Animal Product Quality
- Monoclonal and Polyclonal Antibodies Research
- Horticultural and Viticultural Research
- Chronic Myeloid Leukemia Treatments
- Ubiquitin and proteasome pathways
- Phytochemicals and Antioxidant Activities
- Acute Myeloid Leukemia Research
- Fermentation and Sensory Analysis
- Analytical Chemistry and Chromatography
- Virus-based gene therapy research
- Immunodeficiency and Autoimmune Disorders
Moffitt Cancer Center
2016-2025
University of South Florida
2022
University of Minnesota
2012
Theodore Roosevelt High School
2003
Tampa Bay Research Institute
2003
University of Georgia
1976-1993
Philippine Rice Research Institute
1989
NOAA National Marine Fisheries Service
1988
Georgia College & State University
1988
University of Helsinki
1987
The anti-cancer effects of metformin, the most widely used drug for type 2 diabetes, alone or in combination with ionizing radiation were studied MCF-7 human breast cancer cells and FSaII mouse fibrosarcoma cells. Clinically achievable concentrations metformin caused significant clonogenic death Importantly, was preferentially cytotoxic to stem relative non-cancer Metformin increased radiosensitivity vitro, significantly enhanced radiation-induced growth delay tumors (s.c.) legs C3H mice....
The immune checkpoint receptor PD-1 on T follicular helper (Tfh) cells promotes Tfh:B cell interactions and appropriate positioning within tissues. Here, we examined the impact of regulation expression by genomic organizer SATB1 Tfh differentiation. Vaccination CD4CreSatb1f/f mice enriched for antigen-specific cells, TGF-β-mediated repression enhanced differentiation human cells. Mechanistically, high Icos in Satb1-/- CD4+ promoted preventing regulatory skewing resulted increased...
Despite repeated associations between T cell infiltration and outcome, human ovarian cancer remains poorly responsive to immunotherapy. We report that the hallmarks of tumor recognition in cancer-infiltrating cells are primarily restricted tissue-resident memory (TRM) cells. Single-cell RNA/TCR/ATAC sequencing 83,454 CD3
Histone deacetylases (HDACs), originally described as histone modifiers, have more recently been demonstrated to target a variety of other proteins unrelated the chromatin environment. In this context, our present work demonstrates that pharmacological or genetic abrogation HDAC6 in primary melanoma samples and cell lines, down‐regulates expression PD‐L1, an important co‐stimulatory molecule expressed cancer cells, which activates inhibitory regulatory pathway PD‐1 T‐cells. Our data suggests...
Histone deacetylases (HDACs) are involved in diverse cellular regulatory mechanisms including non-canonical functions outside the chromatin environment. Several publications have demonstrated that selective HDAC inhibitors (HDACi) can influence tumor immunogenicity and functional activity of specific immune cells. In particular, inhibition HDAC6 has been reported to decrease growth several malignancies. However, there is still no clarity about components mediating this effect. study, we...
The median survival for metastatic melanoma is in the realm of 8–16 months and there are few therapies that offer significant improvement overall survival. One recent advances cancer treatment focuses on epigenetic modifiers to alter survivability immunogenicity cells. Our group others have previously demonstrated pan‐HDAC inhibitors induce apoptosis, cell cycle arrest changes Here we interrogated specific HDACs which may be responsible this effect. We found both genetic abrogation...
SUMMARY— Stepwise discriminant analysis for classifying food samples (known independently to differ in flavor) is illustrated by computer of gas chromatograms from roasted coffee and potato chips. Four lots prepared so as flavor were scored organoleptically, steam distilled, the distillate examined chromatographically. By calculating all possible ratios among peak heights subjecting these analysis, could be classified into four categories chromatographic data. The procedure was set select...
The in-clinic phosphatidylinositol 3-kinase (PI3K) inhibitors idelalisib (CAL-101) and duvelisib (IPI-145) have demonstrated high rates of response progression-free survival in clinical trials B-cell malignancies, such as chronic lymphocytic leukemia (CLL). However, a incidence adverse events has led to frequent discontinuations, limiting the development these inhibitors. By contrast, dual PI3Kδ/casein kinase-1-ε (CK1ε) inhibitor umbralisib (TGR-1202) also shows but an improved safety...
Recent studies suggest that B cells could play an important role in the tumor microenvironment. However, of humoral responses endometrial cancer remains insufficiently investigated. Using a cohort 107 patients with different histological subtypes carcinoma, we evaluated coordinated and cellular adaptive immune cancer. Concomitant accumulation T, B, plasma at beds predicted better survival. only B-cell markers corresponded prolonged survival specifically high-grade endometrioid type serous...
Dimeric IgA (dIgA) can move through cells via the IgA/IgM polymeric immunoglobulin receptor (PIGR), which is expressed mainly on mucosal epithelia. Here, we studied ability of dIgA to target commonly mutated cytoplasmic oncodrivers. Mutation-specific dIgA, but not IgG, neutralized KRAS
ABSTRACT Two different panels were trained to evaluate the character of four aromatic and two nonaromatic rices. The judges used terms with which they familiar describe odor rice: pandan for orientals popcorn nonorientals. rice volatiles separated by a gas chromatograph equipped packed column sniffing port. peaks possessing principle identified GC‐MS correlated desirable aroma terms. 2‐Acetyl‐l‐pyrroline showed highly significant positive correlations descriptive terms; hexanol negative correlations.
SUMMARY— The flavor threshold concentrations were determined for 23 compounds composing an artificial peach beverage base. levels ranged from 52 ppm to 0.4 ppb. values used in sub‐threshold, additive and concentration trials. Sub‐threshold sub‐threshold effects resulted only a few of the combinations tried. Change one compound mixture six was not readily detectable organoleptically. difference could be detected gas chromatographically, but if mixtures extracted with pentane concentrated. By...
Peptide vaccines are capable of eliciting immune responses targeting tumor-associated antigens such as the Wilms' Tumor 1 (WT1) antigen, often overexpressed in myeloid malignancies. Here, we assessed safety, tolerability, and immunogenicity a polyvalent WT1 peptide vaccine. Individuals with WT1-positive acute leukemia (AML) first (CR1) or second (CR2) remission higher-risk myelodysplastic syndrome (MDS) following at least prior line therapy were vaccinated mixture peptides derived from...
Abstract Epigenetic changes in chromatin structure have been recently associated with the deregulated expression of critical genes normal and malignant processes. HDAC11, newest member HDAC family enzymes, functions as a negative regulator IL-10 APCs, previously described by our lab. However, at present time, its role other hematopoietic cells, specifically neutrophils, has not fully explored. In this report, for first we novel physiologic HDAC11 multifaceted neutrophils. Thus far, able to...
Abstract Although chimeric antigen receptor (CAR)-expressing T cells have proven success in hematologic malignancies, their effectiveness solid tumors has been largely unsuccessful thus far. We found that some olfactory receptors are expressed a variety of different histologic subtypes, with limited pattern expression normal tissues. Quantification OR2H1 by qRT-PCR and Western blot analysis 17 tissues, 82 ovarian cancers various histologies, eight non–small cell lung (NSCLCs), breast...
Journal Article Comparison of odors directly and through profiling Get access A. Dravnieks, Dravnieks IIT Research InstituteChicago, IL 60616 Search for other works by this author on: Oxford Academic PubMed Google Scholar F.C. Bock, Bock J.J. Powers, Powers University GeorgiaAthens, GA 30602 M. Tibbetts, Tibbetts Pepsico, Inc.Long Island City, NY 11101 Ford Olin Corp.Brandenburg, KY 40108 Chemical Senses, Volume 3, Issue 2, July 1978, Pages 191–225, https://doi.org/10.1093/chemse/3.2.191...
THE loss to the commercial broiler industry due bruising accounts for many millions of dollars annually. If age these bruises could be easily ascertained, a means would then available assigning responsibility losses involved and possibly developing incentives minimizing such losses. At present, determination poultry is based on gross observations characteristic progression color alterations in damaged area. These changes have been shown vary considerably physical physiological factors (Hamdy...