A5062152897- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Virus-based gene therapy research
- T-cell and B-cell Immunology
- Galectins and Cancer Biology
- Tryptophan and brain disorders
- Viral Infectious Diseases and Gene Expression in Insects
- Glycosylation and Glycoproteins Research
- Fungal Infections and Studies
- Viral-associated cancers and disorders
- Single-cell and spatial transcriptomics
- Lymphoma Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- Cutaneous lymphoproliferative disorders research
- Reproductive System and Pregnancy
- Ovarian cancer diagnosis and treatment
Moffitt Cancer Center
2020-2023
The immune checkpoint receptor PD-1 on T follicular helper (Tfh) cells promotes Tfh:B cell interactions and appropriate positioning within tissues. Here, we examined the impact of regulation expression by genomic organizer SATB1 Tfh differentiation. Vaccination CD4CreSatb1f/f mice enriched for antigen-specific cells, TGF-β-mediated repression enhanced differentiation human cells. Mechanistically, high Icos in Satb1-/- CD4+ promoted preventing regulatory skewing resulted increased...
Despite repeated associations between T cell infiltration and outcome, human ovarian cancer remains poorly responsive to immunotherapy. We report that the hallmarks of tumor recognition in cancer-infiltrating cells are primarily restricted tissue-resident memory (TRM) cells. Single-cell RNA/TCR/ATAC sequencing 83,454 CD3
Recent studies suggest that B cells could play an important role in the tumor microenvironment. However, of humoral responses endometrial cancer remains insufficiently investigated. Using a cohort 107 patients with different histological subtypes carcinoma, we evaluated coordinated and cellular adaptive immune cancer. Concomitant accumulation T, B, plasma at beds predicted better survival. only B-cell markers corresponded prolonged survival specifically high-grade endometrioid type serous...
Dimeric IgA (dIgA) can move through cells via the IgA/IgM polymeric immunoglobulin receptor (PIGR), which is expressed mainly on mucosal epithelia. Here, we studied ability of dIgA to target commonly mutated cytoplasmic oncodrivers. Mutation-specific dIgA, but not IgG, neutralized KRAS
Abstract Although chimeric antigen receptor (CAR)-expressing T cells have proven success in hematologic malignancies, their effectiveness solid tumors has been largely unsuccessful thus far. We found that some olfactory receptors are expressed a variety of different histologic subtypes, with limited pattern expression normal tissues. Quantification OR2H1 by qRT-PCR and Western blot analysis 17 tissues, 82 ovarian cancers various histologies, eight non–small cell lung (NSCLCs), breast...
Abstract The pathogenesis of cutaneous T-cell lymphoma (CTCL) remains unclear. Using single-cell RNA or receptor (TCR) sequencing 32 619 CD3+CD4+ and CD26+/CD7+ 29 932 CD26−/CD7− lymphocytes from the peripheral blood 7 patients with CTCL, coupled to ATAC-sequencing 26,411 33 841 lymphocytes, we show that tumor cells in Sézary syndrome mycosis fungoides (MF) exhibit different phenotypes trajectories differentiation. When compared MF, narrower repertoires TCRs clonal enrichment. Surprisingly,...
Cutaneous T cell lymphoma (CTCL) has a poorly understood etiology and no known cure. Using conditional knockout mice, we found that ablation of the genomic organizer special AT-rich sequence-binding protein 1 (Satb1) caused malignant transformation mature, skin-homing, Notch-activated CD4+ CD8+ cells into progressively fatal lymphoma. Mechanistically, Satb1 restrained Stat5 phosphorylation expression skin-homing chemokine receptors in mature cells. Notably, methyltransferase-dependent...
To demonstrate that shared antibody responses in endometriosis and endometriosis-associated ovarian cancer spontaneously antagonize malignant progression can be leveraged to develop future immunotherapies.
Supplementary Data from Olfactory Receptor OR2H1 Is an Effective Target for CAR T Cells in Human Epithelial Tumors
Abstract Chimeric antigen receptor (CAR) T cells have been successful for hematological malignancies, but so far showed limited efficiency against solid tumors. Olfactory receptors are expressed in a variety of epithelial cancers, with expression healthy tissues. We quantified olfactory OR2H1 ovarian cancer, non-small cell lung cancer (NSCLC), breast and many normal tissues, we found is multiple tumors to testis among human CAR targeting OR2H1-extracellular domain were generated,...
<div>Abstract<p>Recent studies suggest that B cells could play an important role in the tumor microenvironment. However, of humoral responses endometrial cancer remains insufficiently investigated. Using a cohort 107 patients with different histological subtypes carcinoma, we evaluated coordinated and cellular adaptive immune cancer. Concomitant accumulation T, B, plasma at beds predicted better survival. only B-cell markers corresponded prolonged survival specifically high-grade...
Supplementary Figure from IgA-Dominated Humoral Immune Responses Govern Patients' Outcome in Endometrial Cancer
Supplementary Figure from IgA-Dominated Humoral Immune Responses Govern Patients' Outcome in Endometrial Cancer
Supplementary Figure from IgA-Dominated Humoral Immune Responses Govern Patients' Outcome in Endometrial Cancer
Supplementary Figure from IgA-Dominated Humoral Immune Responses Govern Patients' Outcome in Endometrial Cancer
<div>Abstract<p>Recent studies suggest that B cells could play an important role in the tumor microenvironment. However, of humoral responses endometrial cancer remains insufficiently investigated. Using a cohort 107 patients with different histological subtypes carcinoma, we evaluated coordinated and cellular adaptive immune cancer. Concomitant accumulation T, B, plasma at beds predicted better survival. only B-cell markers corresponded prolonged survival specifically high-grade...
Supplementary Figure from IgA-Dominated Humoral Immune Responses Govern Patients' Outcome in Endometrial Cancer
Supplementary Figure from IgA-Dominated Humoral Immune Responses Govern Patients' Outcome in Endometrial Cancer
Supplementary Figure from IgA-Dominated Humoral Immune Responses Govern Patients' Outcome in Endometrial Cancer
Supplementary Figure from IgA-Dominated Humoral Immune Responses Govern Patients' Outcome in Endometrial Cancer
Supplementary Figure from IgA-Dominated Humoral Immune Responses Govern Patients' Outcome in Endometrial Cancer
Supplementary Figure from IgA-Dominated Humoral Immune Responses Govern Patients' Outcome in Endometrial Cancer
Supplementary Figure from IgA-Dominated Humoral Immune Responses Govern Patients' Outcome in Endometrial Cancer
Supplementary Figure from IgA-Dominated Humoral Immune Responses Govern Patients' Outcome in Endometrial Cancer