A5028495762- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Digestive system and related health
- Epigenetics and DNA Methylation
- Immunotherapy and Immune Responses
- Alzheimer's disease research and treatments
- Cancer Immunotherapy and Biomarkers
- RNA and protein synthesis mechanisms
- Colorectal Cancer Screening and Detection
- Genomics and Chromatin Dynamics
- Supramolecular Self-Assembly in Materials
- DNA and Nucleic Acid Chemistry
- Proteins in Food Systems
- Cancer Research and Treatments
- Computational Drug Discovery Methods
- Adipokines, Inflammation, and Metabolic Diseases
- Advanced Glycation End Products research
- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- Cardiovascular Disease and Adiposity
- Fungal Infections and Studies
- Immune cells in cancer
- Inflammasome and immune disorders
- Atherosclerosis and Cardiovascular Diseases
- Cutaneous lymphoproliferative disorders research
Moffitt Cancer Center
2023-2024
University of Chicago
2023-2024
Emory University
2021-2022
University of South Florida
2019-2020
Abstract Purpose: Immune checkpoint blockade holds promise for treating bacillus Calmette-Guerin (BCG)-unresponsive non–muscle-invasive bladder cancer (NMIBC). In this phase II study, we investigated the safety and efficacy of durvalumab, a human IgG1 monoclonal antibody, against BCG-unresponsive carcinoma in situ (CIS). Patients Methods: with CIS-containing NMIBC received durvalumab IV at 1,500 mg every 4 weeks up to 12 months. The primary endpoint was complete response (CR) rate month 6,...
Abstract Amyloid‐β peptides (Aβ) assemble into both rigid amyloid fibrils and metastable oligomers termed AβO or protofibrils. In Alzheimer's disease, Aβ constitute the core of senile plaques, but protofibrils may represent main toxic species. accumulate at exterior yet protofibril–fibril interplay is not well understood. Applying chemical kinetics atomic force microscopy to assembly lysozyme, are observed bind lateral surfaces fibrils. When utilizing variants with different critical...
Cancer immunotherapy is moving toward combination regimens with agents of complementary mechanisms action to achieve more frequent and robust efficacy. However, compared single-agent therapies, immunotherapies are associated increased overall toxicity because the very same also work in concert enhance systemic inflammation promote off-tumor toxicity. Therefore, rational design that improved antitumor control without exacerbated a main objective immunotherapy. Here, we show engineered, tumor...
Abstract The pathogenesis of cutaneous T-cell lymphoma (CTCL) remains unclear. Using single-cell RNA or receptor (TCR) sequencing 32 619 CD3+CD4+ and CD26+/CD7+ 29 932 CD26−/CD7− lymphocytes from the peripheral blood 7 patients with CTCL, coupled to ATAC-sequencing 26,411 33 841 lymphocytes, we show that tumor cells in Sézary syndrome mycosis fungoides (MF) exhibit different phenotypes trajectories differentiation. When compared MF, narrower repertoires TCRs clonal enrichment. Surprisingly,...
Assembly of amyloid fibrils and small globular oligomers is associated with a significant number human disorders that include Alzheimer's disease, senile systemic amyloidosis, type II diabetes. Recent findings implicate as the dominant aggregate species mediating toxic effects in these disorders. However, validation this hypothesis has been hampered by dearth experimental techniques to detect, quantify, discriminate oligomeric intermediates from late-stage fibrils, vitro vivo. We have shown...
Background The use of immune checkpoint inhibitors (CPIs) has become a dominant regimen in modern cancer therapy, however resistance induced by tumor-associated macrophages (TAMs) with suppressive and evasion properties limits responses. Therefore, the rational design modulators that can control TAMs polarize them, as well dendritic cells (DCs), toward more proinflammatory phenotype is principal objective immunotherapy. Methods Here, using protein engineering approach to enhance cytokine...
ABSTRACT Atherosclerosis is a chronic inflammatory disease associated with the accumulation of low-density lipoprotein (LDL) in arterial walls. Higher levels anti-inflammatory cytokine IL-10 serum are correlated reduced plaque burden. However, therapies have not translated well to clinic, partially due their rapid clearance and pleiotropic nature. Here, we engineered overcome these challenges by hitchhiking on LDL atherosclerotic plaques. Specifically, constructed fusion proteins which one...
<p>12-CK Score from RNA Sequencing</p>
<p>Study Representativeness Table</p>
<p>Study Representativeness Table</p>
<div>Abstract<p>Purpose: Immune checkpoint blockade holds promise for treating BCG-unresponsive non-muscle invasive bladder cancer. In this phase II study, we investigated the safety and efficacy of durvalumab, a human IgG1 monoclonal antibody, against CIS. Patients Methods: with CIS containing cancer received durvalumab IV at 1500 mg every 4 weeks up to 12 months. The primary endpoint was complete response rate month 6, defined by negative cystoscopy, urine cytology absence...
<p>12-CK Score from RNA Sequencing</p>
Abstract Butyrate is a gut microbiota derived short chain fatty acid with pleiotropic positive effects on inflammation and metabolism. In atherosclerosis, sodium butyrate has been shown to significantly reduce atherosclerotic lesions, rectify routine metabolic parameters such as LDL-C in the serum, systemic inflammation. However, its foul odor, low absorption, fast metabolism limit therapeutic effectiveness. We engineered derivate of attached amino serine (SerBut) mask taste odor co-opt...
Abstract Amyloid‐β peptides (Aβ) assemble into both rigid amyloid fibrils and metastable oligomers termed AβO or protofibrils. In Alzheimer's disease, Aβ constitute the core of senile plaques, but protofibrils may represent main toxic species. accumulate at exterior yet protofibril–fibril interplay is not well understood. Applying chemical kinetics atomic force microscopy to assembly lysozyme, are observed bind lateral surfaces fibrils. When utilizing variants with different critical...
DNA can act as a scaffold for the cooperative binding of protein oligomers. For example, phage 186 CI repressor forms wheel seven dimers wrapped in with specific sites, while λ bind to two well‐separated sets operators, forming loop. Atomic force microscopy was used measure transcription elongation by Escherichia coli RNA polymerase (RNAP) through these complexes. CI, or bound along unlooped negligibly interfered RNAP. Wrapped and looped topologies induced scaffolded, cooperatively oligomers...
You have accessJournal of UrologyCME1 Apr 2023MP69-03 EXAMING THE LANDSCAPE OF CONCURRENT UPPER TRACT AND LOWER UROTHELIAL CARCINOMA USING SPATIAL TRANSCRIPTOMIC ANALYSIS Shreyas Naidu, Facundo Davaro, Xuefeng Wang, Elizabeth Heather Huelster, Kyle Rose, Gustavo Borjas, Aram Vosoughi, and Roger Li NaiduShreyas Naidu More articles by this author , DavaroFacundo Davaro WangXuefeng Wang DavaroElizabeth HuelsterHeather Huelster RoseKyle Rose BorjasGustavo Borjas VosoughiAram Vosoughi LiRoger...
<div>AbstractPurpose:<p>Immune checkpoint blockade holds promise for treating bacillus Calmette-Guerin (BCG)-unresponsive non–muscle-invasive bladder cancer (NMIBC). In this phase II study, we investigated the safety and efficacy of durvalumab, a human IgG1 monoclonal antibody, against BCG-unresponsive carcinoma <i>in situ</i> (CIS).</p>Patients Methods:<p>Patients with CIS-containing NMIBC received durvalumab IV at 1,500 mg every 4 weeks up to 12 months....
<div>Abstract<p>Purpose: Immune checkpoint blockade holds promise for treating BCG-unresponsive non-muscle invasive bladder cancer. In this phase II study, we investigated the safety and efficacy of durvalumab, a human IgG1 monoclonal antibody, against CIS. Patients Methods: with CIS containing cancer received durvalumab IV at 1500 mg every 4 weeks up to 12 months. The primary endpoint was complete response rate month 6, defined by negative cystoscopy, urine cytology absence...
<p>Study Representativeness Table</p>
<p>12-CK Score from RNA Sequencing</p>
<p>Study Representativeness Table</p>
<p>12-CK Score from RNA Sequencing</p>
Abstract DNA can act as a scaffold for the cooperative binding of protein oligomers. For example, phage 186 CI repressor forms wheel seven dimers wrapped in carrying specific sites, while λ binds units to two well-separated sets operators, forming loop. Atomic force microscopy was used measure transcription elongation by E. coli RNA polymerase through these complexes. or bound along unlooped negligibly interfered with RNAP. More complex topologies induced scaffolded, cooperatively oligomers...