A5020416014- Chronic Lymphocytic Leukemia Research
- CAR-T cell therapy research
- Pancreatic function and diabetes
- Immunodeficiency and Autoimmune Disorders
- Rabies epidemiology and control
- PI3K/AKT/mTOR signaling in cancer
- Animal Disease Management and Epidemiology
- Immune Cell Function and Interaction
- Phagocytosis and Immune Regulation
- Vector-Borne Animal Diseases
- Chronic Myeloid Leukemia Treatments
- Single-cell and spatial transcriptomics
- Viral Infections and Vectors
- Atherosclerosis and Cardiovascular Diseases
- Immunotherapy and Immune Responses
- Galectins and Cancer Biology
- Histone Deacetylase Inhibitors Research
- Signaling Pathways in Disease
- Poxvirus research and outbreaks
- Lymphoma Diagnosis and Treatment
- Virology and Viral Diseases
- Microbial infections and disease research
- T-cell and B-cell Immunology
- Viral Infections and Immunology Research
Moffitt Cancer Center
2019-2025
University of South Florida
2020-2024
Mercer University Health Sciences Center
2019-2020
Veterinary Serum and Vaccine Research Institute
2014-2015
The in-clinic phosphatidylinositol 3-kinase (PI3K) inhibitors idelalisib (CAL-101) and duvelisib (IPI-145) have demonstrated high rates of response progression-free survival in clinical trials B-cell malignancies, such as chronic lymphocytic leukemia (CLL). However, a incidence adverse events has led to frequent discontinuations, limiting the development these inhibitors. By contrast, dual PI3Kδ/casein kinase-1-ε (CK1ε) inhibitor umbralisib (TGR-1202) also shows but an improved safety...
Aim: A comparison study was conducted to explore the best internationally available adjuvant that could be used in production of a highly potent foot and mouth disease (FMD) vaccine, stimulate strong immune response possibly give greater protection against FMD.Materials Methods: Four experimental batches trivalent FMD vaccine were prepared with different oil adjuvants which included Montanide ISA 201, 206, 61 50.Results: The results indicated vaccines emulsified using 201 206 elicited...
Development of chronic lymphocytic leukemia (CLL) is associated with severe immune dysfunction. T-cell exhaustion, checkpoint upregulation, and increase regulatory T cells contribute to an immunosuppressive tumor microenvironment. As a result, CLL patients are severely susceptible infectious complications that morbidity mortality. B-cell survival highly dependent upon interaction the supportive It has been postulated reversal dysfunction in may be beneficial reduce burden. Previous studies...
Aim:The aim of this study is to provide adequate protection ewes and their lambs against Foot Mouth disease (FMD) Rift Valley Fever (RVF). Materials Methods:A combined inactivated FMD RVF oil vaccine was prepared successfully.Such found be free from foreign contaminants, safe potent as determined by quality control tests such challenge percentage for mice ED 50 RVF.Vaccination pregnant with the determination antibody level via serum neutralization test (SNT) Enzyme Linked immune sorbent...
Although preclinical investigations have shown notable efficacy in solid tumor models utilizing vitro-differentiated Th17 cells for adoptive cell therapy (ACT), the potential benefits of this strategy enhancing ACT hematological malignancies, such as chronic lymphocytic leukemia (CLL), remain unexplored. CLL is a B-cell malignancy with clinical challenge increased resistance to targeted therapies. T-cell therapies, including chimeric antigen receptor (CAR) T cells, demonstrated limited...
Abstract Chronic lymphocytic leukemia (CLL) is the most predominant affecting elderly population in western countries. T-cell dysfunction a CLL hallmark contributing to low success rates of adoptive cell therapy patients. Generally, exhausted states tumor infiltrating lymphocytes are associated with defects metabolic and mitochondrial adaptation, preventing normal cytotoxic functions. A handful recent reports have demonstrated patients’ T-cells. Nevertheless, field still lacking sufficient...
Abstract It is well established that CD4+FOXP3+ T regulatory cells (Tregs) contribute to dampening anti-tumor responses. Despite our improved understanding of their role in cancer, there remains a knowledge gap with respect the clonal composition and heterogeneity tumor-infiltrating Tregs solid cancers. We addressed this outstanding issue by conducting comprehensive phenotypic profiling present lung adenocarcinomas genetically engineered mouse model non-small cell cancer (NSCLC) as those...
Abstract Phosphatidylinositol-3 kinase (PI3K) delta signaling is essential for CLL B cell survival and proliferation. Several PI3K inhibitors are approved treatment of CLL, but inhibitor-induced alterations in T function have been correlated with immune-related adverse events (irAEs). Zandelisib a novel selective PI3Kδ inhibitor clinical development an intermittent dosing schedule malignancies. Here, we investigated the dynamic immunomodulatory properties zandelisib alone or combination BTK...