A5034696769- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Stress Responses and Cortisol
- Renin-Angiotensin System Studies
- Electrospun Nanofibers in Biomedical Applications
- Aerosol Filtration and Electrostatic Precipitation
- Neuroendocrine regulation and behavior
- Advanced Sensor and Energy Harvesting Materials
- Hormonal Regulation and Hypertension
- Apelin-related biomedical research
- Sodium Intake and Health
- Genomics and Phylogenetic Studies
- Adipose Tissue and Metabolism
- Immunotherapy and Immune Responses
- Eicosanoids and Hypertension Pharmacology
- Regulation of Appetite and Obesity
- Civil and Geotechnical Engineering Research
- Adipokines, Inflammation, and Metabolic Diseases
- Cell Adhesion Molecules Research
- Wheat and Barley Genetics and Pathology
- Tryptophan and brain disorders
- Geoscience and Mining Technology
- Angiogenesis and VEGF in Cancer
- Gas Sensing Nanomaterials and Sensors
- Surface Modification and Superhydrophobicity
- Protease and Inhibitor Mechanisms
Xi'an Jiaotong University
2015-2025
XinHua Hospital
2010-2025
Northwest University
2025
Sichuan University
2006-2024
Guangzhou University of Chinese Medicine
2021-2024
Guangdong Academy of Medical Sciences
2024
Chengdu Medical College
2007-2023
Northwest Normal University
2023
Analysis and Testing Centre
2023
Tianjin University of Science and Technology
2021-2022
Hepatitis B virus (HBV) core protein assembles viral pre-genomic (pg) RNA and DNA polymerase into nucleocapsids for reverse transcriptional replication to take place. Several chemotypes of small molecules, including heteroaryldihydropyrimidines (HAPs) sulfamoylbenzamides (SBAs), have been discovered allosterically modulate structure consequentially alter the kinetics pathway assembly, resulting in formation irregularly-shaped aggregates or "empty" capsids devoid polymerase. Interestingly,...
Exercise (Ex) has long been recognized to produce beneficial effects on hypertension (HTN). This coupled with evidence of gut dysbiosis and an impaired gut-brain axis led us hypothesize that reshaping microbiota improvement in would, part, be associated influence exercise. Male spontaneously hypertensive rats (SHR) Wistar Kyoto (WKY) were randomized into sedentary, trained, detrained groups. Trained underwent moderate-intensity exercise for 12 weeks, whereas, groups 8 weeks followed by 4...
Adiponectin, the adipose-derived hormone, plays an important role in suppression of metabolic disorders that can result type 2 diabetes, obesity, and atherosclerosis. It has been shown up-regulation adiponectin or receptor a number therapeutic benefits. Given it is hard to convert full size protein into viable drug, agonists could be designed identified using high-throughput screening. Here, we report on development two-step screening process identify agonists. First step, developed high...
Abstract Salusin β is a multifunctional bioactive peptide and considered as promising candidate biomarker for predicting atherosclerotic cardiovascular diseases. The present study was designed to investigate the roles mechanisms of salusin in paraventricular nucleus (PVN) attenuating hypertension hypothalamic inflammation whether central blockade has protective effects essential hypertension. Normotensive Wistar-Kyoto (WKY) rats spontaneously hypertensive (SHR) were used this study. chronic...
Stimulator of interferon genes (STING) is an integral ER-membrane protein that can be activated by 2'3'-cGAMP synthesized cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) upon binding double-stranded DNA. It activates (IFN) and inflammatory cytokine responses to defend against infection microorganisms. Pharmacologic activation STING has been demonstrated induce antiviral state boost antitumor immunity. We previously reported a cell-based high-throughput-screening assay...
The study investigated the effect of native cassava starch (NCS), hydroxypropylated starch, acetic acid esterification (AAES), acetylated distarch phosphate on gel properties and protein conformation Nemipterus virgatus surimi. Addition 10 g kg-1 NCS or 20 AAES could significantly promote strength textural profiles surimi gels (p < .05). water holding ability whiteness were remarkably increased when four types added at all concentrations In rheological test, lower G' was observed in samples...
Oleanolic acid (OA) and ursolic (UA) are isomeric triterpenic acids only one methyl's position is different between them. OA UA always exist in the same plant, so it difficult to separate them when determining contents by RP-HPLC. In this study, a very simple mobile phase for HPLC was developed simultaneously determine OA, factors affecting separation were also discussed. The methanol: water (95:5) with flow rate 0.4 mL/min. retention time 20.58 21.57 min, respectively, resolution 1.61....
Tumor vascular formation and maintenance are crucial events in glioblastoma development. Mesenchymal stem cells (MSCs) have been shown to differentiate into pericytes contribute neovascularization the glioma microenvironment. Moreover, glioblastoma-derived mesenchymal (gb-MSCs), which consist of CD90-MSCs CD90+MSCs, a subpopulation MSCs that more active vascularization. However, functions gb-MSCs microRNA (miRNA) modifications microenvironment not yet fully elucidated. Here, we focus on...
Inflammation has been implicated in the development of cardiovascular disease. We determined whether nod-like receptor with pyrin domain containing 3 (NLRP3) involved process prehypertension, central blockade NLRP3 decreased inflammation reaction, regulated neurohormonal excitation, and delayed progression prehypertension. Prehypertensive rats were induced by 8% salt diet. The on high-salt diet for 1 month administered a specific blocker hypothalamic paraventricular nucleus (PVN) 4 weeks....
<title>Abstract</title> <bold>Objectives</bold>: The hypertensive process is a chronic low-grade inflammation. Anatabine, natural alkaloid with anti-inflammatory properties, can modulate inflammatory pathways. Therefore, this study sought to explore the impact of anatabine on cardiovascular activity in rats, focusing mechanisms associated inflammation and oxidative stress. <bold>Method</bold>: We collected fecal samples from male spontaneously rats (SHR) Wistar-Kyoto (WKY) (300-350g),...
The internationalization of higher education began to take shape during the period Republic China. This trend manifested in various forms and encompassed a rich array activities, including construction teaching staffs, exchange international students, presence overseas scholars giving lectures Between 1899 1945, Japanese institutions sent nearly 200 academic students With establishment improvement internal system universities China, these were able study interact with Chinese scholars....
Aim: The aim of this study was to compare the efficacy and safety fixed-dose combination (FDC) pioglitazone metformin supplemented with dapagliflozin (test group) those basal insulin (control in patients inadequately controlled type 2 diabetes mellitus (T2DM). Methods: This 16-week, prospective, randomized, open-label enrolled aged 18– 75 years glycated hemoglobin (HbA1c) levels between ≥ 8% ≤ 11%. primary endpoint proportion who achieved HbA1c < 7% at week 16 without hypoglycemia or weight...
A general, efficient and economic copper‐catalyzed α, β‐enones allylic oxidation to 1,4‐enedione has been developed. The protocol only requires a small amount of cheap copper catalyst with air as the sole oxidant. advantages approach are mild reaction conditions, broad substrate scope, good tolerance functional groups, easy experimental operation. demonstrated be compatible for late‐stage functionalization drugs natural products.