A5085438228- Hearing, Cochlea, Tinnitus, Genetics
- Ear Surgery and Otitis Media
- Parasitic Diseases Research and Treatment
- Vestibular and auditory disorders
- Carbohydrate Chemistry and Synthesis
- Chemical synthesis and alkaloids
- Respiratory viral infections research
- Phytochemistry and Bioactivity Studies
- Viral gastroenteritis research and epidemiology
- Viral Infections and Outbreaks Research
- Piperaceae Chemical and Biological Studies
- Hepatitis B Virus Studies
- Biochemical and Structural Characterization
- Acoustic Wave Resonator Technologies
- Transgenic Plants and Applications
- Insects and Parasite Interactions
- RNA regulation and disease
Bionics Institute
2020-2024
The University of Melbourne
2020
Institute for Medical Research
1987-1990
IHVR-19029 (6) is a lead endoplasmic reticulum α-glucosidases I and II inhibitor, which efficiently protected mice from lethal Ebola Marburg virus infections via injection route, but suffered low bioavailability off-target interactions with gut glucosidases when administered orally. In an effort to improve efficacious exposure levels avoid side effects, we designed synthesized ester prodrugs. Not only were the prodrugs stable in simulated gastric intestinal fluids inactive against they also...
Hearing loss is the most common sensory deficit worldwide with no approved therapeutics for treatment. Local neurotrophin delivery into cochlea has shown great potential in protecting and repairing cells important hearing. However, of these factors inner ear at therapeutic levels over a sustained period time remained challenge restricting clinical translation. We have developed method to test pharmacokinetics released from porous silica particles called 'supraparticles' that can provide...
ABSTRACT The known filaricides, suramin and diethylcarbamazine citrate, were tested against subperiodic Brugia malayi infection in the leaf-monkey, Presbytis cristata . As expected, intravenous at 10 mg/kg daily × 5 days or 17 weekly weeks, did not show any microfilaricidal activity, but substantially reduced recovery of live adult worms to 50·6% 13·6% controls respectively. Oral citrate 6 final microfilarial counts 30% initial four weeks post-treatment worm was 4·5% 0% Although antifilarial...
ABSTRACT Four Presbytis cristata were treated with oral ivermectin at the same time as subcutaneous inoculation of 100 infective larvae monthly for three months. Two animals given 0·2 mg/kg and two others 0·3 well control became patent microfilaraemia. However, only 1% dose was recovered adult worms from in higher drug dosage group compared to 8·2% 6·2% lower groups respectively.