A5008032186- Extraction and Separation Processes
- RNA Interference and Gene Delivery
- Metal Extraction and Bioleaching
- Advanced biosensing and bioanalysis techniques
- Fusion materials and technologies
- Recycling and Waste Management Techniques
- Nuclear Materials and Properties
- Ion-surface interactions and analysis
- Advanced X-ray and CT Imaging
- Arsenic contamination and mitigation
- Nanoparticle-Based Drug Delivery
- Diamond and Carbon-based Materials Research
- Metal and Thin Film Mechanics
- Advanced X-ray Imaging Techniques
- Advanced materials and composites
- Hearing, Cochlea, Tinnitus, Genetics
- Fractional Differential Equations Solutions
- Nonlinear Differential Equations Analysis
- Mathematical Dynamics and Fractals
- Medical Imaging Techniques and Applications
- Virus-based gene therapy research
- Minerals Flotation and Separation Techniques
- Chaos control and synchronization
- Ear Surgery and Otitis Media
- Electrodeposition and Electroless Coatings
Northwest University
2024-2025
University of North Carolina at Chapel Hill
2022-2025
Pharmac
2025
China Pharmaceutical University
2024
Jinchuan (China)
2011-2023
The University of Melbourne
2018-2023
Chinese Academy of Sciences
2018-2023
Institute of Electrical Engineering
2018-2023
Bionics Institute
2019-2023
Xi'an Jiaotong University
2023
Abstract Over the last two decades, lipid nanoparticles (LNPs) have evolved as an effective biocompatible and biodegradable RNA delivery platform in fields of nanomedicine, biotechnology, drug delivery. They are novel bionanomaterials that can be used to encapsulate a wide range biomolecules, such mRNA, demonstrated by current successes COVID‐19 mRNA vaccines. Therefore, it is important provide perspective on LNPs for delivery, which further offers useful guidance researchers who want work...
Mesoporous metal–organic networks have attracted widespread interest owing to their potential applications in diverse fields including gas storage, separations, catalysis, and drug delivery. Despite recent advances, the synthesis of with large ordered mesochannels (>20 nm), which are important for loading, separating, releasing macromolecules, remains a challenge. Herein, we report templating strategy using sacrificial double cubic network polymer cubosomes (Im3̅m) synthesize mesoporous...
Hybrid conformal coatings, such as metal–phenolic networks (MPNs) that are constructed from the coordination-driven assembly of natural phenolic ligands, interest in areas including biomedicine, separations, and energy. To date, most MPN coatings have been prepared by immersing substrates solutions containing ligands metal ions, which is a suitable method for coating small or flexible objects. In contrast, more industrially relevant methods patterning large substrates, spray assembly,...
Intracellular delivery of proteins is a promising strategy for regulating cellular behavior and therefore has attracted interest biomedical applications. Despite the emergence various nanoparticle-based intracellular approaches, it remains challenging to engineer versatile system capable responding physiological triggers without need complex chemical synthesis system. Herein, we develop template-mediated supramolecular assembly synthesize protein–polyphenol nanoparticles (NPs) endosomal...
Hypoxia is a common hallmark of human disease that characterized by abnormally low oxygen levels in the body. While effects hypoxia on many small molecule-based drugs are known, its several classes next-generation medications including messenger RNA therapies warrant further study. Here, we provide an efficacy- and mechanism-driven study details how impacts cellular response to mRNA delivered using 4 different chemistries lipid nanoparticles (LNPs, frontrunner class drug delivery vehicles...
A central goal of chemical and drug delivery sciences is to maximize the therapeutic efficacy a given at lowest possible dose. Here, we report generalizable strategy that can be utilized improve mRNA drugs using lipid nanoparticles (LNPs), clinically approved chemistry platforms in Moderna Pfizer/BioNTech COVID-19 vaccines. In brief, our updates LNPs incorporate adenosine triphosphate (ATP) alongside mRNA, modification results upward 79-fold increase LNP-delivered mRNA-encoded protein...
Poly(ethylene glycol) (PEG) particles can be prepared using templating and self-assembly methods endowed with stealth targeting properties for targeted drug delivery.
Abstract Even though lipid nanoparticles (LNPs) can deliver messenger RNA (mRNA) payloads into cells, their efficiency is often limited by endosomal trapping which prevents from acting therapeutically. Improving the percentage of LNPs that escape endosomes and enter cytoplasm therefore an area active research interest could lead to improved safety profiles reduced manufacturing costs mRNA drugs. Here, tannic acid [TA(+) LNPs] are reported as effective delivery platform for payloads. The...
Despite their successful implementation in the COVID-19 vaccines, lipid nanoparticles (LNPs) still face a central limitation delivery of mRNA payloads: endosomal trapping. Improving upon this inefficiency could afford improved drug systems, paving way toward safer and more effective mRNA-based medicines. Here, we present
In this letter, a broadband low-profile dual circularly polarized reflectarray (dual-CP RA) for Ku-band satellite communications is proposed. A novel single-layer metasurface unit cell consisting of functional layer, an air layer and metal plate investigated first. The structure printed on the F4B substrate. can effectively extend bandwidth, overall profile only 0.12λ0, where λ0 represents wavelength at 11.725 GHz. To independently control phase left-handed (LHCP) right-handed (RHCP) waves,...
Supraparticles (SPs) composed of smaller colloidal particles provide a platform for the long-term, controlled release therapeutics in biomedical applications. However, current synthesis methods used to achieve high drug loading and those involving biocompatible materials are often tedious low throughput, thereby limiting translation SPs diverse Herein, we present simple, effective, automatable alginate-mediated electrospray technique assembly robust spherical silica (Si-SPs) long-term (>4...