A5102723164- Urinary Bladder and Prostate Research
- Urinary Tract Infections Management
- Pelvic floor disorders treatments
- Ophthalmology and Visual Impairment Studies
- Visual perception and processing mechanisms
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Autism Spectrum Disorder Research
- COVID-19 diagnosis using AI
- Glycogen Storage Diseases and Myoclonus
- Cancer survivorship and care
- Pain Management and Placebo Effect
- Lung Cancer Treatments and Mutations
- Parkinson's Disease Mechanisms and Treatments
- Gynecological conditions and treatments
- Histone Deacetylase Inhibitors Research
- Uterine Myomas and Treatments
- Congenital Anomalies and Fetal Surgery
- Seedling growth and survival studies
- Aortic Disease and Treatment Approaches
- Cardiac Structural Anomalies and Repair
- Genetics and Neurodevelopmental Disorders
- Delphi Technique in Research
- Pediatric Hepatobiliary Diseases and Treatments
- Cardiovascular Function and Risk Factors
Health Outcomes Solutions (United States)
2014-2023
Akron Children's Hospital
2023
Northeast Ohio Medical University
2023
Massachusetts General Hospital
2023
Harvard University
2023
Missouri State University
2023
California State University, Long Beach
2023
United Imaging Healthcare (China)
2015
University of Auckland
2010
Rationale: Several new drugs for idiopathic pulmonary fibrosis (IPF) are in development. Tools needed to assess whether these benefit patients on outcomes that matter most them. Health-related quality of life (HRQL) is one such outcome. It influenced by many factors, but symptoms and their impacts two strong drivers.Objectives: To develop a questionnaire symptoms, disease impacts, HRQL specifically with IPF.Methods: Working the U.S. Food Drug Administration through Development Tool...
The aim was to develop a clinical outcome assessment (COA) for itching in children with cholestatic pruritus. This prospective study aimed enroll patients aged 4–30 years Alagille syndrome (ALGS) or progressive familial intrahepatic cholestasis type 1 and caregivers of 5 months 14 years. Eligible experienced during ≥3 the 7 days before enrollment had not undergone liver transplant surgical interruption enterohepatic circulation. Open-ended qualitative interviews confirmed that primary...
SIGNIFICANCE Presbyopia typically occurs around 40 years of age and affects approximately one-quarter the global population. Up to October 2021, there were no approved pharmacotherapies for presbyopia, common treatments, such as glasses, can have disadvantages individuals' health-related quality life. PURPOSE This study aimed document experience living with managing identify perspectives on treatment options, determine whether is an unmet need in landscape. METHODS Coded transcripts concept...
Presbyopia is a progressive, age-related visual condition that characterized by reduced ability to focus on near/close objects, causing impacts individuals' daily function and health-related quality of life. The Impact Coping Questionnaire (PICQ) new patient-reported outcome (PRO) instrument assesses presbyopia impact use coping behaviors among presbyopic individuals.To document the associated behaviors, concept elicitation (CE) interviews were conducted with 20 participants. Results from CE...
Aims To develop a comprehensive patient‐reported bladder assessment tool (BAT) for assessing overactive (OAB) symptoms, bother, impacts, and satisfaction with treatment. Methods Subjects were consented eligibility was confirmed by recruiting physician; subjects then scheduled in‐person interviews. For concept elicitation cognitive interviews, 30 20 subjects, respectively, targeted recruitment from US sites. All interviews conducted face‐to‐face, audio‐recorded, transcribed verbatim,...
<b>Utilising consistent terminology and a rigorous approach to determining reporting minimal important change the patient (MICP) would elevate quality of measurement science in our field bolster confidence using PROs as first-tier endpoints</b>https://bit.ly/3OOGNhc
Abstract Background Presbyopia is a progressive condition that reduces the eye’s ability to focus on near objects with increasing age. After systematic literature review identified no existing presbyopia-specific patient-reported outcome (PRO) instruments meeting regulatory guidance, new PRO instrument, Near Vision Task-based Questionnaire (NVPTQ), was developed. Results To explore patient experience presbyopia, concept elicitation interviews were conducted 20 presbyopic participants. The...
Parkinson's disease is a neurodegenerative that can be associated with motor fluctuations result in substantial negative impact to an individual's activities of daily living. Understanding the patient's perspective about therapies important part drug development and shared treatment decision-making. The objective this research was examine structure, scoring, internal consistency, test-retest reliability, concurrent known groups validity Disease Activities Daily Living, Interference...
The sex of an animal impacts glucose sensitivity, but little information is available regarding the mechanisms causing that difference, especially during acute inflammation. We examined sex-specific differences in role P2Y 2 receptor (P2Y R) flux with and without LPS challenge. Male female wild-type R knockout mice -/- ) were injected or saline tolerance tests (GTT) performed. R, insulin receptor, GLUT4 transporter gene expression was also evaluated. Female had reduced fasting plasma females...
Primary mitochondrial myopathies are genetic disorders that primarily affect peripheral skeletal muscles. Patients with primary often experience muscle weakness, fatigue, and other significant impacts on health-related quality of life. The aim this noninterventional qualitative study was to collect the most bothersome fatigue-related symptoms reported by patients determine whether questions included in an existing patient-reported outcome measure, Modified Fatigue Impact Scale, relevant...
A s many of you already know, given the situation surrounding COVID-19 and in response to a June survey where an overwhelming majority AMS members usual Annual Meeting attendees noted that they were not comfortable traveling New Orleans for in-person sessions, we made decision move all oral poster panel discussions, exhibits, some networking 101st virtual format.At time publication, are continuing monitor around looking into options smaller, meeting those who would still like gather, if it...