A5057484166- Inflammatory Bowel Disease
- Microscopic Colitis
- Lung Cancer Treatments and Mutations
- Healthcare Policy and Management
- Multiple Myeloma Research and Treatments
- Global Health Care Issues
- Colorectal Cancer Treatments and Studies
- Economic and Financial Impacts of Cancer
- Vaccine Coverage and Hesitancy
- Cancer Treatment and Pharmacology
- Hereditary Neurological Disorders
- Peripheral Neuropathies and Disorders
- Urinary Bladder and Prostate Research
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Influenza Virus Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Blood Pressure and Hypertension Studies
- Protein Degradation and Inhibitors
- Ocular Surface and Contact Lens
- Allergic Rhinitis and Sensitization
- Celiac Disease Research and Management
- Atrial Fibrillation Management and Outcomes
- Lung Cancer Research Studies
- Gastrointestinal disorders and treatments
Bayer (United States)
2024
AmerisourceBergen (United States)
2015-2023
Health Outcomes Solutions (United States)
2016-2020
Scientific Consulting Group
2019
Health Economics and Outcomes Research (United Kingdom)
2016
Ortho Clinical Diagnostics (United States)
2009
The number of shots represented by the routine childhood immunization schedule poses a logistical challenge for providers and potential deterrent parents. By reducing injections, use combination vaccines could lead to fewer deferred doses improved coverage rates.To determine effect on rates.This was retrospective study administrative claims data from Georgia Department Community Health Medicaid program conducted January through September 2003. Coverage rates were compared between children...
Purpose: To assess the effect of dry eye disease on work productivity and performance non–work-related activities, patients' satisfaction with over-the-counter (OTC) treatments. Methods: In this prospective, noninterventional, cross-sectional study, conducted at 10 U.S. optometry/ophthalmology practices, 158 symptomatic patients naïve to prescription medication underwent standard diagnostic tests completed Work Productivity Activity Impairment (WPAI) Ocular Surface Disease Index (OSDI)...
This study aimed to measure the true burden of COPD by calculating incremental direct and indirect costs. Direct medical resource use, productivity metrics, COPD-specific use costs were also evaluated.
Background: Evidence supporting optimal treatment sequencing in relapsed/refractory multiple myeloma (RRMM) patients requiring therapy lines is lacking.Methods: Using retrospective chart data, this study describes real-world RRMM patterns and related progression-free survival (PFS) US community oncology clinics.Results: Bortezomib ± a non-immunomodulatory drug (IMiD), lenalidomide non-proteasome inhibitor (PI), bortezomib + an IMiD were the most commonly used regimens early of therapy....
To assess end-of-life (EOL) total healthcare costs and resource utilization during the last 6 months of claims follow-up among patients with metastatic breast cancer (MBC) who received systemic anti-neoplastic therapy.Newly diagnosed females MBC initiating treatment January 1, 2003-June 30, 2011 were identified in a large commercial database. Two cohorts defined based on proxy measure for EOL 1 month prior to end recorded within study period: assumed dead at (EOL cohort) alive...
To examine the comorbidity profile and update estimates of health care resource utilization for commercially insured, working-age adults with diabetic macular edema (DME) relative to a matched comparison group without DME. Additional comparisons were made in subgroup pseudophakic patients.A retrospective matched-cohort study insured aged 18-63 years was conducted using medical outpatient pharmacy claims (July 1, 2008-June 30, 2013). Outcomes included diabetes-related ocular comorbidities...
To assess the impact on hospitalization costs of multimodal analgesia (MMA), including intravenous acetaminophen (IV-APAP), versus IV opioid monotherapy for postoperative pain management in patients undergoing orthopedic surgery. Utilizing Truven Health MarketScan® Hospital Drug Database (HDD), total knee arthroplasty (TKA), hip (THA), or surgical repair fracture between 1/1/2011 and 8/31/2014 were separated into groups: MMA with IV-APAP plus other analgesics (IV-APAP group) an group. All...
Background In patients with relapsed/refractory multiple myeloma (RRMM) previously receiving 1–3 therapy lines, newer agents demonstrated improved outcomes versus older agents. Real-world treatment pattern data are limited. We assessed real-world patterns and in RRMM (≥2 prior lines).Research design methods An electronic medical record (EMR) analysis chart review were conducted using International Oncology Network (ION) EMR data. Patients ≥18 years old initiating first-line MM 1 January...
Background: Use of combination vaccines has been associated with improved coverage rates, but their effect on timeliness remains to be explored. This study assessed the diphtheria-tetanus-acellular pertussis/hepatitis B/inactivated polio vaccine (DTaP/HepB/IPV) administration. Methods: retrospective cohort used administrative claims data from Georgia Medicaid program. Children 24 months continuous enrollment and at least 4 vaccine-related office visits were stratified into 2 cohorts: those 3...
International Task Force (ITF) guidelines established a grading scheme to support treatment of dry eye disease based on clinical signs and symptoms. The purpose this study was assess the impact vision-related function across ITF severity levels using Ocular Surface Disease Index (OSDI) questionnaire. Non-interventional, cross-sectional prescription treatment-naïve patients seeking symptom relief at 10 ophthalmology optometry practices. Clinicians assessed corneal conjunctival staining, tear...
Real-world evidence is lacking on the impact of bevacizumab added to carboplatin/paclitaxel (Bev + CP) therapy versus CP alone for patients with non-squamous non-small cell lung cancer (NS-NSCLC), particularly in those excluded from clinical trials. This a retrospective electronic medical record analysis who received first-line Bev or between 1 October 2006 and 30 June 2013. We identified four subsets: elderly (≥65 years), brain/central nervous system (CNS) metastases, Eastern Cooperative...
To characterize newly diagnosed primary open-angle glaucoma (OAG) patients and to describe their treatment journey in United States clinical practice according the use of topical therapy, laser trabeculoplasty, surgical procedures. Retrospective claims database study. Patients with at least 2 diagnoses OAG 7 days or more apart within 1 year, first (index) diagnosis 2010, 30 months continuous enrollment before index no medication (exception for ocular hypertension diagnosis), 48 enrollment....
48 Background: Anecdotal evidence suggests that some pts with mCRC experience significantly longer responses to REG in clinical care settings, including a case exceeding 9 years. However, comprehensive studies on long-term responders are lacking. We evaluated demographic/clinical characteristics of response (LTR) using duration treatment (DOT) as surrogate for response. Methods: This was retrospective cohort study the US nationwide de-identified Flatiron Health Electronic Record-derived...
Importance The conditions required for health record data sources to accurately assess treatment effectiveness remain unclear. Emulation of randomized clinical trials (RCTs) with and subsequent calibration the results can help elucidate this. Objective To pilot an emulation KEYNOTE-189 RCT using a commercially available electronic (EHR) source. Design, Setting, Participants This retrospective cohort study used EHR database spanning from April 2007 February 2023. Follow-up began on initiation...
Objective: To evaluate the burden of major bleed in patients with non-ST segment elevation acute coronary syndromes (NSTE ACS) receiving injectable anticoagulation from hospital perspective.Methods: Retrospective analysis inpatient medical and pharmacy data Premier Perspective Comparative Database between 1/1/2003 3/31/2006. Hospitalized aged ≥18 years a diagnosis UA or NSTEMI who received an anticoagulant agent during same stay were stratified into two cohorts: those experienced...
To compare the impact of comorbid hypertension and diabetes on resource utilization costs compared to mellitus (DM) or (HTN) alone.A retrospective claims analysis assessed economic trends in patients without pre-existing CV disease three cohorts: newly-treated HTN-only, DM-only, HTN DM (comorbid cohort). Total, CV-specific, DM-specific measured for up 24 months were classified into five categories: inpatient, outpatient, emergency department (ED), physician, other medical. Costs using linear...
Objective:Although Remicade (infliximab) is costly relative to non-biologic therapy, its impact on healthcare resource utilization and mucosal healing may make it a cost-effective option. This study aimed compare gastrointestinal (GI)-related severity of damage before during infliximab therapy in Crohn’s disease (CD) or ulcerative colitis (UC) patients.Methods:A retrospective chart review was conducted at 14 gastroenterology practices from across the country, which varied practice sizes...
Infliximab dosing for inflammatory bowel disease (IBD) is based on patient weight and treatment response. Understanding patterns may provide insight into response predictability of cost. The purpose this medical record review was to assess dose frequency infliximab maintenance in patients with IBD using chart data.A retrospective conducted at 14 community gastroenterology clinics (GI clinics). Patients were aged ≥18 years, diagnosed Crohn's (CD) or ulcerative colitis (UC), had a first...
A1 Effects of enhanced recovery pathways on renal function Charles R. Horres, Mohamed A. Adam, Zhifei Sun, Julie K. Thacker, Timothy J. Miller, Stuart Grant A2 Economic outcomes after surgery (ERAS) Jeffrey Huang A3 What does eating, drinking and mobilizing really mean? Kirstie McPherson, Sanjiv Patel, Su Cheen Ng, Denise Veelo, Bart Geerts, Monty Mythen A4 Intra-operative fluid monitoring practices Mark Foulger, Tim Collins, Michael A5 Development an integrated perioperative medicine care...