A5101624810- Angiogenesis and VEGF in Cancer
- Thyroid Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Cardiac Ischemia and Reperfusion
- Tissue Engineering and Regenerative Medicine
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Retinoids in leukemia and cellular processes
- Cardiac electrophysiology and arrhythmias
- Connexins and lens biology
- Nitric Oxide and Endothelin Effects
- Growth Hormone and Insulin-like Growth Factors
- Advanced Glycation End Products research
- Anesthesia and Neurotoxicity Research
- Chemical Analysis and Environmental Impact
- Cardiac Fibrosis and Remodeling
- Autophagy in Disease and Therapy
- Congenital heart defects research
- Immune cells in cancer
- Effects and risks of endocrine disrupting chemicals
- Circular RNAs in diseases
- Pulmonary Hypertension Research and Treatments
- Mesenchymal stem cell research
- Mitochondrial Function and Pathology
- Inflammasome and immune disorders
Xuzhou Medical College
2015-2025
Zhejiang Chinese Medical University
2024-2025
Health Canada
2007-2024
Lyceum of the Philippines University
2024
Affiliated Hospital of Xuzhou Medical College
2006-2023
Wuhan Donghu University
2023
Shantou University Medical College
2021
Linyi People's Hospital
2012-2021
Shantou University
2021
Northeastern University
2020
Abstract More and more evidence indicates that circular RNAs (circRNAs) have important roles in several diseases, especially cancers. However, their involvement remains to be investigated breast cancer. Through screening circRNA profile, we identified 235 differentially expressed circRNAs Subsequently, explored the clinical significance of two circTADA2As a large cohort triple-negative cancer (TNBC), performed functional analysis circTADA2A-E6 vitro vivo support findings. Finally, evaluated...
Thyroid hormone (TH) is critical to normal brain development, but the mechanisms operating in this process are poorly understood. We used chromatin immunoprecipitation enrich regions of DNA bound thyroid receptor beta (TRbeta) mouse cerebellum sampled on post natal day 15. Enriched target was hybridized promoter microarrays (ChIP-on-chip) spanning -8 kb +2 transcription start site (TSS) 5000 genes. identified 91 genes with TR binding sites. Roughly half sites were located introns, while 30%...
Pigment epithelium-derived factor (PEDF) has many biological activities. But it's not known whether PEDF and its functional peptides could protect against hypoxia-induced cell death the mechanisms are still unclear. We used cultured H9c2 cells primary cardiomyocytes to show that apoptosis necroptosis were significantly increased after hypoxia. Both fuctional 44mer reduced rates inhibited expression of cleaved caspase 3 receptor-interacting protein (RIP3). Furthermore, up-regulate super oxide...
This is a series of three cases diagnosed with xanthogranulomatous inflammation the female genital emphasis on etiology, clinical-pathologic features and biological behavior. Clinical, pathologic, radiologic follow up data are reported.The Xanthogranulomatous tract followings: 1) one case affecting endometrium, 2) fallopian tube, 3) confined to ovary. The patient's age was 37, 22 62 year-old, respectively. Histologic examination revealed extensive infiltration foamy histiocytes admixed...
Furan is a widely used industrial chemical and contaminant in heated foods. Chronic furan exposure causes cholangiocarcinoma hepatocellular tumors rats at doses of 2 mg/kg bw/day or greater, with gender differences frequency severity. The hepatic transcriptional alterations induced by low (doses below those previously tested for induction liver tumors) the potential mechanisms underlying are largely unexplored. We DNA microarrays to examine global mRNA microRNA profiles male female exposed...
The sex-determining region Y-box 4 (SOX4), a transcription factor, is involved in various developmental processes. It has been reported multiple human cancers. However, the prognostic value and its exact role chondrosarcoma remain poorly understood. In current study, SOX4 was overexpressed 28 of 92 (30.4 %) interpretable patients compared with 3 43 (6.9 chondroma cases (P = 0.003). Its overexpression significantly associated histological grade < 0.001) presence tumor recurrence 0.041)....
ABSTRACT Saikosaponin b1 (Ssb1), a natural oleanane‐type triterpenoid saponin, exhibits antifibrosis activity by inhibiting the activation of hepatic stellate cells (HSCs), but specific underlying molecular mechanisms are unknown. Here, it is found that Ssb1 could directly bind with signal transducer and activator transcription 3 (STAT3) effectively inhibit HSCs. Proteomic techniques simulation revealed mainly bound to S319 residues STAT3 in coiled‐coil domain. Further studies indicated...
Pigment epithelium-derived factor (PEDF) is a pleiotropic gene with anti-inflammatory, antioxidant and anti-angiogenic properties. However, recent reports about the effects of PEDF on cardiomyocytes are controversial, it not known whether how acts to inhibit hypoxic or ischemic endothelial injury in heart. In present study, adult Sprague-Dawley rat models acute myocardial infarction (AMI) were surgically established. PEDF-small interfering RNA (siRNA)-lentivirus (PEDF-RNAi-LV) PEDF-LV was...
// Ling Chen 1, 2 , Guangming Kong 3 Chuantao Zhang 1 Hongyan Dong 4 Cuicui Yang Guanhua Song 5 Chengye Guo Lin Wang 6 Hongsheng Yu Department of Oncology, Affiliated Hospital Qingdao University, Qingdao, China Municipal Hospital, Emergency Department, Pathology, Linyi People's Linyi, Institute Basic Medicine, Shandong Academy Medical Sciences, Jinan, Research Center for Medicinal Biotechnology, Key Laboratory Rare and Uncommon Diseases Province, Correspondence to: Yu, e-mail:...
The nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome has been linked to sterile inflammation, which is involved in ischemic injury myocardial cells. Pigment epithelium-derived factor (PEDF) a multifunctional secreted glycoprotein with many biological activities, such as anti-inflammatory, antioxidant and anti-angiogenic properties. However, it not known whether how PEDF acts regulate the activation of NLRP3 cardiomyocytes. In present study, we used...
MicroRNAs (miRNAs) are extensively involved in diverse biological processes. However, very little is known about the role of miRNAs mediating action thyroid hormones (TH). Appropriate TH levels to be critically important for development, differentiation and maintenance metabolic balance mammals. We induced transient hypothyroidism juvenile mice by short-term exposure methimazole perchlorate from post natal day (PND) 12 15. The expression liver was analyzed using Taqman Low Density Arrays...
Thyroid hormones (THs) play important roles in almost all physiological processes. High-throughput screening (HTS) assays are needed to screen the vast numbers of chemicals for their potential disrupt TH signalling. The current work has confirmed ability a rapid assay identify substances inhibiting uptake through monocarboxylate transporter (MCT) 8. Perturbation MCT8 function results significant developmental impairments, suggesting may be toxicants. We examined accuracy and consistency...
Pigment epithelium-derived factor (PEDF) is a 50-kDa secreted glycoprotein that highly expressed in cardiomyocytes. A variety of peptides derived from PEDF exerts diverse physiological activities including anti-angiogenesis, antivasopermeability, and neurotrophic activities. Recent studies demonstrated segmental functional PEDF, 44mer peptide (Val78–Thr121), show similar cytoprotective effect to the holoprotein. We found can reduce infarct size protect cardiac function after acute myocardial...
Pigment epithelial-derived factor (PEDF) is known to exert diverse physiological activities. Previous studies suggest that hypoxia could induce mitophagy. Astoundingly, under hypoxic condition, we found PEDF decreased the mitochondrial density of cardiomyocytes. In this study, evaluated whether decrease and play a protective role in cardiomyocytes via promoting Immunostaining western blotting were used analyze mitophagy Gas chromatography‑mass spectrometry ELISA levels palmitic acid...
The prevention and management of myocardial ischemia/reperfusion (MI/R) injury is an essential part coronary heart disease surgery becoming a major clinical problem in the treatment ischemic disease. Previous studies by our group have demonstrated that pigment epithelium‑derived factor (PEDF) improves cardiac function rats with acute infarction reduces hypoxia‑induced cell injury. However, protective mechanisms underlying effect PEDF MI/R remain to be fully understood. In present study,...
Endothelial mesenchymal transition (EndMT) plays a critical role in the pathogenesis and progression of interstitial perivascular fibrosis after acute myocardial infarction (AMI). Pigment epithelium-derived factor (PEDF) is shown to be new therapeutic target owing its protective cardiovascular disease. In this study, we tested hypothesis that PEDF an endogenous inhibitor EndMT represented novel mechanism for effects against overactive cardiac AMI. Masson's trichrome (MTC) staining...