A5101880975- Analytical Chemistry and Chromatography
- Chromatography in Natural Products
- Traditional Chinese Medicine Analysis
- Genetic factors in colorectal cancer
- Tea Polyphenols and Effects
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Supramolecular Self-Assembly in Materials
- Cancer-related Molecular Pathways
- Pharmacological Effects and Toxicity Studies
- Liver physiology and pathology
- Genomics, phytochemicals, and oxidative stress
- Food Quality and Safety Studies
- Advanced Chemical Sensor Technologies
- Oral microbiology and periodontitis research
- Glioma Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Brain Metastases and Treatment
- Cancer Mechanisms and Therapy
- Nephrotoxicity and Medicinal Plants
- Aldose Reductase and Taurine
- Natural product bioactivities and synthesis
- Chromatin Remodeling and Cancer
- Sirtuins and Resveratrol in Medicine
- Heavy Metals in Plants
Zhejiang Chinese Medical University
2011-2025
The Third Affiliated Hospital of Zhejiang Chinese Medical University
2025
Second People’s Hospital of Huai’an
2016
Xuzhou Medical College
2016
Nanjing University of Chinese Medicine
2013-2014
Early detection is critical in prevention and treatment of kidney disease. However currently clinical laboratory histopathological tests do not provide region-specific accurate biomarkers for early The present study was conducted to identify sensitive progression tubulo-interstitial nephropathy aristolochic acid I-induced rats at weeks 4, 8 12. Biomarkers were validated using (AAN) week 24, adenine-induced chronic disease (CKD) CKD patients. Compared with control rats, AAN showed anemia,...
Changes in plasma concentration of small organic metabolites could be due to their altered production or urinary excretion and changes urine may the filtered load, tubular reabsorption, and/or volume. Therefore, these factors should considered interpretation observed target metabolite(s). Fasting samples from 180 CKD patients 120 age-matched healthy controls were determined by UPLC-HDMS-metabolomics quantitative real-time RT-PCR techniques. Compared with controls, showed activation NF-κB...
ABSTRACT Saikosaponin b1 (Ssb1), a natural oleanane‐type triterpenoid saponin, exhibits antifibrosis activity by inhibiting the activation of hepatic stellate cells (HSCs), but specific underlying molecular mechanisms are unknown. Here, it is found that Ssb1 could directly bind with signal transducer and activator transcription 3 (STAT3) effectively inhibit HSCs. Proteomic techniques simulation revealed mainly bound to S319 residues STAT3 in coiled‐coil domain. Further studies indicated...
To investigate the association between mitochondrial events and immune response in periodontitis related regulatory genes. Gene expression profiles gingival tissues were retrieved from Expression Omnibus. Mitochondria-immune response-related differentially expressed genes (MIR-DEGs) healthy samples determined. WGCNA, GO, KEGG used to function enriched pathways of MIR-DEGs. The correlation MIR-DEGs clinical probing pocket depth was analyzed. further identified verified animal samples. A model...
Abstract Peptide‐drug conjugates (PDCs) are a type of self‐assembled prodrug with good potential for drug delivery due to their excellent biocompatibility, high loading, and permanent controllable release. However, most PDCs tend self‐assemble into filamentous nanostructures in water under physiological conditions, making them unsuitable as intravenous formulations the entanglement long fibers risk thrombus. Injected also face challenges overcoming complex environment reach target site. To...
Flos Lonicerae Japonicae (FLJ) is a popular herb used for many centuries in Traditional Chinese Medicine as treatment of fever and inflammation. Non-fumigated processing FLJ has been the traditional approach post-harvest preparation commodity commercial use. However, recent years, natural drying replaced by sulfur-fumigation efficiency pest control. Sulfur-fumigation can induce changes volatile compounds herb, altering its medicinal properties. A comprehensive two-dimensional gas...
This study is to explore the effect of total flavonoids from Radix Tetrastigmae (TF) against hepatic cancer and discuss acting mechanism. Proliferation HepG2 cells was promoted by PGE2 Butaprost. Using AH6809 as positive control, inhibitory TF on additional cell line detected through a CCK-8 assay, apoptosis rate flow cytometry, nuclear morphology were observed Hochest33258 staining. Then PCR applied determine mRNA expression. The corresponding Protein expression determined Western Blot....
ABSTRACT Sulfur‐fumigation is known to reduce volatile compounds that are the main active components in herbs used herbal medicine. We investigated changes chemical composition between sun‐dried and sulfur‐fumigated Radix Angelicae Dahuricae using a purge trap technique capture compounds, two‐dimensional gas chromatography/time‐of‐flight mass spectrometry for identification. Using samples as reference, results showed 73 including 12 sulfide were found be present only samples. Furthermore, 32...
This study is designed for the clinical characteristics and prognostic factors of central neurocytoma (CN).CN patients from 2004 to 2012 were enrolled Surveillance Epidemiology End Results (SEER) data. Clinical including age, sex, race, tumor size, number, surgery, radiation therapy summarized. Univariate multivariate analysis performed explore CN.CN tended be borderline malignant single lesion. Compared with other brain (NCN), Patients CN (CNs) more likely female, young, non-white race....
Baizhu Shaoyao San (BSS) is a famous traditional Chinese medicinal prescription, which composed of Rhizome atractylodis macrocephalae, Radix Paeoniae Alba, Pericarpium Citri Reticulatae and Saposhnikovia. In this study, simple sensitive high-performance liquid chromatography coupled with diode array detection method was established for the simultaneous determination 10 marker compounds including atractylenolide I, gallic acid, albiflorin, paeoniflorin, narirutin, hesperidin, nobiletin,...
To characterize the chemical differences of volatile components between crude and processed Baizhu Shaoyao San (BSS), a classical Chinese herbal formula that is widely applied in treatment gastrointestinal diseases, we developed gas chromatography–mass spectrometry-based needle trap device combined with multivariate data analysis to globally profile rapidly identify differentiating markers. Using triple-bed packed Carbopack X, DVB Carboxen 1000 sorbents, identified 121 123 compounds,...
Background: Sulfur-fumigation of Angelicae sinensis Radix causes changes in the structure and composition volatile components. These alter curative effect quality A. Radix. Materials Methods: In this study, comprehensive two-dimensional gas chromatography coupled with time-of-flight mass spectrometry (GC × GC-TOFMS) was employed to investigate influence sulfur-fumigation on components, characterize quantify chemical oil Results: The present study has shown that sulfur-fumigated samples had...
Chinese medicine processing is the characteristic and advantage of traditional medicine, which also an important discipline with independent intellectual property rights in China. To clarify mechanism key point research, node modernization. The mechanisms most are unclear at present, need systematically deeply research. Coffee bean to be roasted under high temperature before being made into beverage, very similar processing. In recent years, scientists all over world have done lots research...
Abstract The purpose of this paper is to investigate the immune function tumor microenvironment and its clinical correlation with colonic carcinoma. Immune genes were downloaded from Cancer Genome Atlas database. Five subtypes are obtained by cluster screening based on gene expression data. C3 C4 show stronger activity. In addition, subtype has largest number mutations worst prognosis. Most signatures upregulated in subtype, while most infiltration‐related cells subtypes. different...
Colon adenocarcinoma (COAD) is a common malignant tumor of the digestive tract that threatens human health seriously. Thus, it urgent to explore biomarkers can be used evaluate patient's survival prognosis overall as supplementary treatment. RNA-seq expression profiles were downloaded from The Cancer Genome Atlas and Gene Expression Omnibus, Lasso multivariate Cox regression analyses for developing prognostic model. Finally, nomogram comprising model was established overall. A risk comprised...