A5100747697- Acute Kidney Injury Research
- Cell Adhesion Molecules Research
- HER2/EGFR in Cancer Research
- Chronic Lymphocytic Leukemia Research
- Chronic Kidney Disease and Diabetes
- Cancer-related molecular mechanisms research
- Cardiac Arrest and Resuscitation
- Traditional Chinese Medicine Analysis
- Sepsis Diagnosis and Treatment
- RNA modifications and cancer
- COVID-19 Clinical Research Studies
- Autophagy in Disease and Therapy
- Ferroptosis and cancer prognosis
- Cancer-related Molecular Pathways
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Chromatography in Natural Products
- Ginseng Biological Effects and Applications
- Metabolomics and Mass Spectrometry Studies
- Dialysis and Renal Disease Management
- Metal complexes synthesis and properties
- Crystal structures of chemical compounds
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Medical Research and Treatments
- Sirtuins and Resveratrol in Medicine
Zhejiang Cancer Hospital
2015-2025
Zhejiang University
2019-2025
Wenzhou Medical University
2025
Chengdu University of Traditional Chinese Medicine
2025
Zhumadian Central Hospital
2025
Chinese PLA General Hospital
2013-2024
Shanghai Jiao Tong University
2024
Weifang Medical University
2024
First Affiliated Hospital of Xi'an Jiaotong University
2020-2024
North China University of Science and Technology
2020-2024
The Runt domain transcription factors (RUNXs) play essential roles in normal development and neoplasias. Genetic analyses of animals humans have revealed the involvement RUNX1 hematopoiesis leukemia, RUNX2 osteogenesis cleidocranial dysplasia, RUNX3 T-cells dorsal root ganglion neurons genesis gastric cancer. Here we report that is a target acetyltransferase activity p300. p300-dependent acetylation three lysine residues protects from ubiquitin ligase Smurf-mediated degradation. extent...
Abstract The purpose of this study was to permit bone marrow mesenchymal stem cells (BMSCs) reach their full potential in the treatment chronic wounds. A biocompatible multifunctional crosslinker based temperature sensitive hydrogel developed deliver BMSCs, which improve inflammation microenvironments detailed vitro investigation found that is suitable for BMSC encapsulation and can promote secretion TGF-β1 bFGF. In vivo , full-thickness skin defects were made on backs db/db mice mimic...
Resistance to anti-ErbB2 agents is a significant problem in the treatment of human ErbB2+ breast cancers. We show here that adhesion cancer cells basement membrane laminin-5 provides substantial resistance trastuzumab and lapatinib, respectively target extracellular kinase domains ErbB2. Knockdown laminin-binding integrins (alpha6beta4, alpha3beta1) or associated tetraspanin protein CD151 reversed sensitized lapatinib. knockdown, together with treatment, inhibited ErbB2 activation downstream...
BACKGROUND: Corona Virus Disease-2019 (COVID-19) is an acute respiratory infectious disease. Despite being clinically cured, some patients still find it difficult to return their normal life and work due the varying degree of dysfunctions that they have, as part disease's aftereffect. Through this study, we aim learn more about rehabilitation needs COVID-19 patients.METHODS: In survey, basic information, dysfunctions, hospitalized patients, who were selected by convenience sampling in Hubei...
Accumulation of evidence suggests that the gut microbiome, its specific metabolites, and differentially expressed proteins (DEPs) are related to non-small cell lung cancer (NSCLC) pathogenesis. We now report influences microbiota, DEPs on mediation NSCLC's chronic inflammation immune dysregulation.We conducted 16S ribosomal RNA sequencing for microbiome in healthy volunteers NSCLC patients. Liquid chromatography-mass spectrometry (LC-MS) analysis was employed explore differences between...
ABSTRACT Upon viral infection, the major defense mounted by host immune system is activation of interferon (IFN)-mediated antiviral pathway. In order to complete their life cycles, viruses must modulate IFN-mediated response. The K3 and K5 proteins a human tumor-inducing herpesvirus, Kaposi's sarcoma-associated herpesvirus (KSHV), have been shown downregulate surface expression modulatory receptors increasing endocytosis rates, which leads suppression cell-mediated immunity. this report, we...
ErbB2+ human breast cancer is a major clinical problem. Prior results have suggested that tetraspanin CD151 might contribute to ErbB2-driven growth, survival, and metastasis. In other types, sometimes supports tumor growth However, definitive test of effects on de novo initiation, metastasis has not previously been done. We used gene-deleted mice expressing the MMTV-ErbB2 transgene show strongly mammary initiation Delayed onset (by 70-100 days) in absence was accompanied by reduced survival...
Objectives In a 24/7 society, the negative metabolic effects of rotating night shift work have been increasingly explored. This study aimed to examine association between and non-alcoholic fatty liver disease (NAFLD) in steelworkers. Methods A total 6881 subjects was included this study. Different exposure metrics including current status, duration shifts (years), cumulative number (nights), length (hours), average frequency (nights/month) (hours/night) were used relationship NAFLD. Results...
Gastric cancer (GC) is one of the most common causes cancer-related death worldwide. As a novel form programmed cell death, disulfidptosis characterized by excessive cysteine accumulation, disulfide stress and actin destruction. There evidence that targeting promising anticancer strategy. Further improvement GC risk stratification based on has positive clinical significance. We analyzed expression levels disulfidptosis-associated genes (DPAGs) in normal tissues molecular subtypes patients....
PANoptosis is a newly discovered form of programmed cell death (PCD), involving the interaction cellular pyroptosis, apoptosis, and necroptosis. Although plays significant role in carcinogenesis process, impact PANoptosis-related lncRNAs (PANlncRNAs) on prognostic value mechanism immune infiltration gastric cancer have not been studied. All information (GC) patients was downloaded from TCGA database. genes were obtained molecular characteristic databases, PANlncRNAs screened through Pearson...
Abstract A significant challenge in cancer therapy is the identification of suitable targets that are specifically and uniformly expressed across heterogeneous tumors. The efficacy pre‐existing antiviral immunity tumor treatment limited by absence corresponding targets. This study develops a novel platform antigen‐targeted inserted nanomicelles, preS1 (an antigen hepatitis B virus)‐pHLIP which tumor‐targeting nanomicelles release antigens label tissue for immunity‐mediated lysis situ. In...
Obesity is a major global health problem that significantly increases the risk of many other diseases. Herein, facile method suppressing lipogenesis and obesity using L-arginine-functionalized carbon dots (L-Arg@CDots) reported. The prepared CDots with negative surface charge form stronger bonds than D-arginine lysine L-Arg in water. L-Arg@CDots aqueous solution offer high photoluminescence quantum yield 23.6% red wavelength region. proposed functionalization strategy not only protects...