A5101754715- Cardiac Imaging and Diagnostics
- Cytomegalovirus and herpesvirus research
- Viral-associated cancers and disorders
- Cardiovascular Function and Risk Factors
- Infective Endocarditis Diagnosis and Management
- Herpesvirus Infections and Treatments
- Coronary Interventions and Diagnostics
- RNA Interference and Gene Delivery
- Amyotrophic Lateral Sclerosis Research
- Cardiac Structural Anomalies and Repair
- Nerve injury and regeneration
- Pericarditis and Cardiac Tamponade
- Cardiac Valve Diseases and Treatments
- Alzheimer's disease research and treatments
- Venous Thromboembolism Diagnosis and Management
- Cardiac tumors and thrombi
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- Cardiac Arrhythmias and Treatments
- Psychosocial Factors Impacting Youth
- Renal and Vascular Pathologies
- Atrial Fibrillation Management and Outcomes
- Renin-Angiotensin System Studies
- Bacterial Identification and Susceptibility Testing
- Neuroinflammation and Neurodegeneration Mechanisms
Jeonbuk National University
2014-2025
Korea Institute of Oriental Medicine
2012-2025
National Cancer Institute
2024
Government of the Republic of Korea
2024
National University Hospital
2024
Chonbuk National University Hospital
2010-2023
Seoul National University
1993-2023
Seoul National University Hospital
2008-2023
National University College
2022-2023
New Generation University College
2022-2023
Efficient genetic modification of herpesviruses such as Kaposi's sarcoma-associated herpesvirus (KSHV) has come to rely on bacterial artificial chromosome (BAC) technology. In order facilitate this approach, we generated a new KSHV BAC clone, called BAC16, derived from the rKSHV.219 virus, which stems and Epstein-Barr virus-coinfected JSC1 primary effusion lymphoma (PEL) cells. Restriction enzyme complete sequencing data demonstrate that PEL cells showed minimal level sequence variation...
Mavacamten has shown promise in obstructive hypertrophic cardiomyopathy (oHCM); however, real-world evidence is limited Asians. We aimed to provide the first multicenter, analysis of mavacamten use Korea. This prospective observational study included symptomatic oHCM patients treated at 7 tertiary hospitals Changes key parameters, including left ventricular outflow tract (LVOT) gradients, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and New York Heart Association functional class...
An important step in the herpesvirus life cycle is switch from latency to lytic reactivation.The RTA transcription activator of Kaposi's sarcoma-associated (KSHV) acts as a molecular for reactivation.Here we demonstrate that KSHV recruits CBP, SWI/SNF chromatin remodeling complex, and TRAP/Mediator coactivator into viral promoters through interactions with short acidic sequence carboxyl region this recruitment essential RTA-dependent gene expression.The Brg1 subunit TRAP230 were shown...
ABSTRACT On viral infection, infected cells can become the target of host immune responses or go through a programmed cell death process, called apoptosis, as defense mechanism to limit ability virus replicate. To prevent this, viruses have evolved elaborate mechanisms subvert apoptotic process. Here, we report identification novel antiapoptotic K7 protein Kaposi's sarcoma-associated herpesvirus (KSHV) which expresses during lytic replication. The KSHV gene encodes small mitochondrial...
The ruthenium complex [Cp(iPr3P)Ru(NCCH3)2]+ (1) catalyzes the regioselective hydrosilylation of pyridines to 1,4-dihydropyridines. Substitution in 3- and 5-positions is tolerated, whereas with substituents 2-, 4-, 6-positions are not reduced. Reduction functionalized having keto ester results a mixture products. N-Silyl-1,4-dihydropyridine reacts ketones aldehydes give products N–Si addition across C═O bond. Hydrosilylation pyridine acetone quantitatively product PhMe2SiO–CMe2–NC5H6, which...
Scutellaria baicalensis has been extensively employed for the clinical treatment of hyperlipidemia, atherosclerosis, hypertension, dysentery, inflammatory diseases, and common cold. The present study was performed to investigate anti‐obesity anti‐dyslipidemia effect extracts (SBE) in type 2 diabetic db/db mice. Male mice were divided into three groups ( n = 5) orally administrated vehicle (control), SBE 10, 100 mg/kg body weight/day 4 weeks everyday. Administration improves weight gain,...
The replication and transcription activator (RTA) of gamma-2 herpesvirus is sufficient to drive the entire virus lytic cycle. Hence, control RTA activity should play an important role in maintenance viral latency. Here, we demonstrate that cellular poly(ADP-ribose) polymerase 1 (PARP-1) Ste20-like kinase hKFC interact with serine/threonine-rich region these interactions efficiently transfer phosphate units RTA. Consequently, modifications strongly repressed RTA-mediated transcriptional...
Kaposi's sarcoma (KS) is a multifocal angiogenic tumor and appears to be hyperplastic disorder caused, in part, by local production of inflammatory cytokines. The K1 lymphocyte receptor-like protein KS-associated herpesvirus (KSHV) efficiently transduces extracellular signals elicit cellular activation events through its cytoplasmic immunoreceptor tyrosine-based motif (ITAM). To further delineate K1-mediated signal transduction, we purified signaling complexes identified components. Upon...
Angiotensin-(1-7) [ANG-(1-7)] plays a counterregulatory role to angiotensin II in the renin-angiotensin system. In trained spontaneous hypertensive rats, Mas expression and protein are upregulated ventricular tissue. Therefore, we examined of ANG-(1-7) on cardiac hemodynamics, functions, remodeling two-kidney one-clip (2K1C) rats. For this purpose, rats were divided into sedentary groups. Each group consists sham 2K1C with without infusion. Swimming training was performed for 1 h/day, 5...
Ca2+ signaling plays a fundamental role in cardiac hypertrophic remodeling, but the underlying mechanisms remain poorly understood. We investigated of Ca2+-mobilizing second messengers, NAADP and cADPR, hypertrophy induced by β-adrenergic stimulation isoproterenol. Isoproterenol an initial transients followed sustained rises. Inhibition cADPR pathway with 8-Br-cADPR abolished only increase, whereas inhibition bafilomycin-A1 both rapid phases isoproterenol-mediated signal, indicating that...
Amyotrophic lateral sclerosis (ALS) is a multicomplex neurodegenerative disorder characterized by motor neuron death, muscle atrophy, and respiratory failure. Owing to its mechanisms multifactorial nature in the skeletal spinal cord (SC), no effective therapy has been developed. However, herbal medicines, known for their multitarget properties, have demonstrated promising efficacy with limited side effects treating various diseases. Specifically, Paeonia lactiflora Pallas exhibit analgesic,...
Reactive oxygen species (ROS) are implicated in reperfusion injury after transient focal cerebral ischemia. The antioxidant enzyme, Cu,Zn-superoxide dismutase (SOD), is one of the major means by which cells counteract deleterious effects ROS Recently, we reported that when Tat-SOD fusion protein transduced into pancreatic β it protects from destruction relieving oxidative stress ROS-implicated diabetes (Eum et al., 2004). In present study, investigated protective against neuronal cell death...
We evaluated the performance of Vitek MS for identification Gram-positive cocci routinely isolated in clinical microbiology laboratories. With a total 424 well-characterized isolates, results were compared to those conventional methods and 16S rRNA gene sequencing. The correctly identified 97.9 % isolates tested species level. 97.2 staphylococci (95.9 coagulase-negative staphylococci), 97.8 streptococci, 100 enterococci. For overall concordance rate between was 94.5 %. matrix-assisted laser...
Air pollution is a risk factor that increases cardiovascular morbidity and mortality. In this study, we investigated the cardiotoxicity of particulate matter (PM) exposure using zebrafish embryo model. We found PM induced cardiotoxicity, such as arrhythmia, during cardiac development. caused by altering expression levels development (T-box transcription 20, natriuretic peptide A, GATA-binding protein 4)- ion-channel (scn5lab, kcnq1, kcnh2a/b, kcnh6a/b)-related genes. conclusion, study showed...
Frailty frequently coexists with hypertension in older patients. We aimed to evaluate the association between frailty and positional change blood pressure, especially orthostatic hypertension.
Recent studies have documented that Janus-activated kinase (JAK)–signal transducer and activator of transcription (STAT) pathway can modulate the apoptotic program in a myocardial ischemia/reperfusion (I/R) model. To date, however, limited examined role JAK3 on I/R injury. Here, we investigated potential effects pharmacological inhibition with JANEX-1 Mice were subjected to 45 min ischemia followed by varying periods reperfusion. was injected 1 h before intraperitoneal injection. Treatment...