A5082336809- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- SARS-CoV-2 and COVID-19 Research
- Virus-based gene therapy research
- Probiotics and Fermented Foods
- Sirtuins and Resveratrol in Medicine
- Nanoparticles: synthesis and applications
- T-cell and B-cell Immunology
- Entomopathogenic Microorganisms in Pest Control
- Immunotherapy and Immune Responses
- Food Quality and Safety Studies
- Pediatric health and respiratory diseases
- Viral Infections and Immunology Research
- Nematode management and characterization studies
- Animal Disease Management and Epidemiology
- Cytokine Signaling Pathways and Interactions
- Agriculture, Soil, Plant Science
- NF-κB Signaling Pathways
- Forest Insect Ecology and Management
- Pharmacological Effects of Natural Compounds
- Herpesvirus Infections and Treatments
- Planarian Biology and Electrostimulation
- Autophagy in Disease and Therapy
Chungbuk National University
2015-2024
National University College
2022
New Generation University College
2022
Jeonbuk National University
2011-2021
Korea University
2021
Hanbuk University
2017
International Ginseng & Herb Research Institute
2015
Hallym University
2015
Chonbuk National University Hospital
2014
Korea Forest Service
2012-2013
Although many self-reactive T cells are eliminated by negative selection in the thymus, some of these escape into periphery, where they must be controlled additional mechanisms. However, molecular mechanisms underlying peripheral cell tolerance and its maintenance remain largely undefined. In this study, we report that sirtuin 1 (Sirt1), a type III histone deacetylase, negatively regulates activation plays major role clonal anergy mice. vivo, found loss Sirt1 function resulted abnormally...
Objective Sirtuin 6 (SIRT‐6) is an NAD + ‐dependent deacetylase and mono‐ADP‐ribosyltransferase. It known to interfere with the NF‐κB signaling pathway thereby has antiinflammatory function. Due central role of in rheumatoid arthritis (RA) development, we undertook this study test our hypothesis that SIRT‐6 could have antiarthritic effects. Methods An adenovirus containing complementary DNA (Ad‐SIRT6) was used deliver human RA fibroblast‐like synoviocytes vitro as well mice collagen‐induced...
Microvilli on T cells have been proposed to survey surfaces of antigen-presenting (APC) or facilitate adhesion under flow; however, whether they serve essential functions during cell activation remains unclear. Here we show that antigen-specific deposit membrane particles derived from microvilli onto the surface cognate antigen-bearing APCs. carry receptors (TCR) at all stages and are released as large TCR-enriched, (TMP) in a process trogocytosis. These exclusively contain protein...
The NAD-dependent histone deacetylase Sirt1 is a negative regulator of T cell activation. Here we report that inhibits activation by suppressing the transcription Bcl2-associated factor 1 (Bclaf1), protein required for Sirt1-null cells have increased acetylation 3 lysine 56 residue (H3K56) at bclaf1 promoter, as well increasing Bclaf1 transcription. binds to promoter upon receptor (TCR)/CD28 stimulation forming complex with acetyltransferase p300 and NF-κB Rel-A. recruitment Sirt1, but not...
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an infectious with multiple symptoms, such as fever over 37.5°C, cough, dyspnea, and pneumonia.In our research, microRNAs (miRNAs) binding to the genome sequences of (SARS-CoV), Middle East respiratory-related (MERS-CoV), SARS-CoV-2 were identified bioinformatic tools.Five miRNAs (hsa-miR-15a-5p, hsa-miR-15b-5p, hsa-miR-195-5p, hsa-miR-16-5p, hsa-miR-196a-1-3p) found commonly bind...
Extracellular vesicles (EVs) are cell-released, nanometer-scaled, membrane-bound materials and contain diverse contents including proteins, small peptides, nucleic acids. Once released, EVs can alter the microenvironment regulate a myriad of cellular physiology components, cell–cell communication, proliferation, differentiation, immune responses against viral infection. Among cargoes in vesicles, non-coding micro-RNAs (miRNAs) have received attention that they expression variety human genes...
Porcine reproductive and respiratory syndrome (PRRS) is 1 of the most economically important diseases swine. Detection etiologic agent, PRRS virus (PRRSV), represents a diagnostic challenge due to heterogeneity field isolates as well propensity for swine develop persistent infection in which difficult detect. Recently European (EU) lineage PRRSV isolates, are genetically divergent from North American (NA) have been introduced into NA further complicating efforts diagnose this disease. In...
Treg differentiation, maintenance, and function are controlled by the transcription factor FoxP3, which can be destabilized under inflammatory or other pathological conditions. Tregs conditions, but underlying mechanisms not fully defined. Herein, we show that cytokines induce ER stress response, destabilizes suppressing FoxP3 expression, suggesting a critical role of response in maintaining stability. Indeed, genetic deletion Hrd1, an E3 ligase leads to elevated expression stress-responsive...
A previously unknown SARS-CoV-2 vaccine protecting nonhuman primates from challenge was developed using RBD-P2 and N.
In this study, characteristics and immuno-modulatory effects of Weissella cibaria JW15 isolated from Kimchi, traditional Korean fermented food, were examined for investigation the capacity potentially probiotic strains. We measured acid, bile, heat tolerance, adhesive properties to intestinal epithelial cells, inhibitory activity against pathogens. could survive at pH 3.0 2 hr, but not 2.0. also showed tolerance 0.3% oxgall bile salt, 70°C 80°C 5 min, respectively. Adhesive ability Caco-2...