A5101601897- interferon and immune responses
- Cytokine Signaling Pathways and Interactions
- Influenza Virus Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Immune cells in cancer
- Viral Infections and Immunology Research
- RNA Interference and Gene Delivery
- Immune Response and Inflammation
- Antimicrobial Peptides and Activities
- Viral Infections and Vectors
- Diabetes and associated disorders
- NF-κB Signaling Pathways
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- SARS-CoV-2 and COVID-19 Research
- RNA and protein synthesis mechanisms
- Medical Imaging Techniques and Applications
- Virus-based gene therapy research
- High Altitude and Hypoxia
- Polar Research and Ecology
- Viral gastroenteritis research and epidemiology
- Radiomics and Machine Learning in Medical Imaging
- Winter Sports Injuries and Performance
- T-cell and B-cell Immunology
Catholic University of Korea
2013-2023
Bucheon St. Mary's Hospital
2013
Abstract As agonists of TLR7/8, single‐stranded RNAs (ssRNAs) are safe and promising adjuvants that do not cause off‐target effects or innate immune overactivation. However, low stability prevents them from mounting sufficient responses. This study evaluates the adjuvant ssRNA derived cricket paralysis virus intergenic region internal ribosome entry site, formulated as nanoparticles with a coordinative amphiphile, containing zinc/dipicolylamine complex moiety phosphate binder, stabilizer for...
Abstract Pathogenic T helper cells (T H ) and macrophages have been implicated in the development of rheumatoid arthritis (RA), which can lead to severe synovial inflammation bone destruction. A range therapies widely used for RA, including specific monoclonal antibodies chemical inhibitors against inflammatory cytokines produced by these cells. However, not sufficient meet medical need. Here, we show that transgenic mice expressing truncated IK (tIK) cytokine, symptoms were ameliorated as...
Inhibitor K562 (IK) protein was first isolated from the culture medium of K562, a leukemia cell line. It is known to be an inhibitory regulator interferon-γ-induced major histocompatibility complex class (MHC) II expression. Previously, we found that transgenic (Tg) mice constitutively expressing truncated IK (tIK) showed reduced numbers pathogenic Th1 and Th17 cells, which are involved in development rheumatoid arthritis (RA). Here, investigated whether exogenous tIK has therapeutic effect...
Abstract As agonists of TLR7/8, single‐stranded RNAs (ssRNAs) are safe and promising adjuvants that do not cause off‐target effects or innate immune overactivation. However, low stability prevents them from mounting sufficient responses. This study evaluates the adjuvant ssRNA derived cricket paralysis virus intergenic region internal ribosome entry site, formulated as nanoparticles with a coordinative amphiphile, containing zinc/dipicolylamine complex moiety phosphate binder, stabilizer for...
ABSTRACT Although most influenza vaccines are produced in eggs, new types of must be developed. In this study, the immunogenicity and safety a baculovirus‐expressed hemagglutinin (HA) H1N1 virus (Korea/01/2009; designated “HA‐Bac‐K”) was compared with those commercially available HA (designated “HA‐Bac‐C”) an Escherichia coli ‐expressed “HA‐ E. Coli ‐K”). HA‐Bac‐K succeeded inducing hemagglutination inhibition neutralization antibodies mouse ferret models. The different immunogenicities...
Abstract The pathogenesis of inflammatory autoimmune rheumatoid arthritis (RA) is driven by the activation macrophage, and development pathogenic interferon-γ (IFN-γ)- producing interleukin-17 (IL-17)- CD4+ T cells (TH1 TH17). Here we showed that truncated IK (tIK) cytokine, inhibitor IFN-γ induced MHC class II expression, ameliorated RA in a mouse model, which was associated with decreases joint swelling bone destruction, as well incidence. However, detailed mechanism tIK-reduced still...
Abstract Influenza virus is a pathogenic negative-sense RNA belonging to the Orthomyxoviridae, which causes severe respiratory illness worldwide. A vaccine against influenza best way control spread of influenza. Recently, cell-based was developed overcome disadvantages egg-based vaccines. Here, we investigated whether forskolin, an adenylyl cyclase activator, could increase output vaccine. We found that forskolin increased propagation three subtypes, A/H1N1/California/4/09,...
Abstract The truncated IK (tIK) cytokine is known for its ability to downregulate the major histocompatibility complex class II on antigen-presenting cells and regulate immune activation in inflammatory diseases by suppressing differentiation of pathogenic T macrophage. Because these regulatory functions, previous research has proposed tIK as a new candidate autoimmune disease therapy such that rheumatoid arthritis (RA). However, immunological mechanism still not identified clearly. In this...
Barbosa, Andres ... et. al.-- IX Simposio de Estudios Polares del Comite Espanol Scientific Committee on Antarctic Research (SCAR), 5-7 September 2018, Madrid, Espana.-- 1 page