A5100725343- Alzheimer's disease research and treatments
- Plant Stress Responses and Tolerance
- Immune Cell Function and Interaction
- Plant responses to water stress
- Cholinesterase and Neurodegenerative Diseases
- Plant Molecular Biology Research
- CAR-T cell therapy research
- Virus-based gene therapy research
- Xenotransplantation and immune response
- Fungal Biology and Applications
- Animal Genetics and Reproduction
- Cancer Immunotherapy and Biomarkers
- Ear Surgery and Otitis Media
- Plant-Microbe Interactions and Immunity
- Computational Drug Discovery Methods
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
- Ear and Head Tumors
- interferon and immune responses
- Immunotherapy and Immune Responses
- Insect and Pesticide Research
- Neurobiology and Insect Physiology Research
- Photosynthetic Processes and Mechanisms
- Tracheal and airway disorders
- Postharvest Quality and Shelf Life Management
Pukyong National University
2025
Andong National University
2019-2024
Ulsan College
2020-2024
Asan Medical Center
2020-2024
University of Ulsan
2020-2024
University of Florida
2024
Yonsei University
2017-2023
Gyeongsang National University
2023
Korea Institute of Brain Science
2022
Korea Institute of Science and Technology
2022
Abstract Clinical trials are evaluating the efficacy of anti-TIGIT for use as single-agent therapy or in combination with programmed death 1 (PD-1)/programmed death-ligand blockade. How and whether a TIGIT blockade will synergize immunotherapies is not clear. Here, we show that CD226loCD8+ T cells accumulate at tumor site have an exhausted phenotype impaired functionality. In contrast, CD226hiCD8+ tumor-infiltrating possess greater self-renewal capacity responsiveness. Anti-TIGIT treatment...
Alzheimer's disease (AD), the most common cause of dementia, is a complex condition characterized by multiple pathophysiological mechanisms including amyloid-β (Aβ) plaque accumulation and neuroinflammation in brain. The current immunotherapy approaches, such as anti-Aβ monoclonal antibody (mAb) therapy, Aβ vaccines, adoptive regulatory T (Treg) cell transfer, target single mechanism, which may lead to unsatisfactory therapeutic efficacy. Furthermore, vaccines often induce helper 1 (Th1)...
Abstract Background Cardiopulmonary resuscitation (CPR) is the cornerstone intervention for cardiac arrest, with extracorporeal CPR (ECPR) demonstrating enhanced survival and neurologic outcomes in in‐hospital arrest. This study explores time interval between initiation onset of membrane oxygenation (ECMO) ECPR recipients, investigating its impact on outcomes. Methods retrospective analysis included 1950 adults who received at a single medical center March 2019 April 2023. Data from 198...
Background The lower trapezius (LT) involves scapular depression and retraction so, the strategy is expected to increase LT activity during prone Y exercise. Objective To investigate effects of three different strategies exercise on muscle activities, ratios, positions in participants with dyskinesis (SD). Method: Twenty male SD participated, upper (UT), middle (MT), activities were evaluated using surface electromyography conditions: 1) arm lifting, 2) intended 3) roller-assist. In...
Chemotherapeutic agents induce irreversible gonadotoxic side effects, resulting in endocrine dysfunction and infertility female cancer survivors. In the current study, we investigated strategies to protect ovarian function from chemotherapy-induced toxicity by evaluating effects of cisplatin, doxorubicin, or cyclophosphamide on vasculature primordial follicle survival. This investigation was conducted using adult CD-1, postnatal 5-7 oocyte-specific Trp63 conditional knockout (Trp63 cKO) mice...
Adenylate cyclase 3 (ADCY3) is a widely expressed membrane-associated protein in human tissues, which catalyzes the formation of cyclic adenosine-3',5'-monophosphate (cAMP). However, our transcriptome analysis gastric cancer tissue samples (NCBI GEO GSE30727) revealed that ADCY3 expression was specifically altered samples. Here we investigated tumor-promoting effects overexpression and confirmed significant correlation between upregulation Lauren's intestinal-type cancers. increased cell...
Stimulator of interferon genes (STING) is an endoplasmic reticulum-membrane protein that plays important roles in cancer immunotherapy by activating innate immune responses. We designed and synthesized STING modulators characterized compounds 4a 4c share a crucial amidobenzimidazole moiety. In vitro binding cell-based activity assays demonstrated the potency efficacy function as direct agonists stimulating downstream signaling promoting type I metabolic studies pharmacokinetic properties led...
Hemp (Cannabis sativa L.) is used for medicinal purposes owing to its anti-inflammatory and antioxidant activities. We evaluated the protective effect of nanovesicles isolated from hemp plant parts (root, seed, sprout, leaf) in dextran sulfate sodium (DSS)-induced colitis mice. The particle sizes root-derived (RNVs), seed-derived (SNVs), sprout-derived (HSNVs), leaf-derived (LNVs) were within range 100-200 nm as measured by nanoparticle tracking analysis. Acute was induced C57BL/N mice 5%...
Abstract Pyroglutamate amyloid-β 3-42 (Aβ pE3-42 ) is an N-terminally truncated and pyroglutamate-modified Aβ peptide retaining highly hydrophobic, amyloidogenic, neurotoxic properties. In Alzheimer’s disease (AD) patients, peptides accumulate into oligomers induce cellular toxicity synaptic dysfunction. aggregates further seed the formation of amyloid plaques, which are pathological hallmarks AD. Given that play critical roles in development neurodegeneration, a reliable reproducible...
Amyloid-β (Aβ) oligomers are implicated in Alzheimer disease (AD). However, their unstable nature and heterogeneous state disrupts elucidation of explicit role AD progression, impeding the development tools targeting soluble Aβ oligomers. Herein parallel anti-parallel variants Aβ(1-40) dimers were designed synthesized, pathogenic properties models characterized. Anti-parallel induced cognitive impairments with increased amyloidogenesis cytotoxicity, this dimer was then used a screening...
Abnormal assembly of amyloid β (Aβ) in the brain is implicated Alzheimer's disease (AD) and associated with cognitive impairments. Since Aβ accumulation occurs advance onset clinical symptoms, identifying preventable drug candidates regulating regarded as a promising approach AD therapeutic. Herein, we synthesized eight Yonsei Institute pharmaceutical sciences Drug (YIAD) compounds based on 5-benzyl-6-phenylbenzo[4,5]imidazo[1,2-a]pyrrolo[2,1-c]pyrazine structures. Subsequently, YIAD-0203...
Here, we report the quantification of porcine endogenous retrovirus (PERV) copy numbers using real time PCR. After generating standard curves plasmid DNA, were determined for PERV pol and a housekeeping gene, estrogen receptor2 (ER2) with same amount genomic DNA. Using this method, examined 6 pig breeds in Korea including two miniature pig, one domestic from Jeju, imported breeds, Duroc, Landrace, Yorkshire. All showed ranging 9 to 50. This method will be useful monitoring PERVs xenograft.
Low-oxygen stress, mainly caused by soil flooding, is a serious abiotic stress affecting crop productivity worldwide. To understand the mechanisms of low-oxygen responses and adaptation plants, we characterized compared in six species with different accessions Brassicaceae family. Based on growth survival to submergence or condition, these could be divided into three groups: (i) Highly tolerant (
Abstract Amyloid‐β (Aβ) in the form of neurotoxic aggregates is regarded as main pathological initiator and key therapeutic target Alzheimer's disease. However, anti‐Aβ drug development has been impeded by lack a needed for structure‐based design low permeability blood–brain barrier (BBB). An attractive strategy amyloid‐based peptidomimetics that exploit self‐assembling nature Aβ penetrate BBB. Herein, we designed dimeric peptide candidate based on N‐terminal fragment Aβ, DAB, found to cross...
Aggregated amyloid-β (Aβ) is considered a pathogenic initiator of Alzheimer's disease (AD), in strong association with tau hyperphosphorylation, neuroinflammation, synaptic dysfunction, and cognitive decline. As the removal amyloid burden from AD patient brains by antibodies has shown therapeutic potential, development small molecule drugs inducing chemical dissociation clearance Aβ compelling as strategy. In this study, we synthesized screened aryloxypropanolamine derivatives identified...