A5100358405- interferon and immune responses
- Immune Response and Inflammation
- Synthetic Organic Chemistry Methods
- Cytokine Signaling Pathways and Interactions
- Click Chemistry and Applications
- Nanoplatforms for cancer theranostics
- Cancer Treatment and Pharmacology
- Asymmetric Synthesis and Catalysis
- Luminescence and Fluorescent Materials
- Ubiquitin and proteasome pathways
- Viral Infections and Vectors
- Molecular Sensors and Ion Detection
- Neuroinflammation and Neurodegeneration Mechanisms
- Tannin, Tannase and Anticancer Activities
- Monoclonal and Polyclonal Antibodies Research
- Nanomaterials for catalytic reactions
- Mitochondrial Function and Pathology
- Advanced Nanomaterials in Catalysis
- Tea Polyphenols and Effects
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Inflammasome and immune disorders
- Genetics and Neurodevelopmental Disorders
- Cancer, Hypoxia, and Metabolism
- Porphyrin and Phthalocyanine Chemistry
Korea Institute of Science and Technology
2018-2025
GI Innovation (South Korea)
2023-2025
Kyung Hee University
2024-2025
Hanyang University
2014-2024
Korea Institute of Brain Science
2018-2024
Korean Association Of Science and Technology Studies
2020-2024
Northwestern University
2024
Pusan National University
2024
Korea Basic Science Institute
2023
Catholic University of Korea
2021-2022
Cocyclization of alkynes, alkenes, and carbon monoxide by rhodium(I) catalysts was realized for the first time. Contrary to previously employed late transition metals, these possess tunable ligands that make this reaction more versatile.
Photoaffinity-based target identification has received recent attention as an efficient research tool for chemical biology and drug discovery. The major obstacle of photoaffinity-based is the nonspecific interaction between probes nontarget proteins. Consequently, rational design photoaffinity linkers been spotlighted successful identification. These interactions have considered random events, therefore no systematic investigation conducted regarding proteins linkers. Herein, we report...
Upconversion nanoparticles (UCNPs), which can be excited by near-infrared (NIR) light, are attractive in the field of photodynamic therapy (PDT). However, PDT efficiency conventional UCNPs is limited due to low quantum yield and overheating effect 980 nm light source. Here, we synthesized NaYF4:Yb,Er,Nd@NaYF4:Yb,Nd with dual photosensitizers. We used 808 as an excitation source Nd-doped solve effect, core@shell structure increase upconversion emission efficiency. also utilized dual-color...
Abstract Here, antigen and adjuvant encapsulated dendritic cell‐targeted nanoparticles for immune activation in the small intestinal lymphatic system to inhibit melanoma development are described. This strategy is demonstrated using chondroitin sulfate‐coated (OPGMN) grafted with glycocholic acid mannose cationic liposomes ovalbumin as an polyinosine‐polycytidylic a cancer‐specific adjuvant. OPGMN absorbed gastrointestinal tract delivered lymph nodes when orally administered. Oral delivery...
Background Adenosine accumulated in the tumor microenvironment functions as an immune-modulating factor, exerting immunosuppressive actions via adenosine A2A/A2B receptor (A2AR/A2BR) various immune cell types. CD73, a key enzymatic regulator responsible for production, is frequently overexpressed diverse cancers, and its overexpression associated with reduced responsiveness to conventional anti-cancer drug treatments such chemotherapy, radiation therapy, targeted or immunotherapy. Despite...
Abstract Parkinson's disease (PD) is a progressive neurodegenerative caused by loss of dopaminergic neurons in the substantia nigra. Monoamine oxidase‐B (MAO‐B) inhibition promising strategy for modification. Here, we synthesized series 2,6‐diarylbenzo[ d ]oxazoles and identified two potent selective hMAO‐B inhibitors: 4,4′‐(benzo[ ]oxazole‐2,6‐diyl)diphenol 4a (IC 50 = 0.182 μM) 4‐(2‐(3‐fluorophenyl)benzo[ ]oxazol‐6‐yl)phenol 4f 0.184 μM). Molecular modeling indicated that benzoxazole core...
Stimulator of interferon genes (STING) is an endoplasmic reticulum-membrane protein that plays important roles in cancer immunotherapy by activating innate immune responses. We designed and synthesized STING modulators characterized compounds 4a 4c share a crucial amidobenzimidazole moiety. In vitro binding cell-based activity assays demonstrated the potency efficacy function as direct agonists stimulating downstream signaling promoting type I metabolic studies pharmacokinetic properties led...
Histone deacetylases (HDACs) are key epigenetic regulators and classified into four subtypes. Despite the various roles of each HDAC isoform, lack selective inhibitors has limited elucidation their in biological systems. HDAC11, sole class-IV HDAC, is highly expressed brain, however, role HDAC11 microglia not fully understood. Based on modification MC1568, we developed a novel inhibitor, 5. Interestingly, 5 suppresses lipopolysaccharide-induced microglial activation by initiation autophagy...
By taking advantage of a unique mechanism aggregation-induced emission (AIE) phenomena, AIE luminogens (AIEgens) have been provided as solution to overcome the limitations conventional fluorophores bearing feature aggregation-caused quenching (ACQ) phenomena. Especially, AIEgens paved way develop fluorogenic probes ideal for fluorescent imaging in live cell conditions. Despite high demand discovery new AIEgens, it is still challenging find versatile molecular platform generate diverse...
Abstract Although cetuximab (CTX) is a chimeric epidermal growth factor receptor (EGFR) antibody, the antitumor efficacy of CTX has negligible effect in patients with Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) mutated pancreatic adenocarcinoma. Given that all extant treatments are ineffective due to undruggable characteristics KRAS ‐mutated cancer, alternative strategies have been investigated. In this work, CTX‐conjugated maleimide‐polyethylene glycol‐chlorin e6 (CMPC) designed...
Fluorescent tracers for glucose-uptake monitoring could be used as chemical tools diagnosis and discovery of novel therapeutic agents via the development phenotypic screening systems. Here we present a new near-infrared fluorescent glucose tracer, Glc-SiR-CO2H, cellular uptake. By conjugating glucosamine with two different silicon rhodamine fluorochromes, found that net charge fluorochromes has considerable effects on uptake probe. Competition assay d/l-glucose well Western blot analysis...
A lack of the T cell-inflamed tumor microenvironment limits efficacy immune checkpoint inhibitors (ICIs). Activation stimulator interferon genes (STING)-mediated innate immunity has emerged as a novel therapeutic approach in cancer therapy. 2′,3′-Cyclic GMP–AMP (cGAMP) is natural STING agonist; however, cGAMP subjected to endogenous degradation by ecto-nucleotide pyrophosphatase phosphodiesterase 1 (ENPP1). To improve ICI response rate, we developed 29f, ENPP1 inhibitor with...
Because mitochondria are essential organelles for regulating energy homeostasis and intrinsic apoptosis, the perturbation of mitochondrial functions has been considered as an anticancer treatment. In this study, a new near-infrared (NIR) fluorescent probe, SiR-Mito11 was developed theragnostic agent brain tumor by targeting mitochondria. exhibited potential activity against glioma cells but tolerance in normal neuronal cells. We further confirmed that selective accumulation disrupted...
In cancer immunotherapy, the cyclic GMP-AMP synthase-stimulator of interferon genes (STING) pathway is an attractive target for switching tumor immunophenotype from 'cold' to 'hot' through activation type I response. To develop a new chemical entity STING activator improve (cGAMP)-induced innate immune response, we identified KAS-08 via structural modification DW2282, which was previously reported as anti-cancer agent with unknown mechanism. Further investigation revealed that direct binding...
Platinum nanodots were synthesized inside ZIF-8/Fe<sub>3</sub>O<sub>4</sub> core–shell hybrid nanoparticles without additional reducing agents, which showed high catalytic activity for the reduction of 4-nitrophenol.