A5082625046- Mesenchymal stem cell research
- Telomeres, Telomerase, and Senescence
- Cardiac Ischemia and Reperfusion
- Cardiac Fibrosis and Remodeling
- interferon and immune responses
- Tissue Engineering and Regenerative Medicine
- Neuroscience and Neural Engineering
- Extracellular vesicles in disease
- Signaling Pathways in Disease
- Piezoelectric Actuators and Control
- Electric Power Systems and Control
- Spine and Intervertebral Disc Pathology
- Autism Spectrum Disorder Research
- Medical Imaging and Analysis
- Immune Response and Inflammation
- Viral Infections and Vectors
- Genetics and Neurodevelopmental Disorders
- Control Systems in Engineering
- Periodontal Regeneration and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Musculoskeletal pain and rehabilitation
- Pluripotent Stem Cells Research
- Virus-based gene therapy research
Korea Institute of Science and Technology
2022-2023
Korea Institute of Brain Science
2022-2023
Seoul National University
2020-2022
Abstract Cancer immunotherapies, including adoptive T cell transfer and immune checkpoint blockades, have recently shown considerable success in cancer treatment. Nevertheless, transferred cells often become exhausted because of the immunosuppressive tumor microenvironment. Immune contrast, can reinvigorate cells; however, therapeutic efficacy is modest 70–80% patients. To address some challenges faced by current treatments, here T‐cell‐membrane‐coated nanoparticles (TCMNPs) are developed...
Intervertebral disc (IVD) degeneration (IVDD) is a leading cause of chronic low back pain. There strong clinical demand for more effective treatments IVDD as conventional provide only symptomatic relief rather than arresting progression. This study shows that senolytic therapy with local drug delivery can inhibit and restore IVD integrity. ABT263, drug, loaded in poly(lactic-co-glycolic acid) nanoparticles (PLGA-ABT) intradiscally administered into injury-induced rat models. The single...
Ischemic stroke is one of the leading causes death, and even timely treatment can result in severe disabilities. Reperfusion ischemic region restoration blood supply often lead to a series cellular biochemical consequences, including generation reactive oxygen species (ROS), expression inflammatory cytokines, inflammation, cerebral cell damage, which collectively called ischemia-reperfusion (IR) injury. Since ROS cytokines are involved IR injury, injury could involve senescence. Thus, we...
Abstract Severe cardiac damage following myocardial infarction (MI) causes excessive inflammation, which sustains tissue and often induces adverse remodeling toward function impairment heart failure. Timely resolution of post‐MI inflammation may prevent development Cell therapy approaches for MI are time‐consuming costly, have shown marginal efficacy in clinical trials. Here, nanoparticles targeting the immune system to attenuate infarcted myocardium presented. Liposomal loaded with antigens...
Abstract Osteoarthritis (OA) is a painful intractable disease that significantly affects patients' quality of life. However, current therapies, such as pain killers and joint replacement surgery, do not lead to cartilage protection. Mesenchymal stem cells (MSCs) have been proposed an alternative strategy for OA therapy because MSCs can secrete chondroprotective anti‐inflammatory factors. interleukin‐4 (IL‐4), potent cytokine, barely produced by MSCs, MSC suffers from rapid death following...
The vast majority of drug-eluting stents (DES) elute either sirolimus or one its analogues. While limus drugs stymie vascular smooth muscle cell (VSMC) proliferation to prevent in-stent restenosis, their antiproliferative nature is indiscriminate and limits healing the endothelium in stented vessels, increasing risk late-stent thrombosis. Oxidative stress, which associated with injury from stent implantation, can induce VSMCs undergo senescence, senescent produce pro-inflammatory cytokines...
Recombinant human bone morphogenetic protein 2 (rhBMP-2) is one of the most potent osteogenic factors used to treat loss. However, at higher doses, rhBMP-2 does not necessarily increase formation but rather increases incidence adverse side effects. Here, we investigated whether umbilical cord mesenchymal stem cell (UCMSC)-derived nanovesicles (NVs) further in vivo high doses rhBMP-2. In presence UCMSC-derived NVs, proliferation, migration, and tube vein endothelial cells were stimulated...
The stimulator of the interferon gene (STING) signaling pathway acts as a primary defense system against DNA pathogens. Because crucial role STING in type I (IFN) response and innate immunity, extensive research has been conducted to elucidate roles various effector molecules involved STING-mediated signal transduction. However, despite substantial contribution microtubules immune system, association between remains unclear. In this study, we revealed that modulation via...