Changgi Hong

ORCID: 0000-0003-4324-1392
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Research Areas
  • Electrospun Nanofibers in Biomedical Applications
  • 3D Printing in Biomedical Research
  • Wound Healing and Treatments
  • Fuel Cells and Related Materials
  • Polydiacetylene-based materials and applications
  • Hydrogels: synthesis, properties, applications
  • Antimicrobial Peptides and Activities
  • Tissue Engineering and Regenerative Medicine
  • Image Processing Techniques and Applications
  • Advanced Chemical Sensor Technologies
  • Planarian Biology and Electrostimulation
  • Advanced Nanomaterials in Catalysis
  • Analytical Chemistry and Sensors
  • Cancer Cells and Metastasis
  • Angiogenesis and VEGF in Cancer
  • Electrochemical sensors and biosensors
  • RNA Interference and Gene Delivery
  • Membrane Separation Technologies
  • CAR-T cell therapy research
  • Ocular Surface and Contact Lens
  • Mesenchymal stem cell research
  • Cell Image Analysis Techniques
  • Olfactory and Sensory Function Studies
  • Advanced biosensing and bioanalysis techniques
  • Cellular Mechanics and Interactions

Seoul National University
2021-2024

Advanced Institute of Convergence Technology
2023-2024

Ajou University
2020

Ontario Institute for Cancer Research
2002

University of Toronto
2002

Wound dressings have been designed to provide the optimal environment fibroblasts, keratinocytes, and macrophages promote wound healing while inhibiting potential microbial infection. Gelatin methacrylate (GelMA) is a photopolymerizable hydrogel with gelatin backbone that contains natural cell binding motifs such as arginine–glycine–aspartic acid (RGD) MMP-sensitive degradation sites, making it an ideal material for dressing. However, GelMA alone unable stably protect regulate cellular...

10.1021/acsabm.3c00014 article EN ACS Applied Bio Materials 2023-04-14

Wound dressings made from natural-derived polymers are highly valued for their biocompatibility, biodegradability, and biofunctionality. However, natural polymer-based hydrogels can come with own set of limitations, such as low mechanical strength, limited cell affinity, the potential cytotoxicity cross-linkers, which delineate boundaries usage hamper practical application. To overcome limitation polymers, this study utilized a mixture oxidized alginate gelatin 5 mg/mL polycaprolactone...

10.1021/acs.biomac.4c00406 article EN Biomacromolecules 2024-06-25

Many studies have recently produced artificial enzymes with metal nanoparticles (NPs) to overcome the limitations of natural enzymes, such as low stability, high cost, and storage problems. In particular, gold NPs exhibit peroxidase-like activity are strongly influenced by external parameters, pH, temperature, size, shape, functional layer, which change enzyme activity. Here, chitosan-capped multibranched Au-Ag-Pt (CCNPs) that mimic peroxidase were synthesized using various...

10.1021/acsomega.2c04129 article EN cc-by-nc-nd ACS Omega 2022-11-02

Rheumatoid arthritis (RA) is known to be caused by autoimmune disorders and can partially alleviated through Disease-Modifying Antirheumatic Drugs (DMARDs) therapy. However, due significant variations in the physical environment condition of each RA patient, types doses DMARDs prescribed differ greatly. Consequently, there a need for platform based on patient-derived cells determine effectiveness specific individual patients. In this study, we established an three-dimensional (3D) spheroid...

10.1016/j.mtbio.2024.101061 article EN cc-by-nc-nd Materials Today Bio 2024-04-22

Critical limb ischemia (CLI) is a devastating disease characterized by the progressive blockage of blood vessels. Although paracrine effect growth factors in stem cell therapy made it promising angiogenic for CLI, poor survival harsh ischemic microenvironment limited its efficacy. Thus, an imperative need exists stem-cell delivery method that enhances survival. Here, collagen microgel (CMG) cell-delivery scaffold (40 × 20 μm) was fabricated via micro-fragmentation from collagen-hyaluronic...

10.1016/j.bioactmat.2023.12.008 article EN cc-by-nc-nd Bioactive Materials 2023-12-16

Abstract Traditional two-dimensional (2D) cell culture methodologies exhibit significant limitations, notably their failure to replicate the intricate three-dimensional (3D) milieu of human tissue architecture. This discrepancy has catalyzed exploration advanced drug screening platforms that more faithfully mimic complex 3D biological environment. To this end, precision medicine research increasingly used in vitro models emulate microenvironment body. In study, breast cancer lines...

10.21203/rs.3.rs-3736468/v1 preprint EN cc-by Research Square (Research Square) 2023-12-12

Journal Article Chromophore Mapping via Low-Energy Loss Imaging in a Modified EM902: Formation of the Immune Synapse Get access CW Hong, Hong Ontario Cancer Institute and Department Medical Biophysics, University Toronto, 610 Ave., Ontario, M5G 2M9, Canada Search for other works by this author on: Oxford Academic Google Scholar AB Fernandes, Fernandes JA Davis, Davis JM Penninger, Penninger Microscopy Microanalysis, Volume 8, Issue S02, 1 August 2002, Pages 634–635,...

10.1017/s1431927602106118 article EN Microscopy and Microanalysis 2002-08-01
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