A5100330078- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Cardiovascular Syncope and Autonomic Disorders
- Heart Rate Variability and Autonomic Control
- Head and Neck Anomalies
- Blood Pressure and Hypertension Studies
- Pharmacogenetics and Drug Metabolism
- Parkinson's Disease Mechanisms and Treatments
- Adipose Tissue and Metabolism
- Advanced Fiber Laser Technologies
- Customer Service Quality and Loyalty
- Vestibular and auditory disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Photonic Crystal and Fiber Optics
- Biochemical Analysis and Sensing Techniques
- Diabetes Treatment and Management
- Drug Transport and Resistance Mechanisms
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Neurological disorders and treatments
- Technology Adoption and User Behaviour
- Advanced Fiber Optic Sensors
- Analytical Methods in Pharmaceuticals
- Adipokines, Inflammation, and Metabolic Diseases
- Lipid metabolism and disorders
Vanderbilt University Medical Center
2020-2025
Korea University
2015-2025
Korea University Medical Center
2018-2025
Inje University
1995-2024
Mokpo National University
2014-2023
Kangwon National University
2018-2022
Vanderbilt University
2022
Kangwon National University Hospital
2021
Ewha Womans University Medical Center
2021
Korea Institute of Science and Technology
2004-2020
Abstract It has been reported that asprosin is a novel adipokine which augmented in mice and humans with type 2 diabetes (T2DM). Asprosin stimulates hepatic gluconeogenesis under fasting conditions. However, the roles of inflammation, endoplasmic reticulum (ER) stress, insulin resistance skeletal muscle not studied. In currents study, elevated levels expression were observed adipocytes hyperlipidemic Treatment C2C12 myocytes asprosin‐induced ER stress markers (phosphorylated...
Objectives: In the past few decades, use of natural compounds, such as flavonoids, anti-inflammatory agents has gained much attention. Our current study focuses on preventive effects quercetin, apigenin, and luteolin cytokine-induced β-cell damage. Methods: Pancreatic β-cells or islets were treated with cytokine mixtures in presence absence flavonoids inhibitory effect against toxicity was determined. Results: Treatment RINm5F (RIN) rat insulinoma cells interleukin 1β (IL-1β) interferon γ...
Dabigatran etexilate (DABE), a prodrug of dabigatran (DAB), is direct thrombin inhibitor used to prevent ischemic stroke and thromboembolism during atrial fibrillation. The effect genetic polymorphisms on its metabolism, particularly UGT2B15, has not been extensively explored in humans. This study aimed investigate the effects ABCB1, CES1 pharmacokinetics DAB acylglucuronide metabolites healthy subjects. A total 124 males were genotyped for polymorphisms. After single 150 mg dose DABE,...
In recent years, the advances in wireless communication and electronics have accelerated to develop many network solutions replace existing wired networks. A solution can support mobility flexibility of nodes a network. Especially sensor networks, it has advantages cables with logical links. On other hand, Bluetooth is generally considered as promising short-range technology because its inexpensive cost, low power small size, thus been gaining increasing interest from various industries. For...
This study is to investigate at the molecular level how a transgenic version of Nipponbare obtained drought resistance phenotype. Using multi-omics sequencing data, we compared wild-type rice (WT) and (erf71) that obtains drought-resistance phenotype by overexpressing OsERF71, one AP2/ERF transcription factor families. A comprehensive bioinformatics analysis pipeline, including networks cascade tree, was developed for data. The results showed presence OsERF71 source network controlled global...
Adipocyte differentiation is regulated by the sequential activation of transcription factors such as CAAT/enhancer binding protein and peroxisome proliferator- activated receptor-γ (PPAR-γ). Several recent studies have shown that regulators chromatin structure are also involved in adipocyte differentiation. Here we investigated effects diallyl disulfide (DADS), an oil-soluble sulfur compound found processed garlic inhibitor histone deacetylase (HDAC), on adipogenesis. Treatment with DADS...
The measurement of skeletal muscle mass is essential for the diagnosis sarcopenia. Muscle ultrasonography has emerged as a useful tool evaluating sarcopenia because it can be used to assess quality and quantity. This study investigated whether effective estimating appendicular (ASM) screening prospectively enrolled 212 healthy volunteers aged 40–80 years. ASM was measured using bioelectrical impedance analysis. thickness (MT) echo-intensity (EI) were in four muscles (biceps brachii, BB;...
The need for developing a simple and effective assessment tool muscle mass has been increasing in rapidly aging society. This study aimed to evaluate the feasibility of surface electromyography (sEMG) parameters estimating mass. Overall, 212 healthy volunteers participated this study. Maximal voluntary contraction (MVC) strength root mean square (RMS) values motor unit potentials from electrodes on each (biceps brachii, triceps biceps femoris, rectus femoris) during isometric exercises elbow...
During the screening of herbs for inhibition melanogenesis, it was observed that ethanolic extract Angelicae Gigantis Radix (AGE) effectively inhibited isobutylmethylxanthine-induced melanogenesis in B16 melanoma cells. The melanin content significantly decreased by AGE a dose-dependent manner, and no cytotoxicity at effective concentrations. Decreased accompanied reduced enzyme activity as well expression tyrosinase protein mRNA. level tyrosinase-related 1 2 mRNAs also AGE. Additionally,...
Amyloid-β (Aβ) oligomers are implicated in Alzheimer disease (AD). However, their unstable nature and heterogeneous state disrupts elucidation of explicit role AD progression, impeding the development tools targeting soluble Aβ oligomers. Herein parallel anti-parallel variants Aβ(1-40) dimers were designed synthesized, pathogenic properties models characterized. Anti-parallel induced cognitive impairments with increased amyloidogenesis cytotoxicity, this dimer was then used a screening...