A5015481616- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Pharmacological Effects and Toxicity Studies
- Analytical Methods in Pharmaceuticals
- Drug-Induced Hepatotoxicity and Protection
- Diabetes Treatment and Management
- Pharmacology and Obesity Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Pancreatic function and diabetes
- Inflammatory mediators and NSAID effects
- Peroxisome Proliferator-Activated Receptors
- Blood Pressure and Hypertension Studies
- Atrial Fibrillation Management and Outcomes
- Occupational and environmental lung diseases
- Epilepsy research and treatment
- Plant-based Medicinal Research
- Antibiotics Pharmacokinetics and Efficacy
- Analytical Chemistry and Chromatography
- Eicosanoids and Hypertension Pharmacology
- Nitric Oxide and Endothelin Effects
- Diabetes and associated disorders
- Ion Transport and Channel Regulation
- Pharmaceutical studies and practices
- Lipoproteins and Cardiovascular Health
- Neuroendocrine Tumor Research Advances
Korea University
2015-2025
Seoul St. Mary's Hospital
1997-2023
Catholic University of Korea
1997-2023
Korea University Medical Center
2013-2022
Dongguk University Ilsan Hospital
2010-2022
University of Florida
2019
Columbus Oncology and Hematology Associates
2019
Hanyang University
2018
Samsung (South Korea)
2012-2016
Woosong University
2016
Peroxisome proliferator-activated receptor γ (PPARγ) plays a crucial role in adipocyte differentiation, glucose metabolism, and other physiological processes. To further explore the of PPARγ adipose tissues, we used Cre/loxP strategy to generate adipose-specific knockout mice. These animals exhibited marked abnormalities formation function both brown white tissues. When fed high-fat diet, mice displayed diminished weight gain despite hyperphagia, had serum concentrations leptin adiponectin,...
We evaluated the effect of CYP2C19 genotype on pharmacokinetics and pharmacodynamcis clopidogrel. Twenty-four subjects were divided into three groups basis their genotype: homozygous extensive metabolizers (homoEMs, n = 8), heterozygous EMs (heteroEMs, poor (PMs, 8). After a single 300-mg loading dose clopidogrel day 1, followed by 75-mg daily maintenance from days 2 to 7, we measured plasma levels assessed antiplatelet as pharmacodynamics. The mean area under curve (AUC) for PMs was 1.8-...
Abstract Fas ligand (FasL), perforin, TNF-α, IL-1, and NO have been considered as effector molecule(s) leading to β cell death in autoimmune diabetes. However, the real culprit(s) destruction long elusive, despite intense investigation. We others demonstrated that FasL is not a major molecule diabetes, previous inability transfer diabetes Fas-deficient nonobese diabetic (NOD)-lpr mice was due constitutive expression on lymphocytes from these mice. Here, we identified IFN-γ/TNF-α synergism...
hHR23B is the human homologue of yeast protein RAD23 and known to participate in DNA repair by stabilizing xeroderma pigmentosum group C protein. However, also have many important functions related general proteolysis. consists N-terminal ubiquitin-like (UbL), ubiquitin association 1 (UBA1), binding, UBA2 domains. The UBA domains interact with (Ub) inhibit assembly polyubiquitin. On other hand, UbL domain interacts poly-Ub binding site 2 (PUbS2) S5a protein, which can carry polyubiquitinated...
Simvastatin, a cholesterol-lowering agent, is mainly metabolized by CYP3A4/5. The objective of this study was to investigate the effect CYP3A5*3 genotype on pharmacokinetics simvastatin in humans. Twenty-two men with CYP3A5*1/*1 (n = 4), CYP3A5*1/*3 8), or CYP3A5*3/*3 10) genotypes were enrolled. Each subject ingested 20-mg dose simvastatin, and plasma concentrations measured for 12 hours after dosing. mean (+/-SD) area under concentration-time curve carriers (4.94 +/- 2.25 ng x h/mL)...
Background and objective Rifampin (INN, rifampicin) causes several drug interactions with coadministered antidiabetic drugs. Rosiglitazone is a novel thiazolidinedione drug, but little known about the interaction between rifampin rosiglitazone. Our was to investigate effect of on pharmacokinetics rosiglitazone in humans. Method In an open‐label, randomized, 2‐way crossover study, 10 healthy Korean male subjects were treated once daily for 6 days 600 mg or placebo. On day 7, single dose 8...
Dabigatran etexilate (DABE), a prodrug of dabigatran (DAB), is direct thrombin inhibitor used to prevent ischemic stroke and thromboembolism during atrial fibrillation. The effect genetic polymorphisms on its metabolism, particularly UGT2B15, has not been extensively explored in humans. This study aimed investigate the effects ABCB1, CES1 pharmacokinetics DAB acylglucuronide metabolites healthy subjects. A total 124 males were genotyped for polymorphisms. After single 150 mg dose DABE,...
Several recent in-vitro data have revealed that CYP2C19, in addition to CYP2C9, is also involved the 4-methylhydroxylation of tolbutamide. We evaluated relative contribution CYP2C9 and CYP2C19 genetic polymorphisms on disposition blood glucose lowering response tolbutamide normal healthy Korean subjects order reappraise as a selective in-vivo probe substrate activity. A single oral dose (500 mg) or placebo was administered 18 single-blind, randomized, crossover study with 2-week washout...
Carbamazepine (CBZ) is metabolized mainly by the CYP3A family of enzymes, which includes CYP3A4 and CYP3A5. Several studies have suggested that CYP3A5*3 genotype influences pharmacokinetics substrates. The present study aimed to assess effect on serum concentration CBZ at steady-state in Korean epileptic patients.The concentrations 35 patients were measured their CYP3A5 was determined. Fourteen expressors (two for CYP3A5*1/*1 12 CYP3A5*1/*3) 21 non-expressors (CYP3A5*3/*3). Dose-normalized...
CYP2C19 is a drug-metabolizing enzyme showing various genetic polymorphisms that may cause marked interindividual and interethnic variability in the disposition of its substrates. We assessed Korean population using newly developed multiplex pyrosequencing method.A method to simultaneously detect CYP2C19*2, *3, *17 alleles was designed. established frequency these 271 subjects method.The results showed 100% concordance between single methods. also validated identified by with direct...
Objective To evaluate the enantioselective disposition of lansoprazole in relation to genetic polymorphism CYP2C19. Methods A single oral dose racemic (30 mg) was administered to6 extensive metabolizers and 6 poor whose genotypes were determined by use polymerase chain reaction‐restriction fragment length polymorphism. The pharmacokineticparameters estimated from plasma concentrations racemate, its enantiomers, metabolites, which measured for 24 hours after drug administration. unbound...
Background and Objective 1,4-Dihydropyridine calcium channel blockers, including amlodipine, are mainly metabolized by cytochrome P450 (CYP) 3A. We investigated the effect of CYP3A5*3 genotype on pharmacokinetics pharmacodynamics amlodipine in healthy Korean male subjects. Methods Forty participants were enrolled genotyped for gene. Each subject ingested a 5-mg dose plasma concentrations measured 144 hours after dosing. Blood pressure pulse rate also pharmacodynamic analysis. Results Among...
Our objective was to evaluate the effect of CYP3A5 genotype on pharmacokinetics and pharmacodynamics alprazolam in healthy volunteers.Nineteen male volunteers were divided into 3 groups basis genetic polymorphism CYP3A5. The comprised subjects with CYP3A5*1/*1 (n=5), CYP3A5*1/*3 (n=7), or CYP3A5*3/*3 (n=7). After a single oral 1-mg dose alprazolam, plasma concentrations measured up 72 hours, together assessment psychomotor function by use Digit Symbol Substitution Test, according...
This study was conducted to evaluate the effects of CYP2D6 and CYP3A5 genotypes on steady-state plasma levels risperidone (RIS), 9-hydroxyrisperidone (9-OH-RIS), active moiety (RIS plus 9-OH-RIS) in Korean schizophrenic patients. Sixty-four patients were enrolled. determined, RIS 9-OH-RIS measured using high-performance liquid chromatography. The dose-normalized concentrations RIS, 9-OH-RIS, compared according genotypes. Among patients, 57 extensive metabolizers (EMs; CYP2D6*1/*1, *1/*10,...
Dose-limiting toxicities of docetaxel are widely considered to be neutropenia, anemia, skin toxicity, and nausea. One the factors that limit use is its unpredictability inter-individual variation in toxicity.In order identify genetic affect risk docetaxel-induced toxicities, we recruited patients who received chemotherapy. We genotyped 92 with single-nucleotide polymorphisms (SNPs) 5 genes: CYP3A4 (CYP3A4(*)1B, CYP3A4(*)18, CYP3A4(*)3), CYP3A5 (CYP3A5(*)2 CYP3A5(*)3), ABCB1 (C1236T,...
The stereoselective metabolism of lansoprazole enantiomers was evaluated by incubation human liver microsomes and cDNA-expressed cytochrome P450 (P450) enzymes to understand predict their disposition in humans vivo. intrinsic clearances (Cl<sub>int</sub>) the formation both hydroxy sulfone metabolites from <i>S</i>-lansoprazole were 4.9- 2.4-fold higher than those <i>R</i>-form, respectively. sums Cl<sub>int</sub> 13.5 57.3 μl/min/mg protein for <i>R</i>- <i>S</i>-lansoprazole, respectively,...