A5045848564- Gut microbiota and health
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pharmacological Effects of Natural Compounds
- Clostridium difficile and Clostridium perfringens research
- PI3K/AKT/mTOR signaling in cancer
- Immune Cell Function and Interaction
- Mycobacterium research and diagnosis
- Immune Response and Inflammation
- Autoimmune and Inflammatory Disorders Research
- Liver physiology and pathology
- NF-κB Signaling Pathways
- Helicobacter pylori-related gastroenterology studies
- Microbial Metabolites in Food Biotechnology
- Hydrogen's biological and therapeutic effects
- Ginseng Biological Effects and Applications
- Advancements in Transdermal Drug Delivery
- Glycosylation and Glycoproteins Research
- Immune cells in cancer
- Drug-Induced Hepatotoxicity and Protection
- Probiotics and Fermented Foods
- Food Quality and Safety Studies
- Inflammasome and immune disorders
- Eosinophilic Disorders and Syndromes
- Antimicrobial Peptides and Activities
- Single-cell and spatial transcriptomics
Catholic University of Korea
2020-2025
Harvard University
2020-2024
Brigham and Women's Hospital
2020-2024
Kyung Hee University
2024
Food & Nutrition
2024
Yonsei University
2021-2023
Pulmonary and Critical Care Associates
2023
Seoul National University
2011-2022
Daegu Haany University
2021-2022
Namseoul University
2020
Pro-inflammatory fibroblasts are critical for pathogenesis in rheumatoid arthritis, inflammatory bowel disease, interstitial lung and Sjögren's syndrome represent a novel therapeutic target chronic disease. However, the heterogeneity of fibroblast phenotypes, exacerbated by lack common cross-tissue taxonomy, has limited our understanding which pathways shared multiple diseases.
Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation of the joints and extra-articular manifestations. Recent studies have shown that microorganisms affect RA pathogenesis. However, few examined microbial distribution early patients, particularly female patients. In present study, we investigated gut microbiome profile functions in including preclinical clinically apparent cases. Changes microbiological diversity, composition, function each group were...
Faecalibacterium prausnitzii is a major commensal bacterium in the human gut. It produces short-chain fatty acids that promote intestinal health. However, extremely oxygen-sensitive, making it difficult to develop as probiotic. To facilitate practical application of F. prausnitzii, we investigated factors affect its growth and mammalian gut colonization. We evaluated cross-feeding interactions between seven Bifidobacterium strains, anti-inflammatory properties bacterial metabolites produced...
Macrophages regulate protective immune responses to infectious microbes, but aberrant macrophage activation frequently drives pathological inflammation. To identify regulators of vigorous activation, we analyzed RNA-seq data from synovial macrophages and identified SLAMF7 as a receptor associated with superactivated state in rheumatoid arthritis. We implicated IFN-γ key regulator expression engaging drove strong wave inflammatory cytokine expression. Induction TNF-α after engagement...
Rationale: Despite the importance of inflammation in chronic obstructive pulmonary disease (COPD), immune cell landscape lung tissue patients with mild-moderate has not been well characterized at single-cell and molecular level. Objectives: To define from COPD resolution. Methods: We performed transcriptomic, proteomic, T-cell receptor repertoire analyses on (n = 5, Global Initiative for Chronic Obstructive Lung Disease I or II), emphysema without airflow obstruction 5), end-stage 2),...
Abstract Background Rheumatoid arthritis (RA) is a systemic chronic inflammatory disease that leads to joint destruction and functional disability due the targeting of self-antigens present in synovium, cartilage, bone. RA caused by number complex factors, including genetics, environment, dietary habits, altered intestinal microbial flora. Microorganisms gut bind nod-like receptors Toll-like regulate immune system produce various metabolites, such as short-chain fatty acids (SCFAs) interact...
Lactic acid bacteria (LAB) are known to have a significant ability colonize the human intestinal tract and adhere surface of epithelial cells. Among various lactic bacteria, exopolysaccharide (EPS) producing strains provide variety health benefits for their hosts (e.g. anti-inflammatory, antioxidant, antitumor stress tolerant effects). Recently, EPSs EPS-producing cultures gained interest within food industry playing important roles as biothickeners texturizing agents due hydrocolloidal...
We examined the effect of combination therapy with metformin and tacrolimus on immune parameters including T regulatory (Treg) type 17 helper (Th17) cells in vitro vivo mice liver transplantation (LT) patients. cell proliferation subtypes after activation or allogeneic stimulation were evaluated. RNA sequencing microarray analysis used to evaluate differences gene expression. Metformin administered graft-versus-host disease (GVHD) effects assessed. Five LT patients treated changes Treg Th17...
Abstract Background Rapamycin, an inhibitor of the serine/threonine protein kinase mTOR, is immunosuppressant used to treat renal transplant recipients, but it can cause endothelial and mitochondrial dysfunction. Metformin for treatment type 2 diabetes was reported exert therapeutic effects against rheumatoid arthritis obesity by improving dysfunction via activation fibroblast growth factor 21. We investigated rapamycin–metformin combination therapy in obese mice with collagen-induced (CIA)....
The potential therapeutic effects of probiotic bacteria in rheumatoid arthritis (RA) remain controversial. Thus, this study aimed to discover based on the relationship between gut microbiome and factor (RF) RA. Bacterial genomic DNA was extracted from fecal samples 93 RA patients 16 healthy subjects. Microbiota profiling conducted through 16S rRNA sequencing bioinformatics analyses. Bifidobacterium strains human peripheral blood mononuclear cells collagen-induced (CIA) mice were assessed....
Butyl-fructooligosaccharides (B-FOSs) are newly synthesized prebiotics composed of short-chain FOS (GF2, 1-kestose; GF3, nystose; GF4, fructofuranosyl-nystose; GF5, 1-F-(1-b-D-fructofuranosyl)-2-nystose) bound with one or two butyric groups by ester bonds. Previous in vitro studies have shown that B-FOS treatment increases butyrate production and protects the growth butyrate-producing bacteria during fermentation. The aim this study was to further test as a novel prebiotic compound...
The Met receptor tyrosine kinase is an attractive target for cancer therapy as it promotes invasive tumor growth. SAIT301 a novel anti-Met antibody, which induces LRIG1-mediated degradation and inhibits However, detailed downstream mechanism by LRIG1 mediates protein down-regulation unknown. In the present study, we discovered that ubiquitination of LRIG1, in turn recruitment complex to lysosome through its interaction with Hrs, resulting concomitant both Met. We also identified USP8...
Abstract Background To evaluate the immunomodulatory effect of Lactobacillus sakei in a mouse model rheumatoid arthritis (RA) and human immune cells. Methods We evaluated whether L. reduced severity collagen-induced (CIA) modulated interleukin (IL)-17 IL-10 levels, as well it affected differentiation CD4 + T cells regulatory B osteoclastogenesis after culturing bone marrow-derived mononuclear with sakei. Results The helper 17 serum level IL-17 were suppressed by both peripheral blood...
Short-chain fatty acids (SCFAs), especially butyrate, produced in mammalian intestinal tracts via fermentation of dietary fiber, are known biofunctional compounds humans. However, the variability fermentable fiber consumed on a daily basis and diversity gut microbiota within individuals often limits production short-chain human gut. In this study, we attempted to enhance butyrate levels fecal samples by utilizing butyl-fructooligosaccharides (B-FOS) as novel prebiotic substance. Two major...
Although interstitial lung disease (ILD) causes significant morbidity and mortality in rheumatoid arthritis (RA), it is difficult to predict the development or progression of ILD, emphasising need for improved discovery through minimally invasive diagnostic tests. Aptamer-based proteomic profiling was used assess 1321 proteins from 159 patients with (RA-ILD), RA without idiopathic pulmonary fibrosis healthy controls. Differential expression gene set enrichment analyses revealed molecular...
c-Met, the high affinity receptor for hepatocyte growth factor (HGF), is one of most frequently activated tyrosine kinases in many human cancers and a target cancer therapy. However, inhibitory targeting c-Met with antibodies has proven difficult, because have intrinsic agonist activity. Therefore, strategy reducing agonism critical successful development therapies based on anti-c-Met antibodies. Here we developed mechanism-based assay method rapid screening antibodies, involving...
Patients with RA commonly use gastrointestinal (GI) protective drugs for treatment and prevention of drug-associated GI injuries. However, how these affect the gut microbiota in patients remains unknown. The objective this study was to examine according such as proton pump inhibitors (PPIs), histamine 2-receptor antagonists rebamipide.Faecal samples were obtained from 15 healthy controls 32 who receiving PPI, antagonist or rebamipide. Bacterial DNA extracted faecal 16S rRNA sequencing...
Recently, non-electrolyzed HOCl water has gained the attention of researchers as a new disinfecting agent owing to its high sterilization power, easy accessibility, and safety. Non-electrolyzed was developed through mixing at specific ratio based on hypochlorite mineral supplements, which revealed oxidizing power. In this study, we investigated effects Helicobacter pylori (H. pylori) infection in C57BL/6 mice over 10 weeks. Mice were divided into three groups: normal control (NC) group...
Fibrosis drives end-organ damage in many diseases. However, clinical trials targeting individual upstream activators of fibroblasts, such as TGFβ, have largely failed. Here, we target the leukemia inhibitory factor receptor (LIFR) a "master amplifier" multiple lung fibroblasts. In idiopathic pulmonary fibrosis (IPF), most common fibrotic disease, found that myofibroblasts had high LIF expression. Further, TGFβ1, one key drivers fibrosis, upregulated expression IPF vitro anti-LIFR antibody...
Fibrosis drives end-organ damage in many diseases. However, clinical trials targeting individual upstream activators of fibroblasts, such as TGFβ, have largely failed. Here, we target the leukemia inhibitory factor receptor (LIFR) an “autocrine master amplifier” multiple lung fibroblasts. In idiopathic pulmonary fibrosis (IPF), most common fibrotic disease, found that myofibroblasts had high LIF expression, and fibroblasts fibroblastic foci coexpressed LIFR. IPF, are “leading edge” a key...