A5033092406- Osteoarthritis Treatment and Mechanisms
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- T-cell and B-cell Immunology
- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Psoriasis: Treatment and Pathogenesis
- Inflammatory mediators and NSAID effects
- Antimicrobial Peptides and Activities
- Gut microbiota and health
- Adipokines, Inflammation, and Metabolic Diseases
- Rheumatoid Arthritis Research and Therapies
- Pharmacological Effects of Natural Compounds
- Systemic Lupus Erythematosus Research
- Coenzyme Q10 studies and effects
- Hematopoietic Stem Cell Transplantation
- Immunotherapy and Immune Responses
- Natural product bioactivities and synthesis
- Chemokine receptors and signaling
- Inflammasome and immune disorders
- Bone Metabolism and Diseases
- Cell Adhesion Molecules Research
- Atherosclerosis and Cardiovascular Diseases
- Macrophage Migration Inhibitory Factor
- Sphingolipid Metabolism and Signaling
Catholic University of Korea
2015-2024
Sogang University
2020
Seoul St. Mary's Hospital
2018
Early detection and surgical treatment are essential to achieve a good outcome in gastric cancer (GC). Stage IV recurrent GC have poor prognosis. Therefore, new treatments for needed. We investigated the intestinal microbiome of patients attempted reverse immunosuppression immune cells through modulation metabolites. evaluated levels programmed death-ligand 1 (PD-L1) interleukin (IL)-10 peripheral blood immunocytes patients. Cancer tissues were obtained from who underwent resection GC,...
Disruption of the balance among microbiota, epithelial cells, and resident immune cells in intestine is involved pathogenesis inflammatory bowel disease (IBD). Probiotics exert protective effects against IBD, probiotic commensal Lactobacillus species are common inhabitants natural especially gut. To investigate acidophilus on development L. was administered orally mice with dextran sodium sulfate (DSS)-induced colitis. DSS-induced damage therapeutic effect were investigated. Treatment...
Osteoarthritis (OA) reduces the quality of life as a result pain caused by continuous joint destruction. Inactivated Lactobacillus (LA-1) ameliorated osteoarthritis and protected cartilage modulating inflammation. In this study, we evaluated mechanism which live LA-1 OA. To investigate effect on OA progression, administered into monosodium iodoacetate (MIA)-induced animals. The threshold, damage, inflammation synovial membrane were improved LA-1. Furthermore, analysis intestinal tissues...
Abstract Background Rheumatoid arthritis (RA) is a systemic chronic inflammatory disease that leads to joint destruction and functional disability due the targeting of self-antigens present in synovium, cartilage, bone. RA caused by number complex factors, including genetics, environment, dietary habits, altered intestinal microbial flora. Microorganisms gut bind nod-like receptors Toll-like regulate immune system produce various metabolites, such as short-chain fatty acids (SCFAs) interact...
Abstract Rheumatoid arthritis (RA) is a systemic inflammatory disease that mainly affects the synovial joints. Although involvement of fibroblast growth factor (FGF) signaling pathway has been suggested as an important modulator in RA development, no clear evidence provided. In this study, we found fluid basic FGF (bFGF) concentration was significantly higher than osteoarthritis (OA) patients. bFGF stimulates proliferation and migration human fibroblast-like synoviocytes (FLSs) by activation...
Osteoarthritis (OA), which is the most common degenerative joint disorder, has been considered a non-inflammatory disease with abnormal mechanics. Interleukin (IL)-17 pleiotropic cytokine involved in inflammatory diseases and their production driven by including IL-1 IL-23. However, little known about mechanism of IL-17 development OA. Here, we investigated role pathogenesis OA using monosodium iodoacetate (MIA)-injected receptor antagonist (IL-1Ra) double-deficient mice. In MIA-injected...
Osteoarthritis (OA) is the most common form of arthritis and age-related degenerative joint disorder, which adversely affects quality life causes disability. However, pathogenesis OA remains unclear. This study was performed to examine effects Lactobacillus rhamnosus in progression. induced 6-week-old male Wistar rats by monosodium iodoacetate (MIA) injection, oral administration L. were examined this rat model. Pain severity, cartilage destruction, inflammation measured MIA-induced rats....
Local inflammation in the joint is considered to contribute osteoarthritis (OA) progression. Here, we describe an immunomodulating nanoparticle for OA treatment. Intradermal injection of lipid nanoparticles (LNPs) loaded with type II collagen (Col II) and rapamycin (LNP-Col II-R) into mice effectively induced Col II–specific anti-inflammatory regulatory T cells, substantially increased cytokine expression, reduced inflammatory immune cells proinflammatory expression joints. Consequently,...
Dysbiosis is an environmental factor that affects the induction of axial spondyloarthritis (axSpA) pathogenesis. In present study, we investigated differences in gut microbiota patients with axSpA and revealed association between specific their metabolites, SpA Using 16S rRNA sequencing data derived from feces samples 33 20 healthy controls (HCs), examined compositions microbiomes. As a result, were found to have decreased α-diversity compared HCs, indicating less diverse particular, at...
Abstract Objective To investigate the impact of STAT‐3–mediated regulation on Th17 differentiation in patients with rheumatoid arthritis (RA). Methods CD4+ T cells isolated from peripheral blood (PB) and synovial fluid (SF) were stimulated to differentiate into or Treg cells. The activity STAT‐3 was knocked down by transfecting small interfering RNA (siRNA). After 3 days culture, proportions measured flow cytometry, production interleukin‐17 (IL‐17) reverse transcriptase–polymerase chain...
To investigate the connection between p53 and interleukin-17-producing Th17 cell/Treg cell balance in rheumatoid arthritis (RA).Th17 Treg frequencies were analyzed by flow cytometry, cytokine levels supernatant determined using enzyme-linked immunosorbent assays. The expression of transcription factors was immunostaining Western blotting, interactions STAT-3 or STAT-5 immunoprecipitation-Western blot analysis. A agonist administered collagen-induced (CIA) model, effects vivo determined.CD4+...
C57BL/6 mice are known to be resistant the development of collagen-induced arthritis (CIA). However, they show a severe arthritic phenotype when Ifng gene is deleted. Although it has been proposed that IFN-γ suppresses inflammation in CIA via suppressing Th17 which involved pathogenesis CIA, exact molecular mechanism regulation by poorly understood. This study was conducted 1) clarify arthritogenic condition knockout (KO) dependent on disinhibition and 2) demonstrate IFN-γ-induced...
Aging has been reported to be associated with changes in immune function. Although frequent infection and the development of malignancy suggest decline function aging, toward proinflammatory conditions also develop at same time. Th17 cells are well known CD4(+) T cell subpopulation closely linked chronic inflammation autoimmunity. In this study, population were investigated elucidate a possible mechanism for response aging.Splenocytes isolated from 2-month-old (young) 20-month-old (aged)...
Osteoarthritis (OA) is a degenerative disease that induces pain, cartilage deformation, and joint inflammation. Mesenchymal stem cells (MSCs) are potential therapeutic agents for treatment of OA. However, MSC therapy can cause excessive Signal transducer activator transcription 3 (STAT3) modulates secretion many proinflammatory cytokines. Experimental OA was induced by intra-articular (IA) injection monosodium iodoacetate (MIA) to the right knee rats. MSCs from patients (OA-MSCs) were...
Increases in oxidative stress are thought to be associated with the development of osteoarthritis (OA). Eupatilin, one major compounds present artemisia species, was shown have both anti-oxidative and anti-inflammatory properties. Here, we investigated vivo effects eupatilin on pain severity cartilage degradation an experimental rat model OA, along mechanisms action underlying these effects. Experimental OA induced via intra-articular injection monosodium iodoacetate (MIA), oral...
Rheumatoid arthritis (RA) is a chronic and systemic inflammatory disease characterized by upregulation of cell death osteoclastogenesis. Necrostatin (NST)-1s chemical inhibitor receptor-interacting serine/threonine-protein kinase (RIPK)1, which plays role in necroptosis. We investigated whether NST-1s decreases responses mouse model collagen-induced (CIA). decreased the progression CIA synovial expression proinflammatory cytokines. Moreover, treatment necroptosis mediators such as RIPK1,...
Interleukin-1β (IL-1β) is one of the most potent pro-inflammatory cytokines implicated in a wide range autoinflammatory, autoimmune, infectious, and degenerative diseases. Therefore, many researchers have focused on developing therapeutic molecules that inhibit IL-1β-IL-1 receptor 1 (IL-1R1) interaction for treatment IL-1-related Among diseases, osteoarthritis (OA), characterized by progressive cartilage destruction, chondrocyte inflammation, extracellular matrix (ECM) degradation. Tannic...
Summary In this study, we investigated the effects of administration interleukin‐2 ( IL ‐2)/ JES 6‐1 (anti‐ ‐2 monoclonal antibody) immune complexes on expansion and activation regulatory T reg) cells, down‐regulation helper type 17 h17) control severity collagen‐induced arthritis CIA ). Wild‐type ‐induced wild‐type mice were injected intraperitoneally (i.p.) with or ‐2/ complex three times at 2‐day intervals. Treg cell surface markers analysed by flow cytometry. After injecting 6‐1, time...
Abstract PTEN is a tyrosine phosphatase with significant function in inhibiting STAT3 activation. Recently, inactivation of has been demonstrated as therapeutic candidate for autoimmune arthritis. The expression controlled by p53 regulates arthritis through modulating the balance between Th17 and Treg. We hypothesized that regulated might reduce CIA severity inflammatory response via Our results revealed could ameliorate experimental reducing activity differentiation. Systemic infusion...
Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is an important transcription that plays a pivotal role in cellular defense against oxidative injury. Nrf2 signaling involved attenuating autoimmune disorders such as rheumatoid arthritis (RA). B cells play several roles the pathogenesis of RA, autoantibody production, antigen presentation, and T-cell activation. We investigated anti-arthritic mechanisms sulforaphane, activator Nrf2, terms its effect on cells. To investigate sulforaphane...