A5001934001- Ion Channels and Receptors
- Neurobiology and Insect Physiology Research
- Ion channel regulation and function
- Osteoarthritis Treatment and Mechanisms
- Immune Cell Function and Interaction
- Muscle Physiology and Disorders
- Calcium signaling and nucleotide metabolism
- Salivary Gland Disorders and Functions
- T-cell and B-cell Immunology
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Semiconductor materials and devices
- Adipose Tissue and Metabolism
- Toxin Mechanisms and Immunotoxins
- Dermatologic Treatments and Research
- Inflammasome and immune disorders
- Immune Response and Inflammation
- Systemic Sclerosis and Related Diseases
- Advancements in Semiconductor Devices and Circuit Design
- Chemokine receptors and signaling
- Cardiac electrophysiology and arrhythmias
- Gastric Cancer Management and Outcomes
- Exercise and Physiological Responses
- Blood properties and coagulation
- SARS-CoV-2 and COVID-19 Research
University of California, Los Angeles
1996-2025
Catholic University of Korea
2010-2024
RELX Group (United States)
2024
Kyung Hee University Hospital at Gangdong
2023
University of Westminster
2022
Old Dominion University
2022
University College Dublin
2022
Kent State University
2022
University of Washington
2022
U.S. Air Force Space Command
2021
Early detection and surgical treatment are essential to achieve a good outcome in gastric cancer (GC). Stage IV recurrent GC have poor prognosis. Therefore, new treatments for needed. We investigated the intestinal microbiome of patients attempted reverse immunosuppression immune cells through modulation metabolites. evaluated levels programmed death-ligand 1 (PD-L1) interleukin (IL)-10 peripheral blood immunocytes patients. Cancer tissues were obtained from who underwent resection GC,...
Osteoarthritis (OA) reduces the quality of life as a result pain caused by continuous joint destruction. Inactivated Lactobacillus (LA-1) ameliorated osteoarthritis and protected cartilage modulating inflammation. In this study, we evaluated mechanism which live LA-1 OA. To investigate effect on OA progression, administered into monosodium iodoacetate (MIA)-induced animals. The threshold, damage, inflammation synovial membrane were improved LA-1. Furthermore, analysis intestinal tissues...
Significance Distinct membranes separate cellular organelles, and communication between organelles occurs primarily at the interorganelle membrane junctions, which are established by junctional proteins. The junctions endoplasmic reticulum (ER) plasma (PM) essential for lipid transfer Ca 2+ dynamics; however, little is known about composition of these in T cells. We identified a protein complex containing junctophilin-4 junctate as components ER–PM that regulate dynamics cells interacting...
Osteoarthritis (OA) is the most common form of arthritis and age-related degenerative joint disorder, which adversely affects quality life causes disability. However, pathogenesis OA remains unclear. This study was performed to examine effects Lactobacillus rhamnosus in progression. induced 6-week-old male Wistar rats by monosodium iodoacetate (MIA) injection, oral administration L. were examined this rat model. Pain severity, cartilage destruction, inflammation measured MIA-induced rats....
Osteoarthritis (OA) is the most common degenerative arthritis associated with pain and cartilage destruction in elderly; it known to be involved inflammation as well. A drug called celecoxib commonly used patients osteoarthritis control pain. Metformin treat type 2 diabetes but also exhibits regulation of autophagy pathway. The purpose this study investigate whether metformin can monosodium iodoacetate (MIA)-induced OA rats. was administered orally every day rats OA. Paw-withdrawal latency...
Osteoarthritis (OA) is a common degenerative joint disease characterized by breakdown of cartilage. Mitochondrial dysfunction the chondrocyte risk factor for OA progression. We examined therapeutic potential mitochondrial transplantation OA. Mitochondria were injected into knee monosodium iodoacetate-induced rats. Chondrocytes from rats or patients with cultured to examine function in cellular pathophysiology. Pain, cartilage destruction, and bone loss improved transplanted-OA The transcript...
Abstract Background Coronavirus disease 2019 (COVID-19) induces inflammation, autoantibody production, and thrombosis, which are common symptoms of autoimmune diseases, including rheumatoid arthritis (RA). However, the effect COVID-19 on is not yet fully understood. Methods This study was performed to investigate effects development progression RA using a collagen-induced (CIA) animal model. Human fibroblast-like synoviocytes (FLS) were transduced with lentivirus carrying SARS-CoV-2 spike...
Genetic and environmental factors shape an individual's susceptibility to autoimmunity. To identify genetic variations regulating effector T cell functions, we used a forward genetics screen of inbred mouse strains uncovered genomic loci linked cytokine expression. Among the candidate genes, characterized mitochondrial inner membrane protein, TMEM11, as important determinant Th1 responses. Loss TMEM11 selectively impairs reducing autoimmune symptoms in mice. Mechanistically, Tmem11-/- cells...
The expression of TRPC3 (canonical-type transient receptor potential cation channel type 3) is tightly regulated during skeletal muscle cell differentiation, and a functional interaction between RyR1 [(ryanodine 1), an SR (sarcoplasmic reticulum) Ca2+-release channel] regulates the gain Ca2+ release EC (excitation–contraction) coupling. However, it has not been possible to demonstrate direct protein–protein interactions RyR1. To identify candidate(s) for linker protein(s) in muscle, present...
Recruitment of intracellular vesicles containing the large GTPase CRACR2A to immunological synapse mediates T cell receptor signaling.
JPs (junctophilins) contribute to the formation of junctional membrane complexes in muscle cells by physically linking t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes. In humans with HCM (hypertrophic cardiomyopathy), mutations JP2 are linked altered Ca2+ signalling cardiomyocytes; however, effects these on skeletal function have not been examined. present study, we investigated role dominant-negative JP2-S165F mutation (which is associated human HCM) muscle....
Junctophilins (JPs) play an important role in the formation of junctional membrane complexes (JMC) striated muscle by physically linking transverse-tubule and sarcoplasmic reticulum (SR) membranes. Researchers have found five JP2 mutants humans with hypertrophic cardiomyopathy. Among these, Y141H S165F are associated severely altered Ca(2+) signaling cardiomyocytes. We previously reported that also induced both hypertrophy intracellular mouse skeletal myotubes. In present study, we attempted...
More than 60 Rab GTPases exist in the human genome to regulate vesicle trafficking between organelles. are members of Ras GTPase superfamily that broadly control budding, uncoating, motility and fusion vesicles most cell types. proteins interconvert active, GTP-bound form inactive, GDP-bound form. In their active conformation, they interact with various effector molecules carry out diverse functions. usually small containing only a domain C-terminal prenylation site for membrane anchoring....
Previous studies have evaluated the roles of T and B cells in pathogenesis Sjögren's syndrome (SS); however, their relationships with age-dependent metabolic abnormalities remain unclear. We examined impacts changes associated aging or on populations SS disease severity. detected increased IL-17-producing cells, which regulate inflammation, salivary glands NOD/ShiLtJ mice. Inflammation-induced human submandibular gland cell death, determined based p-MLKL RIPK3 expression levels, was...
Osteoarthritis (OA) is the most common degenerative joint disease and characterized by breakdown of cartilage. Coenzyme Q10 (CoQ10) exerts diverse biological effects on bone cartilage; observational studies have suggested that CoQ10 may slow OA progression inflammation. However, any effect remains unclear. Here, we investigated therapeutic utility CoQ10-micelles.Seven-week-old male Wistar rats were injected with monosodium iodoacetate (MIA) to induce OA. CoQ10-micelles administered orally...
Abstract Background Sjögren’s syndrome (SS) is an autoimmune disease characterized by inflammation of the exocrine gland. An imbalance gut microbiota has been linked to SS. However, molecular mechanism unclear. We investigated effects Lactobacillus acidophilus ( L . ) and propionate on development progression SS in mouse model. Methods compared microbiomes young old mice. administered up 24 weeks. The saliva flow rate histopathology salivary glands were investigated, STIM1-STING signaling...
Abstract Background Interleukin (IL)-10-producing B (B10) cells are generated in response to signals from the tumor microenvironment and promote growth by interacting with B10 cells. We investigated distributions of immune peripheral blood tissue samples patients gastric cancer (GC). Methods Patients GC who underwent radical gastrectomy Seoul St. Mary’s Hospital between August 2020 May 2021 were enrolled this study. Forty-two collected, a pair mucosal (normal cancerous mucosa; did not...
STIM1 (stromal interaction molecule 1) mediates SOCE (store-operated Ca²⁺ entry) in skeletal muscle. However, the direct role(s) of muscle, such as release from SR (sarcoplasmic reticulum) for muscle contraction, have not been identified. The times required maximal expression endogenous or Orai1, appearance puncta during differentiation mouse primary myoblasts to myotubes, were all different, and formation was detected with no stimulus differentiation, suggesting that, is a part...