A5030387724- Treatment of Major Depression
- Bipolar Disorder and Treatment
- Neurotransmitter Receptor Influence on Behavior
- Schizophrenia research and treatment
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Mental Health Treatment and Access
- Electroconvulsive Therapy Studies
- Regulation of Appetite and Obesity
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Mental Health Research Topics
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Diet and metabolism studies
- Child and Adolescent Psychosocial and Emotional Development
- Sleep and Wakefulness Research
- Restless Legs Syndrome Research
- Autism Spectrum Disorder Research
- Suicide and Self-Harm Studies
- Attention Deficit Hyperactivity Disorder
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Maternal Mental Health During Pregnancy and Postpartum
- Transcranial Magnetic Stimulation Studies
Korea University
2011-2021
Korea University Medical Center
2007-2018
The Geneva Association
2016-2017
Chinese University of Hong Kong
2016-2017
Hanyang University
2015
Seinan Gakuin University
2015
Korea University
2015
Seoul National University
2014
Doil Choi and colleagues report the genome sequence of hot pepper, Capsicum annuum, as well resequencing two cultivated peppers a wild species, chinense. Comparative genomic analysis across Solanaceae provides insights into expansion, pungency, ripening disease resistance in peppers. Hot pepper (Capsicum annuum), one oldest domesticated crops Americas, is most widely grown spice crop world. We whole-genome sequencing assembly (Mexican landrace annuum cv. CM334) at 186.6× coverage. also de...
Posttraumatic stress disorder (PTSD) is a prevalent anxiety marked by behavioral, physiologic, and hormonal alterations. The etiology of PTSD unknown, although exposure to traumatic event constitutes necessary, but not sufficient, factor. Serotonergic dysfunction has been implicated in PTSD. present study examined the possible association between serotonin-transporter-linked polymorphic region (SERTPR) genotype allele frequencies SERTPR were analyzed 100 patients 197 unrelated healthy...
Abstract A single nucleotide polymorphism of rs1360780 in the FKBP5 gene is associated with a predisposition to developing major depressive disorder (MDD). We investigated interactive effects allelic variants, DNA methylation, and diagnosis MDD on structural changes entire brain. One hundred fourteen patients eighty-eight healthy controls underwent T1-weighted magnetic resonance imaging genotyping, including methylation intron 7. analyzed volume cortical subcortical regions thickness using...
Abstract Recent studies have reported that methylation of the brain-derived neurotrophic factor ( BDNF ) gene promoter is associated with major depressive disorder (MDD). This study aimed to investigate association between cortical thickness and promoters as well serum levels in MDD. The participants consisted 65 patients recurrent MDD age- gender-matched healthy controls. Methylation were compared groups. right medial orbitofrontal, lingual, lateral occipital, left pars triangularis,...
The 5-HTR2A gene is a candidate for influencing the clinical response to antidepressant treatment. purpose of this study was determine relationship between –1438A/G polymorphism in and citalopram Korean population with major depressive disorder (MDD). Citalopram administered 4 weeks 71 patients who completed study. We found significant differences genotype, allele, carrier distribution normal group MDD (genotypes: χ<sup>2</sup> = 6.473, d.f. 2, p 0.039; alleles: 5.589, 1, 0.018;...
Purpose:The purpose of this study was to evaluate the effects age at onset first major depressive episode on clinical features individuals with disorder (MDD) in a large cohort Korean depressed patients.Materials and Methods: We recruited 419 MDD patients over 18 years from Clinical Research Center for Depression South Korea.At start study, self-reported by subjects.The subjects were divided into four age-at-onset subgroups: childhood adolescent (ages <18), early adult 18-44), middle 45-59),...
To investigate the prevalence, clinical manifestations, and correlates of insomnia in a large cohort Korean patients with depressive disorders.We recruited 944 disorders from Clinical Research Center for Depression South Korea (CRESCEND) study. Psychometric scales were used to assess depression (HAMD), anxiety (HAMA), psychotic symptoms (BPRS), global severity (CGI-S), functioning (SOFAS). Insomnia levels determined by adding scores all items on HAMD subscale. The characteristics 'low...
This study investigated the possible effect of -1438A/G single-nucleotide polymorphism in promoter region serotonin 2A receptor (5-HTR2A) gene on major depressive disorder (MDD) a Korean population. was analyzed 189 patients with MDD and 148 unrelated healthy controls using case-control design, which revealed significant difference genotype distributions (chi(2) = 10.78, d.f. 2, p 0.005). The frequency -1438G allele also much higher than normal 7.20, 0.007; OR 1.52, 95% CI 1.12-2.06). We...
Objective This study investigates the relationship between serotonin transporter linked polymorphic region (5-HTTLPR) and long-term outcome of antidepressant treatment. Methods One hundred twenty-eight patients with major depressive disorder were evaluated for (up to 3 years) The severity improvement depression assessed Clinical Global Impression scale. genotypes 5-HTTLPR in determined using polymerase chain reaction. Results During treatment antidepressants (1–3 years treatment), clinical...
Noradrenergic and serotonergic abnormalities have long been implicated in patients with major depression. The novel selective norepinephrine reuptake inhibitor reboxetine has shown to be at least as effective imipramine, desipramine fluoxetine the treatment of It is suggested that dysfunction transporter (NET) may related Although transcriptional activity NET gene expression little known, it a good candidate for Therefore, we investigated whether T-182C polymorphism associated depression...
This study was conducted to evaluate the effects of CYP2D6 and CYP3A5 genotypes on steady-state plasma levels risperidone (RIS), 9-hydroxyrisperidone (9-OH-RIS), active moiety (RIS plus 9-OH-RIS) in Korean schizophrenic patients. Sixty-four patients were enrolled. determined, RIS 9-OH-RIS measured using high-performance liquid chromatography. The dose-normalized concentrations RIS, 9-OH-RIS, compared according genotypes. Among patients, 57 extensive metabolizers (EMs; CYP2D6*1/*1, *1/*10,...